TY - JOUR
AU - Schrack, Jennifer A.
AB - Background:Gradual disengagement from daily physical activity (PA) could signal present or emerging mild cognitive impairment (MCI) or Alzheimer’s disease (AD).Objective:This study examined whether accelerometry-derived patterns of everyday movement differ by cognitive diagnosis in participants of the Baltimore Longitudinal Study of Aging (BLSA).Methods:Activity patterns, overall and by time-of-day, were cross-sectionally compared between participants with adjudicated normal cognition (n = 549) and MCI/AD diagnoses (n = 36; 5 participants [14%] living with AD) using covariate-adjusted regression models.Results:Compared to those with normal cognition, those with MCI/AD had 2.1% higher activity fragmentation (SE = 1.0%, p = 0.036) but similar mean total activity counts/day (p = 0.075) and minutes/day spent active (p = 0.174). Time-of-day analyses show MCI/AD participants had lower activity counts and minutes spent active during waking hours (6:00 am–5:59 pm; p < 0.01 for all). Also, they had lower activity fragmentation from 12:00–5:59 am (p < 0.001), but higher fragmentation from 12:00–5:59 pm (p = 0.026).Conclusion:Differences in the timing and patterns of physical activity throughout the day linked to MCI/AD diagnoses warrant further investigation into potential clinical utility.
TI - Daily Physical Activity Patterns as a Window on Cognitive Diagnosis in the Baltimore Longitudinal Study of Aging (BLSA)
JF - Journal of Alzheimer s Disease
DO - 10.3233/jad-215544
DA - 2022-07-19
UR - https://www.deepdyve.com/lp/ios-press/daily-physical-activity-patterns-as-a-window-on-cognitive-diagnosis-in-0LQG7KvrrQ
SP - 459
EP - 469
VL - 88
IS - 2
DP - DeepDyve
ER -