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Accumulation of Brain Hypointense Foci on Susceptibility-Weighted Imaging in Childhood Ataxia Telangiectasia

Accumulation of Brain Hypointense Foci on Susceptibility-Weighted Imaging in Childhood Ataxia... ORIGINAL RESEARCH PEDIATRICS Accumulation of Brain Hypointense Foci on Susceptibility- Weighted Imaging in Childhood Ataxia Telangiectasia R.A. Dineen, C.V. Blanchard, S. Pszczolkowski, S. Paine, M. Prasad, G. Chow, W.P. Whitehouse, and D.P. Auer ABSTRACT BACKGROUND AND PURPOSE: SWI hypointense cerebral lesions have been reported in adults with the inherited cerebellar neuro- degenerative disorder ataxia telangiectasia. This study aims to establish the prevalence, age-dependency, and spatial distribution of these lesions in children and young people with ataxia telangiectasia. MATERIALS AND METHODS: Participants with classic ataxia telangiectasia and matched controls underwent SWI acquisition at 3T at 1 or 2 time points. SWI hypointense lesions were manually labeled according to the Microbleed Anatomical Rating Scale. Differences in preva- lence of lesion number between groups with ataxia telangiectasia and without ataxia telangiectasia were tested with the Fisher exact test, and differences in age between participants with ataxia telangiectasia with and without lesions were tested using independent sam- ples Mann-Whitney U test. The relationship between age and lesion number was modeled as an exponential function. RESULTS: Analyzable SWI datasets from 17 participants with ataxia telangiectasia (with median age at first scan of 12.4 years; range, 4.6– 20.2 years; 8 [47%] were female) and 22 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

Accumulation of Brain Hypointense Foci on Susceptibility-Weighted Imaging in Childhood Ataxia Telangiectasia

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References (31)

Publisher
American Journal of Neuroradiology
Copyright
© 2021 by American Journal of Neuroradiology
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A7107
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL RESEARCH PEDIATRICS Accumulation of Brain Hypointense Foci on Susceptibility- Weighted Imaging in Childhood Ataxia Telangiectasia R.A. Dineen, C.V. Blanchard, S. Pszczolkowski, S. Paine, M. Prasad, G. Chow, W.P. Whitehouse, and D.P. Auer ABSTRACT BACKGROUND AND PURPOSE: SWI hypointense cerebral lesions have been reported in adults with the inherited cerebellar neuro- degenerative disorder ataxia telangiectasia. This study aims to establish the prevalence, age-dependency, and spatial distribution of these lesions in children and young people with ataxia telangiectasia. MATERIALS AND METHODS: Participants with classic ataxia telangiectasia and matched controls underwent SWI acquisition at 3T at 1 or 2 time points. SWI hypointense lesions were manually labeled according to the Microbleed Anatomical Rating Scale. Differences in preva- lence of lesion number between groups with ataxia telangiectasia and without ataxia telangiectasia were tested with the Fisher exact test, and differences in age between participants with ataxia telangiectasia with and without lesions were tested using independent sam- ples Mann-Whitney U test. The relationship between age and lesion number was modeled as an exponential function. RESULTS: Analyzable SWI datasets from 17 participants with ataxia telangiectasia (with median age at first scan of 12.4 years; range, 4.6– 20.2 years; 8 [47%] were female) and 22

Journal

American Journal of NeuroradiologyAmerican Journal of Neuroradiology

Published: Jun 1, 2021

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