TY - JOUR
AU1 - Li, Yi
AU2 - Zeng, Jingjing
AU3 - Liang, Yongjin
AU4 - Zhao, Yanlong
AU5 - Zhang, Shujun
AU6 - Chen, Zhongyan
AU7 - Zhang, Jiawen
AU8 - Shen, Xingze
AU9 - Wang, Jiabin
AU1 - Zhang, Ying
AU1 - Sun, Yuxin
AB - As an antioxidant and antiozonant, N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) is predominantly used in the rubber industry to prevent degradation. However, 6PPD can be ozonated to generate a highly toxic transformation product called N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine quinone (6PPD-quinone), which is toxic to aquatic and terrestrial organisms. Thus, 6PPD and 6PPD-quinone, two emerging contaminants, have attracted extensive attention recently. This review discussed the levels and distribution of 6PPD and 6PPD-quinone in the environment and investigated their toxic effects on a series of organisms. 6PPD and 6PPD-quinone have been widely found in air, water, and dust, while data on soil, sediment, and biota are scarce. 6PPD-quinone can cause teratogenic, developmental, reproductive, neuronal, and genetic toxicity for organisms, at environmentally relevant concentrations. Future research should pay more attention to the bioaccumulation, biomagnification, transformation, and toxic mechanisms of 6PPD and 6PPD-quinone.
TI - A Review of N-(1,3-Dimethylbutyl)-N′-phenyl-p-Phenylenediamine (6PPD) and Its Derivative 6PPD-Quinone in the Environment
JF - Toxics
DO - 10.3390/toxics12060394
DA - 2024-05-28
UR - https://www.deepdyve.com/lp/multidisciplinary-digital-publishing-institute/a-review-of-n-1-3-dimethylbutyl-n-phenyl-p-phenylenediamine-6ppd-and-0Fg4EqZlLv
SP - 394
VL - 12
IS - 6
DP - DeepDyve
ER -