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Direct In Vivo MRI Discrimination of Brain Stem Nuclei and Pathways

Direct In Vivo MRI Discrimination of Brain Stem Nuclei and Pathways ORIGINAL RESEARCH ADULT BRAIN Direct In Vivo MRI Discrimination of Brain Stem Nuclei and Pathways T.M. Shepherd, B. Ades-Aron, M. Bruno, H.M. Schambra, and M.J. Hoch ABSTRACT BACKGROUND AND PURPOSE: The brain stem is a complex configuration of small nuclei and pathways for motor, sensory, and au- tonomic control that are essential for life, yet internal brain stem anatomy is difficult to characterize in living subjects. We hypothesized that the 3D fast gray matter acquisition T1 inversion recovery sequence, which uses a short inversion time to sup- press signal from white matter, could improve contrast resolution of brain stem pathways and nuclei with 3T MR imaging. MATERIALS AND METHODS: After preliminary optimization for contrast resolution, the fast gray matter acquisition T1 inversion re- covery sequence was performed in 10 healthy subjects (5 women; mean age, 28.8 6 4.8 years) with the following parameters: TR/ TE/TI¼ 3000/2.55/410 ms, flip angle ¼ 4°, isotropic resolution ¼ 0.8 mm, with 4 averages (acquired separately and averaged outside k-space to reduce motion; total scan time¼ 58 minutes). One subject returned for an additional 5-average study that was com- bined with a previous session to create a highest quality atlas for anatomic assignments. A http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

Direct In Vivo MRI Discrimination of Brain Stem Nuclei and Pathways

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References (67)

Publisher
American Journal of Neuroradiology
Copyright
© 2020 by American Journal of Neuroradiology
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A6542
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL RESEARCH ADULT BRAIN Direct In Vivo MRI Discrimination of Brain Stem Nuclei and Pathways T.M. Shepherd, B. Ades-Aron, M. Bruno, H.M. Schambra, and M.J. Hoch ABSTRACT BACKGROUND AND PURPOSE: The brain stem is a complex configuration of small nuclei and pathways for motor, sensory, and au- tonomic control that are essential for life, yet internal brain stem anatomy is difficult to characterize in living subjects. We hypothesized that the 3D fast gray matter acquisition T1 inversion recovery sequence, which uses a short inversion time to sup- press signal from white matter, could improve contrast resolution of brain stem pathways and nuclei with 3T MR imaging. MATERIALS AND METHODS: After preliminary optimization for contrast resolution, the fast gray matter acquisition T1 inversion re- covery sequence was performed in 10 healthy subjects (5 women; mean age, 28.8 6 4.8 years) with the following parameters: TR/ TE/TI¼ 3000/2.55/410 ms, flip angle ¼ 4°, isotropic resolution ¼ 0.8 mm, with 4 averages (acquired separately and averaged outside k-space to reduce motion; total scan time¼ 58 minutes). One subject returned for an additional 5-average study that was com- bined with a previous session to create a highest quality atlas for anatomic assignments. A

Journal

American Journal of NeuroradiologyAmerican Journal of Neuroradiology

Published: May 1, 2020

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