TY - JOUR
AU - Biglieri, Edward G.
AB - Abstract In recent years a syndrome has been described 1,2 in which hyponatremia and renal loss of sodium have been attributed to the overexpansion of body fluids resulting from the inappropriate secretion of antidiuretic hormone (ADH). The majority of cases occur in patients with carcinoma of the lung,3 but the syndrome is also associated with other diseases including porphyria,4 myxedema,5 and a variety of disorders of the central nervous system.6 The characteristic features of this syndrome are hyponatremia and hypotonicity of body fluids, continued renal excretion of sodium, urine osmolality greater than that appropriate for concomitant tonicity of plasma, normal renal and adrenal function, and correction of both hyponatremia and urinary sodium loss by fluid restriction.7,8 Recognition of this syndrome is rarely difficult, although patients with adrenal insufficiency may have similar clinical manifestations. While careful evaluation of adrenal function usually differentiates between these disorders, Bartter and References 1. Schwartz, W.B., et al: A Syndrome of Renal Sodium Loss and Hyponatremia Probably Resulting From Inappropriate Secretion of Antidiuretic Hormone , Amer J Med 23:529-542 ( (Oct) ) 1957.Crossref 2. Roberts, H.J.: The Syndrome of Hyponatremia and Renal Sodium Loss Probably Resulting From Inappropriate Secretion of Antidiuretic Hormone , Ann Intern Med 51:1420-1426 ( (Dec) ) 1959.Crossref 3. Bower, B.F., and Gordan, G.S.: Hormonal Effects of Nonendocrine Tumors , Ann Rev Med 16: 83-118, 1965.Crossref 4. Hellman, E.S.; Tschudy, D.P.; and Bartter, F.C.: Abnormal Electrolyte and Water Metabolism in Acute Intermittent Porphyria , Amer J Med 32: 734-746 ( (May) ) 1962.Crossref 5. Pettinger, W.A.; Talner, L.; and Ferris, T.F.: Inappropriate Secretion of Antidiuretic Hormone Due to Myxedema , New Eng J Med 272:362-364 ( (Feb 18) ) 1965.Crossref 6. Carter, N.W.; Rector, F.C., Jr.; and Seldin, D.W.: Hyponatremia in Cerebral Disease Resulting From the Inappropriate Secretion of Antidiuretic Hormone , New Eng J Med 264:67-72 ( (Jan 12) ) 1961.Crossref 7. Goldberg, M.: Hyponatremia and the Inappropriate Secretion of Antidiuretic Hormone , Amer J Med 35:293-298 ( (Sept) ) 1963.Crossref 8. Bartter, F.C., and Schwartz, W.B.: The Syndrome of Inappropriate Secretion of Antidiuretic Hormone , Amer J Med 42:790-806 ( (May) ) 1967.Crossref 9. Silber, R.H., and Porter, C.C.: The Determination of 17,21-Dihydroxy-20-ketosteroids in Urine and Plasma , J Biol Chem 210:923-937 ( (Oct) ) 1954. 10. Kliman, B., and Peterson, R.E.: Double Isotope Derivative Assay of Aldosterone in Biological Extracts , J Biol Chem 235:1639-1648 ( (June) ) 1960. 11. Kleeman, C.R.; Vorherr, H.; and Houghoughi, M.: Sensitivity to ADH of Normal and Diabetes Insipidus Rats , Endocrinology 80:1168-1169 ( (June) ) 1967.Crossref 12. Czaczkes, J.W.; Kleeman, C.R.; and Koenig, M.: Physiologic Studies of Antidiuretic Hormone by Its Direct Measurement in Human Plasma , J Clin Invest 43:1625-1640 ( (Aug) ) 1964.Crossref 13. Nabarrd, J.D.N.: Human Adrenal Cortex: Its Function Through Life , Boston: Little, Brown & Co., 1967, p 79. 14. Bartter, F.C., et al: The Regulation of Aldosterone Secretion in Man: The Role of Fluid Volume , J Clin Invest 35:1306-1315 ( (Nov) ) 1956.Crossref 15. Dingman, J.F., and Despointes, R.H.: Adrenal Steroid Inhibition of Vasopressin Release From the Neurohypophysis of Normal Subjects and Patients With Addison's Disease , J Clin Invest 39:1851-1963 ( (Dec) ) 1960.Crossref 16. Ahmed, A.B., et al: Increased Plasma Arginine Vasopressin in Clinical Adrenocortical Insufficiency and Its Inhibition by Glucosteroids , J Clin Invest 46:111-123 ( (Jan) ) 1967.Crossref 17. Kleeman, C.R.; Czaczkes, J.W.; and Cutler, R.: Mechanisms of Impaired Water Excretion in Adrenal and Pituitary Insufficiency: IV. Antidiuretic Hormone in Primary and Secondary Adrenal Insufficiency , J Clin Invest 43:1641-1648 ( (Aug) ) 1964.Crossref 18. Amatruda, T.T., Jr., et al: Carcinoma of the Lung With Inappropriate Antidiuresis , New Eng J Med 269:544-549 ( (Sept 12) ) 1963.Crossref 19. Bower, B.F.; Mason, D.M.; and Forsham, P.H.: Bronchogenic Carcinoma With Inappropriate Antidiuretic Activity in Plasma and Tumor , New Eng J Med 271:934-938 ( (Oct 29) ) 1964.Crossref 20. Barraclough, M.A.; Jones, J.J.; and Lee, J.: Production of Vasopressin by Anaplastic Oat Cell Carcinoma of the Bronchus , Clin Sci 31:135-144 ( (Aug) ) 1966. 21. Voherr, H., et al: Antidiuretic Principle in Malignant Tumor Extracts From Patients With Inappropriate ADH Syndrome , J Clin Endocr 28: 162-168 ( (Feb) ) 1968.Crossref 22. Dashe, A.M., and Henkin, R.: Water Intoxication After Hypophysectomy: An Unusual Case , Amer J Med Sci 241:752-757 ( (June) ) 1961.Crossref 23. Willis, R.A.: Pathology of Tumours , ed 2, St. Louis: C. V. Mosby Co., 1953, p 178. 24. Hill, G.J., II, and Wheeler, H.B.: Adrenal Insufficiency Due to Metastatic Carcinoma of the Lung: Case Report and Review of Addison's Disease Caused by Adrenal Metastases , Cancer 18: 1467-1473 ( (Nov) ) 1965.Crossref 25. Hagtvet, J.: Adrenocortical Insufficiency Due to Metastatic Infiltration of the Adrenal Gland , Acta Med Scand 174:1-10 ( (July) ) 1963.Crossref
TI - Adrenal Insufficiency and Inappropriate Secretion of Antidiuretic Hormone: Occurrence in a Patient With Carcinoma of the Lung
JF - Archives of Internal Medicine
DO - 10.1001/archinte.1969.00300180069013
DA - 1969-08-01
UR - https://www.deepdyve.com/lp/american-medical-association/adrenal-insufficiency-and-inappropriate-secretion-of-antidiuretic-04JUCQ7xVA
SP - 197
EP - 201
VL - 124
IS - 2
DP - DeepDyve
ER -