TY - JOUR
AU - Tanaka, Yasuharu
AB - Prion is an infectious particle composed of an abnormal isoform of the prion protein (PrPSc) and causes prion diseases such as bovine spongiform encephalopathy (BSE), Creutzfeldt-Jakob disease (CJD) and scrapie. Host cells express cellular prion protein (PrPC), which plays roles in normal functions such as anti-oxidative stress. PrPSc is derived from PrPC and produced by conformational conversion. Prion is notorious as a resistant pathogen, being difficult to inactivate with conventional sterilization procedures. Therefore, to prevent prion-caused iatrogenic diseases, the use of appropriate procedures to inactivate prions is important. For examples, alcohol treatment, autoclave (121˚C, 20 min) and γ-ray irradiation, which are used for disinfection, antisepsis or sterilization of viruses and bacteria, are not effective against prion. This is a fundamental review of prions and methods of their inactivation.
TI - Fundamentals of prions and their inactivation (Review)
JF - International Journal of Molecular Medicine
DO - 10.3892/ijmm.2011.605
DA - 2011-04-01
UR - https://www.deepdyve.com/lp/spandidos-publications/fundamentals-of-prions-and-their-inactivation-review-0DI0XBUmlA
SP - 483
EP - 489
VL - 27
IS - 4
DP - DeepDyve
ER -