TY - JOUR
AU1 - Abdeldayem, Hesham
AU2 - Ghoneim, Enas
AU3 - Refaei, Ahmad
AU4 - Abou-Gabal, Ashraf
AB - Hepatol Int (2007) 1:444–448 DOI 10.1007/s12072-007-9018-1 OR IGINAL RESEARCH Obstructive jaundice promotes intestinal-barrier dysfunction and bacterial translocation: experimental study Hesham Abdeldayem Æ Enas Ghoneim Æ Ahmad Ahmad-El Refaei Æ Ashraf Abou-Gabal Received: 21 April 2007 / Accepted: 19 July 2007 / Published online: 20 September 2007 Asian Pacific Association for the Study of the Liver 2007 Abstract spleen. Samples for histopathological examination were Background Although clinical and experimental studies taken from the mucosa of the ileum and the colon and have demonstrated a correlation between obstructive evaluated for inflammatory and destructive changes. jaundice and the development of sepsis, the mechanism has Results There was no evidence of bacterial translocation not been fully elucidated. to MLNs, blood, spleen, or liver detected in any of the 12 Purpose The aim of this study was to investigate the sham-operated control rats. In contrast, bacterial translo- influence of biliary obstruction on bacterial translocation as cation was demonstrated in 8 of the 12 CBD-ligated rats a possible source of infection in cases of obstructive (P \ 0.01). In all eight cases in which translocation jaundice. occurred, Escherichia coli were cultured from the MLNs. Material and Methods Two groups of 12 Wistar rats were There 
TI - Obstructive jaundice promotes intestinal-barrier dysfunction and bacterial translocation: experimental study
JF - Hepatology International
DO - 10.1007/s12072-007-9018-1
DA - 2007-09-20
UR - https://www.deepdyve.com/lp/springer-journals/obstructive-jaundice-promotes-intestinal-barrier-dysfunction-and-084yYIHeyw
SP - 444
EP - 448
VL - 1
IS - 4
DP - DeepDyve
ER -