TY - JOUR
AU1 - Susngi, Terence
AU2 - Shah, Jimil
AU3 - Bhujade, Harish
AU4 - Jearth, Vaneet
AU5 - Singh, Anupam K.
AU6 - Mandavdhare, Harshal S.
AU7 - Sharma, Vishal
AU8 - Gupta, Rajesh
AU9 - Rana, Surinder
AU1 - Dutta, Usha
AB - BackgroundIncidence and risk factors for the development of extremity deep vein thrombosis (eDVT) in admitted patients of acute pancreatitis have been rarely explored.AimsTo identify the incidence of eDVT and to explore role of clinical scores for predicting eDVT in admitted patients of acute pancreatitis.MethodsWe prospectively enrolled admitted patients of acute pancreatitis and performed a weekly eDVT screen for the duration of their admission. Well’s score and Padua’s score were also calculated weekly. The incidence of venous thrombosis (eDVT and splanchnic thrombosis based on contrast-enhanced CT scan abdomen) was noted, and the risk factors were determined using multivariate analysis. The correlation between Well’s score, Padua’s score, and development of DVT was calculated using Pearson’s correlation.ResultsOf the 102 patients of acute pancreatitis enrolled, 73.5% of patients had necrotizing pancreatitis. Total of 46 patients (45.1%) developed thrombosis: 43 patients had splanchnic vein thrombosis; 5 patients had eDVT; and 1 patient had pulmonary embolism. Patients with eDVT had higher BISAP score (2.6 ± 0.9 vs 1.7 ± 0.8; p = 0.039), requirement of mechanical ventilation (60% vs 8.2%; p = 0.008), and mortality (60% vs 12.4%; p = 0.022). Well’s score of ≥ 2 had sensitivity and specificity of 80% and 96.9% for prediction of eDVT and it had better correlation with the development of eDVT compared to Pauda’s score.ConclusionIncidence of DVT is 5% in patients with acute pancreatitis requiring admission. It is associated with higher disease severity and mortality. The Well’s score is useful to predict the development of eDVT in routine clinical practice.
TI - Deep Venous Thrombosis in Acute Pancreatitis Is Associated with High Mortality: A Prospective Study
JF - Digestive Diseases and Sciences
DO - 10.1007/s10620-022-07617-2
DA - 2023-03-01
UR - https://www.deepdyve.com/lp/springer-journals/deep-venous-thrombosis-in-acute-pancreatitis-is-associated-with-high-01WV5CZ5iu
SP - 988
EP - 994
VL - 68
IS - 3
DP - DeepDyve
ER -