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Qing Yang, Gerald Williams, R. Demeure, T. Mosher, Michael Smith (1998)
Removal of local field gradient artifacts in T2*‐weighted images at high fields by gradient‐echo slice excitation profile imagingMagnetic Resonance in Medicine, 39
R. Ordidge, J. Gorell, J. Deniau, R. Knight, J. Helpern (1994)
Assessment of relative brain iron concentrations using T2‐weighted and T2*‐weighted MRI at 3 TeslaMagnetic Resonance in Medicine, 32
W. Armstead, J. Kiessling, W. Kofke, M. Vavilala (2010)
Impaired cerebral blood flow autoregulation during posttraumatic arterial hypotension after fluid percussion brain injury is prevented by phenylephrine in female but exacerbated in male piglets by extracellular signal-related kinase mitogen-activated protein kinase upregulationCritical Care Medicine, 38
O. Speck, T. Ernst, L. Chang (2001)
Biexponential modeling of multigradient‐echo MRI data of the brainMagnetic Resonance in Medicine, 45
Brain Group, Alan Evans (2006)
The NIH MRI study of normal brain developmentNeuroImage, 30
S. Kety, C. Schmidt (1948)
THE NITROUS OXIDE METHOD FOR THE QUANTITATIVE DETERMINATION OF CEREBRAL BLOOD FLOW IN MAN: THEORY, PROCEDURE AND NORMAL VALUES.The Journal of clinical investigation, 27 4
Stéphane Cantin, M. Villien, M. Villien, Olivier Moreaud, I. Troprès, S. Keignart, E. Chipon, E. Chipon, J. Bas, J. Bas, J. Warnking, J. Warnking, Alexandre Krainik, Alexandre Krainik (2011)
Impaired cerebral vasoreactivity to CO2 in Alzheimer's disease using BOLD fMRINeuroImage, 58
B. Drayer (1988)
Imaging of the aging brain. Part I. Normal findings.Radiology, 166 3
F. Fazekas, K. Niederkorn, R. Schmidt, H. Offenbacher, Susanne Homer, G. Bertha, H. Lechner (1988)
White matter signal abnormalities in normal individuals: correlation with carotid ultrasonography, cerebral blood flow measurements, and cerebrovascular risk factors.Stroke, 19 10
T. Amano, J. Meyer, T. Okabe, T. Shaw, K. Mortel (1983)
Cerebral vasomotor responses during oxygen inhalation. Results in normal aging and dementia.Archives of neurology, 40 5
F. Fazekas, J. Chawluk, A. Alavi, H. Hurtig, R. Zimmerman (1987)
MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging.AJR. American journal of roentgenology, 149 2
S. Lee, S. Dinesh, J. Thomas (2008)
Hypertension-induced reversible posterior leukoencephalopathy syndrome causing obstructive hydrocephalusJournal of Clinical Neuroscience, 15
D. Moody, W. Brown, V. Challa, H. Ghazi-Birry, D. Reboussin (1997)
Cerebral Microvascular Alterations in Aging, Leukoaraiosis, and Alzheimer's Disease aAnnals of the New York Academy of Sciences, 826
M. Donahue, J. Blicher, L. Østergaard, D. Feinberg, B. MacIntosh, K. Miller, M. Günther, P. Jezzard (2009)
Cerebral Blood Flow, Blood Volume, and Oxygen Metabolism Dynamics in Human Visual and Motor Cortex as Measured by Whole-Brain Multi-Modal Magnetic Resonance ImagingJournal of Cerebral Blood Flow & Metabolism, 29
L. Parkes, W. Rashid, D. Chard, P. Tofts (2004)
Normal cerebral perfusion measurements using arterial spin labeling: Reproducibility, stability, and age and gender effectsMagnetic Resonance in Medicine, 51
P. Jakob, C. Hillenbrand, Tungte Wang, G. Schultz, D. Hahn, A. Haase (2001)
Rapid quantitative lung 1H T1 mappingJournal of Magnetic Resonance Imaging, 14
M. Falangola, M. Falangola, V. Dyakin, Sangpil Lee, Sang-Pil Lee, A. Bogart, J. Babb, K. Duff, K. Duff, K. Duff, R. Nixon, R. Nixon, J. Helpern (2007)
Quantitative MRI reveals aging‐associated T2 changes in mouse models of Alzheimer's diseaseNMR in Biomedicine, 20
M. Jenkinson, P. Bannister, M. Brady, Stephen Smith (2002)
Improved Optimization for the Robust and Accurate Linear Registration and Motion Correction of Brain ImagesNeuroImage, 17
B. Drayer (1989)
Basal ganglia: significance of signal hypointensity on T2-weighted MR images.Radiology, 173 2
D. Brooks, P. Luthert, D. Gadian, C. Marsden (1989)
Does signal-attenuation on high-field T2-weighted MRI of the brain reflect regional cerebral iron deposition? Observations on the relationship between regional cerebral water proton T2 values and iron levels.Journal of Neurology, Neurosurgery & Psychiatry, 52
Jesús Pujol, Carme Junqué, P. Vendrell, Josep Grau, Josep Martí-Vilalta, Carme Olivé, Jaume Gili (1992)
Biological significance of iron-related magnetic resonance imaging changes in the brain.Archives of neurology, 49 7
A. Martin, Karl Friston, J. Colebatch, R. Frackowiak (1991)
Decreases in Regional Cerebral Blood Flow with Normal AgingJournal of Cerebral Blood Flow & Metabolism, 11
M. Beer, D. Stäb, M. Oechsner, D. Hahn, H. Köstler, H. Hebestreit, P. Jakob (2009)
[Oxygen-enhanced functional MR lung imaging].Der Radiologe, 49 8
J. Mugler, J. Brookeman (1990)
Three‐dimensional magnetization‐prepared rapid gradient‐echo imaging (3D MP RAGE)Magnetic Resonance in Medicine, 15
R. Deichmann (2009)
Principles of MRI and Functional MRI
K. Iseki, T. Hanakawa, K. Hashikawa, H. Tomimoto, M. Nankaku, H. Yamauchi, M. Hallett, H. Fukuyama (2010)
Gait disturbance associated with white matter changes: A gait analysis and blood flow studyNeuroImage, 49
Xiaoqi Ding, T. Kucinski, O. Wittkugel, E. Goebell, U. Grzyska, M. Görg, A. Kohlschütter, H. Zeumer (2004)
Normal Brain Maturation Characterized With Age-Related T2 Relaxation Times: An Attempt to Develop a Quantitative Imaging Measure for Clinical UseInvestigative Radiology, 39
W. Luh, E. Wong, P. Bandettini, J. Hyde (1999)
QUIPSS II with thin‐slice TI1 periodic saturation: A method for improving accuracy of quantitative perfusion imaging using pulsed arterial spin labelingMagnetic Resonance in Medicine, 41
R. Edelman, H. Hatabu, E. Tadamura, Wei Li, P. Prasad (1996)
Noninvasive assessment of regional ventilation in the human lung using oxygen–enhanced magnetic resonance imagingNature Medicine, 2
S. Baudrexel, S. Volz, C. Preibisch, J. Klein, H. Steinmetz, R. Hilker, R. Deichmann (2009)
Rapid single‐scan T 2* ‐mapping using exponential excitation pulses and image‐based correction for linear background gradientsMagnetic Resonance in Medicine, 62
F. Fazekas, A. Alavi, J. Chawluk, R. Zimmerman, D. Hackney, L. Bilaniuk, M. Rosen, W. Alves, H. Hurtig, D. Jamieson, M. Kushner, M. Reivich (1989)
Comparison of CT, MR, and PET in Alzheimer's dementia and normal aging.Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 30 10
R. Immink, B. Born, G. Montfrans, R. Koopmans, J. Karemaker, J. Lieshout (2004)
Impaired Cerebral Autoregulation in Patients With Malignant HypertensionCirculation, 110
C. Losert, M. Peller, P. Schneider, M. Reiser (2002)
Oxygen‐enhanced MRI of the brainMagnetic Resonance in Medicine, 48
T. Autti, Raili Raininko, S. Vanhanen, M. Kallio, Pirkko Santavuori (1994)
MRI of the normal brain from early childhood to middle ageNeuroradiology, 36
Charles Lee, O. Lopez, J. Becker, C. Raji, W. Dai, L. Kuller, H. Gach (2009)
Imaging Cerebral Blood Flow in the Cognitively Normal Aging Brain with Arterial Spin Labeling: Implications for Imaging of Neurodegenerative DiseaseJournal of Neuroimaging, 19
B. Drayer (2005)
Imaging of the Aging Brain
H. Uematsu, Masaya Takahashi, H. Hatabu, C. Chin, S. Wehrli, F. Wehrli, T. Asakura (2007)
Changes in T1 and T2 Observed in Brain Magnetic Resonance Imaging With Delivery of High Concentrations of OxygenJournal of Computer Assisted Tomography, 31
M. Inglese, Y. Ge (2004)
Quantitative MRI: Hidden Age-Related Changes in Brain TissueTopics in Magnetic Resonance Imaging, 15
R. Deichmann, U. Nöth, N. Weiskopf (2009)
The basics of functional magnetic resonance imaging
(2008)
R Foundation for Statistical Computing
G. Bartzokis, T. Tishler, P. Lu, Lucy Oh, C. Lieu, J. Mintz, J. Cummings (2005)
Brain ferritin iron as a risk factor for age at onset in neurodegenerative diseasesAlzheimer's & Dementia, 1
M. Rivkin, D. Wolraich, H. Als, G. McAnulty, Samantha Butler, N. Conneman, C. Fischer, S. Vajapeyam, Richard Robertson, R. Mulkern (2004)
Prolonged T *2 values in newborn versus adult brain: Implications for fMRI studies of newbornsMagnetic Resonance in Medicine, 51
H. Akiyama, J. Meyer, K. Mortel, Y. Terayama, J. Thornby, S. Konno (1997)
Normal human aging: factors contributing to cerebral atrophyJournal of the Neurological Sciences, 152
K. Thulborn (2012)
My starting point: The discovery of an NMR method for measuring blood oxygenation using the transverse relaxation time of blood waterNeuroImage, 62
M. Fernández-Seara, F. Wehrli (2000)
Postprocessing technique to correct for background gradients in image‐based R*2 measurementsMagnetic Resonance in Medicine, 44
Seijiro Ogawa, T. Lee, A. Kay, D. Tank (1990)
Brain magnetic resonance imaging with contrast dependent on blood oxygenation.Proceedings of the National Academy of Sciences of the United States of America, 87 24
V. Marshall, W. Bradley, C. Marshall, T. Bhoopat, R. Rhodes (1988)
Deep white matter infarction: correlation of MR imaging and histopathologic findings.Radiology, 167 2
R. Breger, F. Yetkin, M. Fischer, R. Papke, V Haughton, A. Rimm (1991)
T1 and T2 in the cerebrum: correlation with age, gender, and demographic factors.Radiology, 181 2
G. Bateman, C. Levi, P. Schofield, Yang Wang, E. Lovett (2006)
Quantitative measurement of cerebral haemodynamics in early vascular dementia and Alzheimer’s diseaseJournal of Clinical Neuroscience, 13
R. Terry, R. DeTeresa, L. Hansen (1987)
Neocortical cell counts in normal human adult agingAnnals of Neurology, 21
K. Rodrigue, E. Haacke, N. Raz (2011)
Differential effects of age and history of hypertension on regional brain volumes and ironNeuroImage, 54
Donald Williams, J. Detre, J. Leigh, A. Koretsky (1992)
Magnetic resonance imaging of perfusion using spin inversion of arterial waterProceedings of the National Academy of Sciences of the United States of America, 89
R. Duara, R. Margolin, E. Robertson-tchabo, E. London, M. Schwartz, J. Renfrew, B. Koziarz, M. Sundaram, C. Grady, A. Moore, D. Ingvar, L. Sokoloff, H. Weingartner, R. Kessler, R. Manning, M. Channing, N. Cutler, S. Rapoport (1983)
Cerebral glucose utilization, as measured with positron emission tomography in 21 resting healthy men between the ages of 21 and 83 years.Brain : a journal of neurology, 106 (Pt 3)
H. Yamauchi, H. Fukuyama, S. Yamaguchi, T. Miyoshi, J. Kimura, J. Konishi (1991)
High-intensity area in the deep white matter indicating hemodynamic compromise in internal carotid artery occlusive disorders.Archives of neurology, 48 10
A. Johnston, L. Steiner, A. Gupta, D. Menon (2003)
Cerebral oxygen vasoreactivity and cerebral tissue oxygen reactivity.British journal of anaesthesia, 90 6
K. Meguro, J. Hatazawa, Tatsuo Yamaguchi, M. Itoh, T. Matsuzawa, S. Ono, H. Miyazawa, T. Hishinuma, K. Yanai, Y. Sekita, Kenji Yamada (1990)
Cerebral circulation and oxygen metabolism associated with subclinical periventricular hyperintensity as shown by magnetic resonance imagingAnnals of Neurology, 28
Stephen Smith, M. Jenkinson, M. Woolrich, C. Beckmann, Timothy Behrens, H. Johansen-Berg, P. Bannister, M. Luca, I. Drobnjak, D. Flitney, R. Niazy, James Saunders, J. Vickers, Yongyue Zhang, N. Stefano, J. Brady, P. Matthews (2004)
Advances in functional and structural MR image analysis and implementation as FSLNeuroImage, 23
S. Ogawa (1990)
Brain magnetic resonance imaging with contrast-dependent oxygenation, 87
P. Pantano, J. Baron, P. Lebrun-Grandié, N. Duquesnoy, M. Bousser, D. Comar (1984)
Regional Cerebral Blood Flow and Oxygen Consumption in Human AgingStroke, 15
D. Seals, K. Jablonski, A. Donato (2011)
Aging and vascular endothelial function in humans.Clinical science, 120 9
S. Siemonsen, J. Finsterbusch, J. Matschke, A. Lorenzen, X-Q Ding, J. Fiehler (2008)
Age-Dependent Normal Values of T2* and T2′ in Brain ParenchymaAmerican Journal of Neuroradiology, 29
A. Ericsson, J. Weis, A. Hemmingsson, M. Wikström, G. Sperber (1995)
Measurements of Magnetic Field Variations in the Human Brain Using a 3D‐FT Multiple Gradient Echo TechniqueMagnetic Resonance in Medicine, 33
C. Rosano, S. Sigurdsson, K. Siggeirsdottir, C. Phillips, M. Garcia, P. Jonsson, G. Eiriksdottir, A. Newman, T. Harris, M. Buchem, V. Gudnason, L. Launer (2010)
Magnetization transfer imaging, white matter hyperintensities, brain atrophy and slower gait in older men and womenNeurobiology of Aging, 31
BH Braffman, BH Braffman, R. Zimmerman, J. Trojanowski, N. Gonatas, W. Hickey, W. Schlaepfer (1988)
Brain MR: pathologic correlation with gross and histopathology. 1. Lacunar infarction and Virchow-Robin spaces.AJR. American journal of roentgenology, 151 3
B. Hallgren, P. Sourander (1958)
THE EFFECT OF AGE ON THE NON‐HAEMIN IRON IN THE HUMAN BRAINJournal of Neurochemistry, 3
D. Aquino, A. Bizzi, M. Grisoli, B. Garavaglia, M. Bruzzone, N. Nardocci, M. Savoiardo, L. Chiapparini (2009)
Age-related iron deposition in the basal ganglia: quantitative analysis in healthy subjects.Radiology, 252 1
S. Kety (1956)
Human cerebral blood flow and oxygen consumption as related to aging.Research publications - Association for Research in Nervous and Mental Disease, 35
C. Langkammer, N. Krebs, W. Goessler, E. Scheurer, F. Ebner, K. Yen, F. Fazekas, S. Ropele (2010)
Quantitative MR imaging of brain iron: a postmortem validation study.Radiology, 257 2
A. Nusbaum, Cheuk Tang, M. Buchsbaum, Tsei Wei, Scott Atlas (2001)
Regional and global changes in cerebral diffusion with normal aging.AJNR. American journal of neuroradiology, 22 1
K. Thulborn, J. Waterton, Paul Matthews, G. Radda (1982)
Oxygenation dependence of the transverse relaxation time of water protons in whole blood at high field.Biochimica et biophysica acta, 714 2
B. Benedetti, Arnaud Charil, M. Rovaris, E. Judica, P. Valsasina, M. Sormani, M. Filippi (2006)
Influence of aging on brain gray and white matter changes assessed by conventional, MT, and DT MRINeurology, 66
I. Awad, R. Spetzler, J. Hodak, C. Awad, R. Carey (1986)
Incidental subcortical lesions identified on magnetic resonance imaging in the elderly. I. Correlation with age and cerebrovascular risk factors.Stroke, 17 6
Joerg Magerkurth, S. Volz, M. Wagner, A. Jurcoane, S. Anti, A. Seiler, E. Hattingen, R. Deichmann (2011)
Quantitative T*2‐mapping based on multi‐slice multiple gradient echo flash imaging: Retrospective correction for subject motion effectsMagnetic Resonance in Medicine, 66
M. Beer, D. Stäb, M. Oechsner, D. Hahn, H. Köstler, H. Hebestreit, P. Jakob (2009)
Sauerstoffverstärkte funktionelle MR-LungenbildgebungDer Radiologe, 49
K. Leenders, D. Perani, A. Lammertsma, J. Heather, P. Buckingham, M. Healy, J. Gibbs, R. Wise, J. Hatazawa, S. Herold, R. Beaney, D. Brooks, T. Spinks, C. Rhodes, Richard Frackowiak, T. Jones (1990)
Cerebral blood flow, blood volume and oxygen utilization. Normal values and effect of age.Brain : a journal of neurology, 113 ( Pt 1)
BH Braffman, BH Braffman, R. Zimmerman, J. Trojanowski, N. Gonatas, W. Hickey, W. Schlaepfer (1988)
Brain MR: pathologic correlation with gross and histopathology. 2. Hyperintense white-matter foci in the elderly.AJR. American journal of roentgenology, 151 3
Marjolein Weerd, J. Greving, B. Hedblad, M. Lorenz, E. Mathiesen, D. O'leary, M. Rosvall, M. Sitzer, E. Buskens, M. Bots (2010)
Prevalence of Asymptomatic Carotid Artery Stenosis in the General Population: An Individual Participant Data Meta-AnalysisStroke, 41
BACKGROUND AND PURPOSE: Cerebral perfusion and O 2 metabolism are affected by physiologic age-related changes. High-resolution motion-corrected quantitative T2′-imaging and PASL were used to evaluate differences in deoxygenated hemoglobin and CBF of the gray matter between young and elderly healthy subjects. Further combined T2′-imaging and PASL were investigated breathing room air and 100% O 2 to evaluate age-related changes in cerebral autoregulation. MATERIALS AND METHODS: Twenty-two healthy volunteers 60–88 years of age were studied. Two scans of high-resolution motion-corrected T2′-imaging and PASL-MR imaging were obtained while subjects were either breathing room air or breathing 100% O 2 . Manual and automated regions of interest were placed in the cerebral GM to extract values from the corresponding maps. Results were compared with those of a group of young healthy subjects previously scanned with the identical protocol as that used in the present study. RESULTS: There was a significant decrease of cortical CBF ( P < .001) and cortical T2′ values ( P < .001) between young and elderly healthy subjects. In both groups, T2′ remained unchanged under hyperoxia compared with normoxia. Only in the younger but not in the elderly group could a significant ( P = .02) hyperoxic-induced decrease of the CBF be shown. CONCLUSIONS: T2′-mapping and PASL in the cerebral cortex of healthy subjects revealed a significant decrease of deoxygenated hemoglobin and of CBF with age. The constant deoxyHb level breathing 100% O 2 compared with normoxia in young and elderly GM suggests an age-appropriate cerebral autoregulation. At the younger age, hyperoxic-induced CBF decrease may protect the brain from hyperoxemia. ABBREVIATIONS: BOLD blood oxygen level–dependent deoxyHb deoxyhemoglobin GM gray matter GM frontoparietal frontoparietal cortex (automatic ROI) MPRAGE magnetization-prepared rapid acquisition of gradient echo OEF oxygen extraction fraction PASL pulsed arterial spin-labeling rCBF regional CBF
American Journal of Neuroradiology – American Journal of Neuroradiology
Published: Dec 1, 2012
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