TY - JOUR
AU1 - Kovatchev, Boris P.
AU2 - Renard, Eric
AU3 - Cobelli, Claudio
AU4 - Zisser, Howard C.
AU5 - Keith-Hynes, Patrick
AU6 - Anderson, Stacey M.
AU7 - Brown, Sue A.
AU8 - Chernavvsky, Daniel R.
AU9 - Breton, Marc D.
AU1 - Farret, Anne
AU1 - Pelletier, Marie-Josée
AU1 - Place, Jérôme
AU1 - Bruttomesso, Daniela
AU1 - Del Favero, Simone
AU1 - Visentin, Roberto
AU1 - Filippi, Alessio
AU1 - Scotton, Rachele
AU1 - Avogaro, Angelo
AU1 - Doyle, Francis J.
AB - OBJECTIVETo evaluate the feasibility of a wearable artificial pancreas system, the Diabetes Assistant (DiAs), which uses a smart phone as a closed-loop control platform.RESEARCH DESIGN AND METHODSTwenty patients with type 1 diabetes were enrolled at the Universities of Padova, Montpellier, and Virginia and at Sansum Diabetes Research Institute. Each trial continued for 42 h. The United States studies were conducted entirely in outpatient setting (e.g., hotel or guest house); studies in Italy and France were hybrid hospital–hotel admissions. A continuous glucose monitoring/pump system (Dexcom Seven Plus/Omnipod) was placed on the subject and was connected to DiAs. The patient operated the system via the DiAs user interface in open-loop mode (first 14 h of study), switching to closed-loop for the remaining 28 h. Study personnel monitored remotely via 3G or WiFi connection to DiAs and were available on site for assistance.RESULTSThe total duration of proper system communication functioning was 807.5 h (274 h in open-loop and 533.5 h in closed-loop), which represented 97.7% of the total possible time from admission to discharge. This exceeded the predetermined primary end point of 80% system functionality.CONCLUSIONSThis study demonstrated that a contemporary smart phone is capable of running outpatient closed-loop control and introduced a prototype system (DiAs) for further investigation. Following this proof of concept, future steps should include equipping insulin pumps and sensors with wireless capabilities, as well as studies focusing on control efficacy and patient-oriented clinical outcomes.
TI - Feasibility of Outpatient Fully Integrated Closed-Loop Control
JF - Diabetes Care
DO - 10.2337/dc12-1965
DA - 2013-06-12
UR - https://www.deepdyve.com/lp/pubmed-central/feasibility-of-outpatient-fully-integrated-closed-loop-control-043seiAdLJ
SP - 1851
EP - 1858
VL - 36
IS - 7
DP - DeepDyve
ER -