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Cerebral Microbleeds Are Associated with Loss of White Matter Integrity

Cerebral Microbleeds Are Associated with Loss of White Matter Integrity ORIGINAL RESEARCH ADULT BRAIN Cerebral Microbleeds Are Associated with Loss of White Matter Integrity J.-Y. Liu, Y.-J. Zhou, F.-F. Zhai, F. Han, L.-X. Zhou, J. Ni, M. Yao, S. Zhang, Z. Jin, L. Cui, and Y.-C. Zhu ABSTRACT BACKGROUND AND PURPOSE: Previous studies have shown that diffusion tensor imaging suggests a diffuse loss of white matter integrity in people with white matter hyperintensities or lacunes. The purpose of this study was to investigate whether the pres- ence of cerebral microbleeds and their distribution are related to the integrity of white matter microstructures. MATERIALS AND METHODS: The study comprised 982 participants who underwent brain MR imaging to determine microbleed status. The cross-sectional relation between microbleeds and the microstructural integrity of the white matter was assessed by 2 statistical methods: a multilinear regression model based on the average DTI parameters of normal-appearing white matter and Tract-Based Spatial Statistics analysis, a tract-based voxelwise analysis. Fiber tractography was used to spatially describe the micro- structural abnormalities along WM tracts containing a cerebral microbleed. RESULTS: The presence of cerebral microbleeds was associated with lower mean fractional anisotropy and higher mean diffusivity, axial diffusivity, and radial diffusivity, and the association remained when cardiovascular risk factors http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

Cerebral Microbleeds Are Associated with Loss of White Matter Integrity

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Publisher
American Journal of Neuroradiology
Copyright
© 2020 by American Journal of Neuroradiology
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A6622
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL RESEARCH ADULT BRAIN Cerebral Microbleeds Are Associated with Loss of White Matter Integrity J.-Y. Liu, Y.-J. Zhou, F.-F. Zhai, F. Han, L.-X. Zhou, J. Ni, M. Yao, S. Zhang, Z. Jin, L. Cui, and Y.-C. Zhu ABSTRACT BACKGROUND AND PURPOSE: Previous studies have shown that diffusion tensor imaging suggests a diffuse loss of white matter integrity in people with white matter hyperintensities or lacunes. The purpose of this study was to investigate whether the pres- ence of cerebral microbleeds and their distribution are related to the integrity of white matter microstructures. MATERIALS AND METHODS: The study comprised 982 participants who underwent brain MR imaging to determine microbleed status. The cross-sectional relation between microbleeds and the microstructural integrity of the white matter was assessed by 2 statistical methods: a multilinear regression model based on the average DTI parameters of normal-appearing white matter and Tract-Based Spatial Statistics analysis, a tract-based voxelwise analysis. Fiber tractography was used to spatially describe the micro- structural abnormalities along WM tracts containing a cerebral microbleed. RESULTS: The presence of cerebral microbleeds was associated with lower mean fractional anisotropy and higher mean diffusivity, axial diffusivity, and radial diffusivity, and the association remained when cardiovascular risk factors

Journal

American Journal of Neuroradiology – American Journal of Neuroradiology

Published: Aug 1, 2020

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