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Reply: REPLY: parameters. Our aim was to apply DCE-MR imaging protocol and postprocessing methods, which can be readily implemented e appreciate the comments from Drs Lim and Moon on into clinical workflows. Wour article entitled, “Dynamic Contrast-Enhanced MRI We would next like to address the authors’ comments on Reveals Unique Blood-Brain Barrier Permeability Characteristics spatial resolution and section thickness and concerns regarding in the Hippocampus in the Normal Brain,” and appreciate the contamination of the hippocampal measurements by the hip- opportunity to respond. pocampal artery and choroid plexus. We acknowledge that cau- The first comment is focused on the permeability model tion must be exercised when interpreting our results, given the used in dynamic contrast-enhanced (DCE)-MR imaging post- small sample size in our study and the challenge in avoiding processing. In our study, we used a commercially available choroid plexus contamination in the ROI sampling of the hip- software, Olea Sphere (Olea Medical, La Ciotat, France), using pocampus, and we mention these important points in the limi- the extended Tofts permeability model to postprocess the tations section of our article. We would also like to emphasize acquired DCE-MR imaging data into blood-brain barrier per- that we used rigorous methods when http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

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References (6)

Publisher
American Journal of Neuroradiology
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A6361
Publisher site
See Article on Publisher Site

Abstract

REPLY: parameters. Our aim was to apply DCE-MR imaging protocol and postprocessing methods, which can be readily implemented e appreciate the comments from Drs Lim and Moon on into clinical workflows. Wour article entitled, “Dynamic Contrast-Enhanced MRI We would next like to address the authors’ comments on Reveals Unique Blood-Brain Barrier Permeability Characteristics spatial resolution and section thickness and concerns regarding in the Hippocampus in the Normal Brain,” and appreciate the contamination of the hippocampal measurements by the hip- opportunity to respond. pocampal artery and choroid plexus. We acknowledge that cau- The first comment is focused on the permeability model tion must be exercised when interpreting our results, given the used in dynamic contrast-enhanced (DCE)-MR imaging post- small sample size in our study and the challenge in avoiding processing. In our study, we used a commercially available choroid plexus contamination in the ROI sampling of the hip- software, Olea Sphere (Olea Medical, La Ciotat, France), using pocampus, and we mention these important points in the limi- the extended Tofts permeability model to postprocess the tations section of our article. We would also like to emphasize acquired DCE-MR imaging data into blood-brain barrier per- that we used rigorous methods when

Journal

American Journal of Neuroradiology – American Journal of Neuroradiology

Published: Dec 1, 2019

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