%0 Journal Article %T Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins %A Migawa, Michael, T %A Shen,, Wen %A Wan, W, Brad %A Vasquez,, Guillermo %A Oestergaard, Michael, E %A Low,, Audrey %A De Hoyos, Cheryl, L %A Gupta,, Ruchi %A Murray,, Susan %A Tanowitz,, Michael %A Bell,, Melanie %A Nichols, Joshua, G %A Gaus,, Hans %A Liang,, Xue-hai %A Swayze, Eric, E %A Crooke, Stanley, T %A Seth, Punit, P %J Nucleic Acids Research %V 47 %N 11 %@ 0305-1048 %D 2019-06-20 %I Oxford University Press %~ DeepDyve