Access the full text.
Sign up today, get DeepDyve free for 14 days.
H. Baradaran, V. Fodera, D. Mir, K. Kesavobhotla, Jana Ivanidze, U. Ozbek, Ajay Gupta, J. Claassen, P. Sanelli (2015)
Evaluating CT Perfusion Deficits in Global Cerebral Edema after Aneurysmal Subarachnoid HemorrhageAmerican Journal of Neuroradiology, 36
Elizabeth Nance, Kelsie Timbie, G. Miller, Ji Song, Cameron Louttit, A. Klibanov, Ting Shih, Ganesh Swaminathan, R. Tamargo, G. Woodworth, Justin Hanes, Justin Hanes, R. Price (2014)
Non-invasive delivery of stealth, brain-penetrating nanoparticles across the blood-brain barrier using MRI-guided focused ultrasound.Journal of controlled release : official journal of the Controlled Release Society, 189
O. Ozkul-Wermester, É. Guégan-Massardier, A. Triquenot, A. Borden, G. Pérot, E. Gerardin (2014)
Increased Blood-Brain Barrier Permeability on Perfusion Computed Tomography Predicts Hemorrhagic Transformation in Acute Ischemic StrokeEuropean Neurology, 72
(2014)
creased blood - brain barrier permeability on perfusion computed tomography predicts hemorrhagic transformation in acute ischemic stroke
S. Kety (1951)
The theory and applications of the exchange of inert gas at the lungs and tissues.Pharmacological reviews, 3 1
J. Claassen, S. Mayer (2002)
Global Cerebral Edema After Subarachnoid Hemorrhage: Frequency, Predictors, and Impact on OutcomeStroke: Journal of the American Heart Association, 33
W. Chai, Po-Chun Chu, Meng-Yen Tsai, Yu-Chun Lin, Jiun-Jie Wang, Kuo-Chen Wei, Y. Wai, Hao-Li Liu (2014)
Magnetic-resonance imaging for kinetic analysis of permeability changes during focused ultrasound-induced blood-brain barrier opening and brain drug delivery.Journal of controlled release : official journal of the Controlled Release Society, 192
K. Lawrence, Ting-Yim Lee (1998)
An Adiabatic Approximation to the Tissue Homogeneity Model for Water Exchange in the Brain: I. Theoretical DerivationJournal of Cerebral Blood Flow & Metabolism, 18
P. Tofts, G. Brix, D. Buckley, J. Evelhoch, E. Henderson, M. Knopp, H. Larsson, Ting-Yim Lee, N. Mayr, G. Parker, R. Port, June Taylor, R. Weisskoff (1999)
Estimating kinetic parameters from dynamic contrast‐enhanced t1‐weighted MRI of a diffusable tracer: Standardized quantities and symbolsJournal of Magnetic Resonance Imaging, 10
P. Gowland, P. Mansfield, P. Bullock, M. Stehling, B. Worthington, J. Firth (1992)
Dynamic studies of gadolinium uptake in brain tumors using inversion‐recovery echo‐planar imagingMagnetic Resonance in Medicine, 26
J. Ivanidze, K. Kesavabhotla, O. Kallas, D. Mir, H. Baradaran, A. Gupta, A. Segal, J. Claassen, P. Sanelli (2015)
Evaluating Blood-Brain Barrier Permeability in Delayed Cerebral Infarction after Aneurysmal Subarachnoid HemorrhageAmerican Journal of Neuroradiology, 36
E. Bennink, A. Riordan, A. Horsch, J. Dankbaar, B. Velthuis, H. Jong (2013)
A Fast Nonlinear Regression Method for Estimating Permeability in CT Perfusion ImagingJournal of Cerebral Blood Flow & Metabolism, 33
P. Sanelli, N. Anumula, Carl Johnson, J. Comunale, A. Tsiouris, H. Riina, Alan Segal, P. Stieg, Robert Zimmerman, Alvin Mushlin (2013)
Evaluating CT Perfusion Using Outcome Measures of Delayed Cerebral Ischemia in Aneurysmal Subarachnoid HemorrhageAmerican Journal of Neuroradiology, 34
Jason Hom, J. Dankbaar, J. Dankbaar, T. Schneider, T. Schneider, S. Cheng, J. Bredno, J. Bredno, M. Wintermark (2009)
Optimal Duration of Acquisition for Dynamic Perfusion CT Assessment of Blood-Brain Barrier Permeability Using the Patlak ModelAmerican Journal of Neuroradiology, 30
A. Germanò, D. d'Avella, C. Imperatore, G. Caruso, F. Tomasello (2000)
Time-Course of Blood-Brain Barrier Permeability Changes After Experimental Subarachnoid HaemorrhageActa Neurochirurgica, 142
P. Sanelli, Igor Ugorec, Carl Johnson, Jessica Tan, A. Segal, M. Fink, L. Heier, A. Tsiouris, J. Comunale, M. John, P. Stieg, R. Zimmerman, A. Mushlin (2011)
Using Quantitative CT Perfusion for Evaluation of Delayed Cerebral Ischemia Following Aneurysmal Subarachnoid HemorrhageAmerican Journal of Neuroradiology, 32
(2014)
Magnetic - resonance imaging for kinetic analysis of permeability changes during focused ultrasoundinduced blood - brain barrier opening and brain drug deliv
Kurt Kreiter, D. Copeland, Gary Bernardini, Joseph Bates, S. Peery, J. Claassen, Y. Du, Yaakov Stern, E. Connolly, S. Mayer (2002)
Predictors of Cognitive Dysfunction After Subarachnoid HemorrhageStroke: Journal of the American Heart Association, 33
J. Dankbaar, Jason Hom, T. Schneider, S. Cheng, B. Lau, I. Schaaf, S. Virmani, Scott Pohlman, William Dillon, M. Wintermark (2008)
Dynamic Perfusion CT Assessment of the Blood-Brain Barrier Permeability: First Pass versus Delayed AcquisitionAmerican Journal of Neuroradiology, 29
BACKGROUND AND PURPOSE: Blood-brain barrier permeability is not routinely evaluated in the clinical setting. Global cerebral edema occurs after SAH and is associated with BBB disruption. Detection of global cerebral edema using current imaging techniques is challenging. Our purpose was to apply blood-brain barrier permeability imaging in patients with global cerebral edema by using extended CT perfusion. MATERIALS AND METHODS: Patients with SAH underwent CTP in the early phase after aneurysmal rupture (days 0–3) and were classified as having global cerebral edema or nonglobal cerebral edema using established noncontrast CT criteria. CTP data were postprocessed into blood-brain barrier permeability quantitative maps of PS (permeability surface-area product), K trans (volume transfer constant from blood plasma to extravascular extracellular space), K ep (washout rate constant of the contrast agent from extravascular extracellular space to intravascular space), VE (extravascular extracellular space volume per unit of tissue volume), VP (plasmatic volume per unit of tissue volume), and F (plasma flow) by using Olea Sphere software. Mean values were compared using t tests. RESULTS: Twenty-two patients were included in the analysis. K ep (1.32 versus 1.52, P < .0001), K trans (0.15 versus 0.19, P < .0001), VP (0.51 versus 0.57, P = .0007), and F (1176 versus 1329, P = .0001) were decreased in global cerebral edema compared with nonglobal cerebral edema while VE (0.81 versus 0.39, P < .0001) was increased. CONCLUSIONS: Extended CTP was used to evaluate blood-brain barrier permeability in patients with SAH with and without global cerebral edema. K ep is an important indicator of altered blood-brain barrier permeability in patients with decreased blood flow, as K ep is flow-independent. Further study of blood-brain barrier permeability is needed to improve diagnosis and monitoring of global cerebral edema. ABBREVIATIONS: BBBP blood-brain barrier permeability EES extravascular extracellular space F plasma flow GCE global cerebral edema IVS intravascular space K ep washout rate constant of the contrast agent from EES to IVS K trans volume transfer constant from blood plasma to EES PS permeability surface-area product VE extravascular extracellular space volume per unit of tissue volume VP plasmatic volume per unit of tissue volume
American Journal of Neuroradiology – American Journal of Neuroradiology
Published: Sep 1, 2016
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.