TY - JOUR
AU1 - Hildreth, Kerry L.
AU2 - Barry, Daniel W.
AU3 - Moreau, Kerrie L.
AU4 - Vande Griend, Joseph
AU5 - Meacham, Randall B.
AU6 - Nakamura, Tammie
AU7 - Wolfe, Pamela
AU8 - Kohrt, Wendy M.
AU9 - Ruscin, J. Mark
AU1 - Kittelson, John
AU1 - Cress, M. Elaine
AU1 - Ballard, Robert
AU1 - Schwartz, Robert S.
AB - Context:Aging in men is associated with reduced testosterone (T) levels and physiological changes leading to frailty, but the benefits of T supplementation are inconclusive.Objective:We studied the effects of T supplementation with and without progressive resistance training (PRT) on functional performance, strength, and body composition.Design, Setting, and Participants:We recruited 167 generally healthy community-dwelling older men (66 ± 5 years) with low-normal baseline total T levels (200–350 ng/dL).Intervention:Subjects were randomized to placebo or transdermal T gel [2 doses targeting either a lower (400–550 ng/dL) or higher (600–1000 ng/dL) T range] and to either PRT or no exercise for 12 months.Main Outcome Measure:The primary outcome was functional performance, whereas secondary outcomes were strength and body composition.Results:A total of 143 men completed the study. At 12 months, total T was 528 ± 287 ng/dL in subjects receiving any T and 287 ± 65 ng/dL in the placebo group. In the PRT group, function and strength were not different between T- and placebo-treated subjects, despite greater improvements in fat mass (P = .04) and fat-free mass (P = .01) with T. In the non-PRT group, T did not improve function but improved fat mass (P = .005), fat-free mass (P = .03), and upper body strength (P = .03) compared with placebo. There were fewer cardiovascular events in the T-treated groups compared with placebo.Conclusions:T supplementation was well tolerated and improved body composition but had no effect on functional performance. T supplementation improved upper body strength only in nonexercisers compared with placebo.
TI - Effects of Testosterone and Progressive Resistance Exercise in Healthy, Highly Functioning Older Men With Low-Normal Testosterone Levels
JF - Journal of Clinical Endocrinology and Metabolism
DO - 10.1210/jc.2012-3695
DA - 2013-05-01
UR - https://www.deepdyve.com/lp/oxford-university-press/effects-of-testosterone-and-progressive-resistance-exercise-in-healthy-0A3OL21Pxr
SP - 1891
EP - 1900
VL - 98
IS - 5
DP - DeepDyve
ER -