%0 Journal Article %T High-Order Epistasis in Catalytic Power of Dihydrofolate Reductase Gives Rise to a Rugged Fitness Landscape in the Presence of Trimethoprim Selection %A Tamer, Yusuf Talha %A Gaszek, Ilona K %A Abdizadeh, Haleh %A Batur, Tugce Altinusak %A Reynolds, Kimberly A %A Atilgan, Ali Rana %A Atilgan, Canan %A Toprak, Erdal %J Molecular Biology and Evolution %V 36 %N 7 %P 1533-1550 %@ 0737-4038 %D 2019-07-01 %I Oxford University Press %~ DeepDyve