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Hypertension Is Associated with White Matter Disruption in Apparently Healthy Middle-Aged Individuals

Hypertension Is Associated with White Matter Disruption in Apparently Healthy Middle-Aged... ORIGINAL RESEARCH ADULT BRAIN Hypertension Is Associated with White Matter Disruption in Apparently Healthy Middle-Aged Individuals X Y. Hannawi, X L.R. Yanek, X B.G. Kral, X D. Vaidya, X L.C. Becker, X D.M. Becker, and X P.A. Nyquist ABSTRACT BACKGROUND AND PURPOSE: Traditional cardiovascular risk factors have been associated with white matter disease. Because hyper- tension results in vascular stiffness and impaired cerebral perfusion, we hypothesized that it would be the most relevant risk factor for microstructural white matter disruption in apparently healthy middle-aged individuals with a family history of early-onset coronary artery disease. MATERIALS AND METHODS: This was a cross-sectional analysis of participants in the Genetic Study of Atherosclerosis Risk with DTI. Regional fractional anisotropy of 181 segmented brain regions was measured using Eve WM Atlas. Risk factors were examined using univariate analysis for 48 regions representing deep WM structures. Minimal multivariable linear regression models adjusting for age, sex, and race and maximal linear regression models adjusting for cardiovascular risk factors were performed for regions meeting the Bonferroni threshold in the initial analysis. RESULTS: Included were 116 subjects (mean age, 49 11 years; 57% men) with a moderate load of cardiovascular risk factors. Subjects with hypertension had significantly http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

Hypertension Is Associated with White Matter Disruption in Apparently Healthy Middle-Aged Individuals

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Publisher
American Journal of Neuroradiology
Copyright
© 2018 by American Journal of Neuroradiology
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A5871
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL RESEARCH ADULT BRAIN Hypertension Is Associated with White Matter Disruption in Apparently Healthy Middle-Aged Individuals X Y. Hannawi, X L.R. Yanek, X B.G. Kral, X D. Vaidya, X L.C. Becker, X D.M. Becker, and X P.A. Nyquist ABSTRACT BACKGROUND AND PURPOSE: Traditional cardiovascular risk factors have been associated with white matter disease. Because hyper- tension results in vascular stiffness and impaired cerebral perfusion, we hypothesized that it would be the most relevant risk factor for microstructural white matter disruption in apparently healthy middle-aged individuals with a family history of early-onset coronary artery disease. MATERIALS AND METHODS: This was a cross-sectional analysis of participants in the Genetic Study of Atherosclerosis Risk with DTI. Regional fractional anisotropy of 181 segmented brain regions was measured using Eve WM Atlas. Risk factors were examined using univariate analysis for 48 regions representing deep WM structures. Minimal multivariable linear regression models adjusting for age, sex, and race and maximal linear regression models adjusting for cardiovascular risk factors were performed for regions meeting the Bonferroni threshold in the initial analysis. RESULTS: Included were 116 subjects (mean age, 49 11 years; 57% men) with a moderate load of cardiovascular risk factors. Subjects with hypertension had significantly

Journal

American Journal of Neuroradiology – American Journal of Neuroradiology

Published: Dec 1, 2018

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