TY - JOUR
AU - Voskoboinik, Ilia
AB - The review discusses the controversies in the field of cytotoxic lymphocyte secretory granule death pathways.A pore-forming protein, PRF, and serine proteases, Grz, are key effector molecules of CL. These toxins are stored within secretory granules, which exocytose their contents in response to immune synapse formation between the CL and virus-infected or transformed target cell. There, PRF and Grz synergize to induce various apoptotic death pathways and to maintain immune homeostasis. Mechanistic aspects of the synergy and apoptotic mechanisms are still not fully understood, and the current review will address some of the hotly debated controversies in the field.
TI - The battlefield of perforin/granzyme cell death pathways
JF - Journal of Leukocyte Biology
DO - 10.1189/jlb.0909608
DA - 2009-11-13
UR - https://www.deepdyve.com/lp/oxford-university-press/the-battlefield-of-perforin-granzyme-cell-death-pathways-01uZ9CvfCs
SP - 237
EP - 243
VL - 87
IS - 2
DP - DeepDyve
ER -