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Unraveling Deep Gray Matter Atrophy and Iron and Myelin Changes in Multiple Sclerosis

Unraveling Deep Gray Matter Atrophy and Iron and Myelin Changes in Multiple Sclerosis ORIGINAL RESEARCH ADULT BRAIN Unraveling Deep Gray Matter Atrophy and Iron and Myelin Changes in Multiple Sclerosis G. Pontillo, M. Petracca, S. Monti, M. Quarantelli, C. Criscuolo, R. Lanzillo, E. Tedeschi, A. Elefante, V. Brescia Morra, A. Brunetti, S. Cocozza, and G. Palma ABSTRACT BACKGROUND AND PURPOSE: Modifications of magnetic susceptibility have been consistently demonstrated in the subcortical gray matter of MS patients, but some uncertainties remain concerning the underlying neurobiological processes and their clinical relevance. We applied quantitative susceptibility mapping and longitudinal relaxation rate relaxometry to clarify the relative contri- bution of atrophy and iron and myelin changes to deep gray matter damage and disability in MS. MATERIALS AND METHODS: Quantitative susceptibility mapping and longitudinal relaxation rate maps were computed for 91 patients and 55 healthy controls from MR images acquired at 3T. Applying an external model, we estimated iron and myelin con- centration maps for all subjects. Subsequently, changes of deep gray matter iron and myelin concentration (atrophy-dependent) and content (atrophy-independent) were investigated globally (bulk analysis) and regionally (voxel-based and atlas-based thalamic subnuclei analyses). The clinical impact of the observed MRI modifications was evaluated via regression models. RESULTS: We identified reduced thalamic (P, .001) and increased pallidal http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

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References (32)

Publisher
American Journal of Neuroradiology
Copyright
© 2021 by American Journal of Neuroradiology
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A7093
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL RESEARCH ADULT BRAIN Unraveling Deep Gray Matter Atrophy and Iron and Myelin Changes in Multiple Sclerosis G. Pontillo, M. Petracca, S. Monti, M. Quarantelli, C. Criscuolo, R. Lanzillo, E. Tedeschi, A. Elefante, V. Brescia Morra, A. Brunetti, S. Cocozza, and G. Palma ABSTRACT BACKGROUND AND PURPOSE: Modifications of magnetic susceptibility have been consistently demonstrated in the subcortical gray matter of MS patients, but some uncertainties remain concerning the underlying neurobiological processes and their clinical relevance. We applied quantitative susceptibility mapping and longitudinal relaxation rate relaxometry to clarify the relative contri- bution of atrophy and iron and myelin changes to deep gray matter damage and disability in MS. MATERIALS AND METHODS: Quantitative susceptibility mapping and longitudinal relaxation rate maps were computed for 91 patients and 55 healthy controls from MR images acquired at 3T. Applying an external model, we estimated iron and myelin con- centration maps for all subjects. Subsequently, changes of deep gray matter iron and myelin concentration (atrophy-dependent) and content (atrophy-independent) were investigated globally (bulk analysis) and regionally (voxel-based and atlas-based thalamic subnuclei analyses). The clinical impact of the observed MRI modifications was evaluated via regression models. RESULTS: We identified reduced thalamic (P, .001) and increased pallidal

Journal

American Journal of NeuroradiologyAmerican Journal of Neuroradiology

Published: Jul 1, 2021

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