TY - JOUR
AU - Martin,, Stephen
AB - Abstract In developing vaccines to counteract viral infections, it is important to produce reagents that engender the type of immune response best suited to provide protection and avoid immunopathology. Recovery from infection is the principal role of T cell immunity, and cells that recognize virus-infected cells (cytotoxic T lymphocytes) and kill them-often before new virus is replicated — represent a crucial component of the recovery process. The cytotoxic T lymphocytes are particularly important in situations where the load of infection is high. In this review the cells and mediators, as well as the viral and host cell antigens involved in antiviral induction of cytotoxic T lymphocytes, are discussed. Particular attention is paid to the importance of the intracellular pathway of processing taken by viral antigens and the outcome in terms of the recognition of cytotoxic T lymphocytes. The new types of vaccines — especially subunits, antiidiotypes, and recombinant viral vectors — are discussed in terms of their likely effectiveness at inducing cytotoxic T lymphocytes. This content is only available as a PDF. Author notes The authors' work is supported by grants no AI14981 and EY05092 from the National Institutes of Health. The patience and competence of our superb secretaries, Marty Danilchuk and Elizabeth Goode, were most appreciated. We thank Carl Wust for many helpful suggestions. Please address requests for reprints to Dr. Barry T. Rouse, Department of Microbiology, College of Veterinary Medicine. University of Tennessee, M409 Walters Life Sciences Building, Knoxville, Tennessee 37996-0845. © 1988 by The University of Chicago
TI - Antiviral Cytotoxic T Lymphocyte Induction and Vaccination
JF - Clinical Infectious Diseases
DO - 10.1093/clinids/10.1.16
DA - 1988-01-01
UR - https://www.deepdyve.com/lp/oxford-university-press/antiviral-cytotoxic-t-lymphocyte-induction-and-vaccination-01Kpo3oD00
SP - 16
EP - 33
VL - 10
IS - 1
DP - DeepDyve
ER -