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Comparative Study of MRI Biomarkers in the Substantia Nigra to Discriminate Idiopathic Parkinson Disease

Comparative Study of MRI Biomarkers in the Substantia Nigra to Discriminate Idiopathic Parkinson... ORIGINAL RESEARCH ADULT BRAIN Comparative Study of MRI Biomarkers in the Substantia Nigra to Discriminate Idiopathic Parkinson Disease X N.Pyatigorskaya,X B.Magnin,X M.Mongin,X L.Yahia-Cherif,X R.Valabregue,X D.Arnaldi,X C.Ewenczyk,X C.Poupon, X M.Vidailhet,andX S.Lehe´ricy ABSTRACT BACKGROUND AND PURPOSE: Several new MR imaging techniques have shown promising results in patients with Parkinson disease; however, the comparative diagnostic values of these measures at the individual level remain unclear. Our aim was to compare the diagnostic value of MR imaging biomarkers of substantia nigra damage for distinguishing patients with Parkinson disease from healthy volunteers. MATERIALS AND METHODS: Thirty-sixpatientsand20healthyvolunteerswereprospectivelyincluded.TheMRimagingprotocolat3T included3DT2-weightedandT1-weightedneuromelanin-sensitiveimages,diffusiontensorimages,andR2*mapping.T2*high-resolution images were also acquired at 7T to evaluate the dorsal nigral hyperintensity sign. Quantitative analysis was performed using ROIs in the substantianigradrawnmanuallyaroundtheareaofhighsignalintensityonneuromelanin-sensitiveimagesandT2-weightedimages.Visual analysis of the substantia nigra neuromelanin-sensitive signal intensity and the dorsolateral nigral hyperintensity on T2* images was performed. RESULTS: Therewasasignificantdecreaseintheneuromelanin-sensitivevolumeandsignalintensityinpatientswithParkinsondisease. There was also a significant decrease in fractional anisotropy and an increase in mean, axial, and radial diffusivity in the neuromelanin- sensitivesubstantianigraat3TandadecreaseinsubstantianigravolumeonT2*images.Thecombinationofsubstantianigravolume,signal intensity, and fractional anisotropy in the neuromelanin-sensitive substantia nigra allowed excellent diagnostic accuracy (0.93). Visual assessmentofbothsubstantianigradorsolateralhyperintensityandneuromelanin-sensitiveimageshadgooddiagnosticaccuracy(0.91and 0.86,respectively). CONCLUSIONS: Thecombinationofneuromelaninsignalandvolumechangeswithfractionalanisotropymeasurementsinthesubstantianigra showedexcellentdiagnosticaccuracy.Moreover,thehighdiagnosticaccuracyofvisualassessmentofsubstantianigrachangesusingdorsolateral hyperintensityanalysisorneuromelanin-sensitivesignalchangesindicatesthatthesetechniquesarepromisingforclinicalpractice. ABBREVIATIONS: AD  axial diffusivity; DNH  dorsal nigral hyperintensity; FA  fractional anisotropy; ICC  intraclass correlation coefficient; HV  healthy http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

Comparative Study of MRI Biomarkers in the Substantia Nigra to Discriminate Idiopathic Parkinson Disease

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References (36)

Publisher
American Journal of Neuroradiology
Copyright
© 2018 by American Journal of Neuroradiology
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A5702
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL RESEARCH ADULT BRAIN Comparative Study of MRI Biomarkers in the Substantia Nigra to Discriminate Idiopathic Parkinson Disease X N.Pyatigorskaya,X B.Magnin,X M.Mongin,X L.Yahia-Cherif,X R.Valabregue,X D.Arnaldi,X C.Ewenczyk,X C.Poupon, X M.Vidailhet,andX S.Lehe´ricy ABSTRACT BACKGROUND AND PURPOSE: Several new MR imaging techniques have shown promising results in patients with Parkinson disease; however, the comparative diagnostic values of these measures at the individual level remain unclear. Our aim was to compare the diagnostic value of MR imaging biomarkers of substantia nigra damage for distinguishing patients with Parkinson disease from healthy volunteers. MATERIALS AND METHODS: Thirty-sixpatientsand20healthyvolunteerswereprospectivelyincluded.TheMRimagingprotocolat3T included3DT2-weightedandT1-weightedneuromelanin-sensitiveimages,diffusiontensorimages,andR2*mapping.T2*high-resolution images were also acquired at 7T to evaluate the dorsal nigral hyperintensity sign. Quantitative analysis was performed using ROIs in the substantianigradrawnmanuallyaroundtheareaofhighsignalintensityonneuromelanin-sensitiveimagesandT2-weightedimages.Visual analysis of the substantia nigra neuromelanin-sensitive signal intensity and the dorsolateral nigral hyperintensity on T2* images was performed. RESULTS: Therewasasignificantdecreaseintheneuromelanin-sensitivevolumeandsignalintensityinpatientswithParkinsondisease. There was also a significant decrease in fractional anisotropy and an increase in mean, axial, and radial diffusivity in the neuromelanin- sensitivesubstantianigraat3TandadecreaseinsubstantianigravolumeonT2*images.Thecombinationofsubstantianigravolume,signal intensity, and fractional anisotropy in the neuromelanin-sensitive substantia nigra allowed excellent diagnostic accuracy (0.93). Visual assessmentofbothsubstantianigradorsolateralhyperintensityandneuromelanin-sensitiveimageshadgooddiagnosticaccuracy(0.91and 0.86,respectively). CONCLUSIONS: Thecombinationofneuromelaninsignalandvolumechangeswithfractionalanisotropymeasurementsinthesubstantianigra showedexcellentdiagnosticaccuracy.Moreover,thehighdiagnosticaccuracyofvisualassessmentofsubstantianigrachangesusingdorsolateral hyperintensityanalysisorneuromelanin-sensitivesignalchangesindicatesthatthesetechniquesarepromisingforclinicalpractice. ABBREVIATIONS: AD  axial diffusivity; DNH  dorsal nigral hyperintensity; FA  fractional anisotropy; ICC  intraclass correlation coefficient; HV  healthy

Journal

American Journal of Neuroradiology – American Journal of Neuroradiology

Published: Aug 1, 2018

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