TY - JOUR
AU - Wadsworth, R M
AB - 102P CALCIUM CHANNEL INHIBITORS : ACTIONS ON SUBTYPES OF THE CA ION CHANNEL IN SMOOTH MUSCLE D.W.P. Hay & R.M. Wadsworth, Department of Physiology & Pharmacology, University of Strathclyde, Glasgm G1 IXW. Calcium channel inhibitors act by occluding membrane ion channels that control entry of calcium ions into the cells of smooth muscle and the heart. They have found clinical use in the treatment of angina and cardiac dysrhythmias. Voltage dependent Ca channels are more susceptible to the Ca channel inhibitors than are receptor-operated channels (Bolton 1979). It is possible that these channels may exist in various subtypes, and we have investigated this using the rat vas deferens because this can be activated by a wide variety of different procedures. Rat isolated vasa deferentia were suspended in Krebs-Henseleit solution at 37O and contractions obtained with KC1 160mM (producing phasic and tonic components), noradrenaline 30pM (producing fast and slow responses) , single pulse nerve stimulation (producing a twitch having 2 phases) and prolonged contact with methoxamine 8.1pM or BaC12lmM (producing rhythmic contractions). All of these responses were abolished in Ca-free solution and blocked by LaC13, showing that they are dependent on Ca entering from the extracellular compartment, not on Ca 
TI - Calcium Channel Inhibitors: Actions on Subtypes of the CA ION Channel in Smooth Muscle
JO - Journal of Pharmacy and Pharmacology
DO - 10.1111/j.2042-7158.1982.tb00933.x
DA - 1982-12-01
UR - https://www.deepdyve.com/lp/oxford-university-press/calcium-channel-inhibitors-actions-on-subtypes-of-the-ca-ion-channel-0AiGY4laXQ
SP - 102P
EP - 102P
VL - 34
IS - Supplement_12
DP - DeepDyve
ER -