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C. Wheeler-Kingshott, M. Cercignani (2009)
About “axial” and “radial” diffusivitiesMagnetic Resonance in Medicine, 61
Y. Assaf, P. Basser (2005)
Composite hindered and restricted model of diffusion (CHARMED) MR imaging of the human brainNeuroImage, 27
S. Mori, R. Itoh, Jiangyang Zhang, W. Kaufmann, Peter Zijl, M. Solaiyappan, P. Yarowsky (2001)
Diffusion tensor imaging of the developing mouse brainMagnetic Resonance in Medicine, 46
Stephen Smith (2002)
Fast robust automated brain extractionHuman Brain Mapping, 17
G. Tao, S. Datta, R. He, F. Nelson, J. Wolinsky, P. Narayana (2009)
Deep gray matter atrophy in multiple sclerosis: A tensor based morphometryJournal of the Neurological Sciences, 282
K. Hasan, C. Halphen, M. Boska, P. Narayana (2008)
Diffusion tensor metrics, T2 relaxation, and volumetry of the naturally aging human caudate nuclei in healthy young and middle‐aged adults: Possible implications for the neurobiology of human brain aging and diseaseMagnetic Resonance in Medicine, 59
Y. Ge, M. Law, R. Grossman (2005)
Applications of Diffusion Tensor MR Imaging in Multiple SclerosisAnnals of the New York Academy of Sciences, 1064
P. Mukherjee, Jeffrey Miller, J. Shimony, Joseph Philip, D. Nehra, A. Snyder, T. Conturo, J. Neil, R. McKinstry (2002)
Diffusion-tensor MR imaging of gray and white matter development during normal human brain maturation.AJNR. American journal of neuroradiology, 23 9
Federico Roncaroli (2012)
Neuropathology of multiple sclerosis
S. Mesaros, M. Rocca, M. Absinta, A. Ghezzi, N. Milani, L. Moiola, P. Veggiotti, G. Comi, M. Filippi (2008)
Evidence of thalamic gray matter loss in pediatric multiple sclerosisNeurology, 70
J. Sepulcre, J. Sastre-Garriga, M. Cercignani, G. Ingle, David Miller, A. Thompson (2006)
Regional gray matter atrophy in early primary progressive multiple sclerosis: a voxel-based morphometry study.Archives of neurology, 63 8
H. Mount (1973)
Multiple sclerosis and other demyelinating diseases.Canadian Medical Association journal, 108 11
B. Fischl, D. Salat, Evelina Busa, M. Albert, M. Dieterich, C. Haselgrove, A. Kouwe, R. Killiany, D. Kennedy, Shuna Klaveness, A. Montillo, N. Makris, B. Rosen, A. Dale (2002)
Whole Brain Segmentation Automated Labeling of Neuroanatomical Structures in the Human BrainNeuron, 33
J. Souplet (2009)
Évaluation de l'atrophie et de la charge lésionnelle sur des séquences IRM de patients atteints de sclérose en plaques
M. Rovaris, A. Gass, R. Bammer, S. Hickman, O. Ciccarelli, David Miller, M. Filippi (2005)
Diffusion MRI in multiple sclerosisNeurology, 65
D. Kidd, F. Barkhof, R. McConnell, P. Algra, I. Allen, T. Révész (1999)
Cortical lesions in multiple sclerosis.Brain : a journal of neurology, 122 ( Pt 1)
J. Dawson
XVIII.–The Histology of Disseminated SclerosisTransactions of the Royal Society of Edinburgh, 50
Derek Jones, M. Cercignani (2010)
Twenty‐five pitfalls in the analysis of diffusion MRI dataNMR in Biomedicine, 23
(1868)
Histologie de la sclérose en plaques [ in French ]
C. Pierpaoli, P. Basser (1996)
Toward a quantitative assessment of diffusion anisotropyMagnetic Resonance in Medicine, 36
Ludwin Sk (2000)
The neuropathology of multiple sclerosis.Neuroimaging Clinics of North America, 10
F. Tovar-Moll, I. Evangelou, A. Chiu, N. Richert, J. Ostuni, J. Ohayon, S. Auh, M. Ehrmantraut, S. Talagala, H. McFarland, F. Bagnato (2009)
Thalamic Involvement and Its Impact on Clinical Disability in Patients with Multiple Sclerosis: A Diffusion Tensor Imaging Study at 3TAmerican Journal of Neuroradiology, 30
In‐Jung Kim, H. Beck, P. Lein, D. Higgins (2002)
Interferon γ Induces Retrograde Dendritic Retraction and Inhibits Synapse FormationThe Journal of Neuroscience, 22
In‐Jung Kim, H. Beck, P. Lein, D. Higgins (2002)
Interferon gamma induces retrograde dendritic retraction and inhibits synapse formation.The Journal of neuroscience : the official journal of the Society for Neuroscience, 22 11
Stephen Smith, M. Jenkinson, M. Woolrich, C. Beckmann, Timothy Behrens, H. Johansen-Berg, P. Bannister, M. Luca, I. Drobnjak, D. Flitney, R. Niazy, James Saunders, J. Vickers, Yongyue Zhang, N. Stefano, J. Brady, P. Matthews (2004)
Advances in functional and structural MR image analysis and implementation as FSLNeuroImage, 23
J. Sastre-Garriga, J. Sepulcre, M. Cercignani, G. Ingle, DavidH. Miller, A. Thompson (2005)
Regional grey matter atrophy in early primary progressive multiple sclerosis: a voxel-based morphometry study
W. Mcdonald, A. Compston, G. Edan, D. Goodkin, H. Hartung, F. Lublin, H. McFarland, D. Paty, C. Polman, S. Reingold, M. Sandberg-wollheim, W. Sibley, A. Thompson, S. Noort, B. Weinshenker, J. Wolinsky (2001)
Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosisAnnals of Neurology, 50
B. Fischl, D. Salat, A. Kouwe, N. Makris, F. Ségonne, B. Quinn, A. Dale (2004)
Sequence-independent segmentation of magnetic resonance imagesNeuroImage, 23
K. Hasan, C. Halphen, A. Kamali, Flavia Nelson, J. Wolinsky, P. Narayana (2009)
Caudate nuclei volume, diffusion tensor metrics, and T2 relaxation in healthy adults and relapsing‐remitting multiple sclerosis patients: Implications for understanding gray matter degenerationJournal of Magnetic Resonance Imaging, 29
G. Francis, Alan Evans, D. Arnold (1995)
Neuroimaging in multiple sclerosis.Neurologic clinics, 13 1
David Miller, F. Barkhof, J. Frank, G. Parker, A. Thompson (2002)
Measurement of atrophy in multiple sclerosis: pathological basis, methodological aspects and clinical relevance.Brain : a journal of neurology, 125 Pt 8
Z. Khaleeli, M. Cercignani, B. Audoin, O. Ciccarelli, David Miller, A. Thompson (2007)
Localized grey matter damage in early primary progressive multiple sclerosis contributes to disabilityNeuroImage, 37
B. Audoin, G. Davies, Leonara Finisku, D. Chard, A. Thompson, David Miller (2006)
Localization of grey matter atrophy in early RRMSJournal of Neurology, 253
Josh Hasbani, M. Schlief, D. Fisher, M. Goldberg (2001)
Dendritic Spines Lost during Glutamate Receptor Activation Reemerge at Original Sites of Synaptic ContactThe Journal of Neuroscience, 21
B. Trapp, J. Wujek, Gerson Criste, Walid Jalabi, Xinghua Yin, G. Kidd, S. Stohlman, R. Ransohoff (2007)
Evidence for synaptic stripping by cortical microgliaGlia, 55
Gas Hop (Paris) 1868
Jiangyang Zhang, L. Richards, P. Yarowsky, Hao Huang, P. Zijl, S. Mori (2003)
Three-dimensional anatomical characterization of the developing mouse brain by diffusion tensor microimagingNeuroImage, 20
R. Bermel, R. Bakshi (2006)
The measurement and clinical relevance of brain atrophy in multiple sclerosisThe Lancet Neurology, 5
BACKGROUND AND PURPOSE: MS is an inflammatory demyelinating disease affecting both WM and GM. While WM lesions are easily visualized by conventional MR imaging, the detection of GM alterations remains challenging. This diffusion tensor MR imaging study aimed to detect and characterize diffuse microscopic alterations in 2 deep GM structures, the caudate nucleus and the thalamus, in patients with RR and SP MS. The relationship between diffusivity markers, and atrophy of the caudate and the thalamus, as well as brain lesion load and clinical status of the patients was also explored. MATERIALS AND METHODS: Twenty-three RR and 18 SP patients, along with 27 healthy controls, underwent MR imaging examination including anatomic and DTI acquisitions. Volumes, mean FA, and MD of the caudate and the thalamus, as well as WM lesion volumes, were assessed. RESULTS: FA was significantly ( P < .001) increased in the caudate and the thalamus of patients with MS compared with controls, and was higher in SP compared with RR patients. Increased FA was associated with volume decreases of caudate ( r = −0.712; P < .001) and thalamus ( r = −0.407; P < .01) in patients with MS. WM T2 lesion load was significantly associated with caudate ( r = 0.611; P < .001) and thalamic ( r = 0.354; P < .05) FA. Caudate FA, and, to a lesser extent, thalamic FA, were associated with functional deficits, as measured by EDSS and MSFC. CONCLUSIONS: Increased FA in the caudate and the thalamus may constitute a sensitive marker of MS pathologic processes, such as loss of dendrites and/or swelling of neuronal cell bodies. ABBREVIATIONS DD disease duration EDSS Expanded Disability Status Scale FA fractional anisotropy FMRIB Functional Magnetic Resonance Imaging of the Brain GM gray matter ICV intracranial volume MD mean diffusivity MSFC Multiple Sclerosis Functional Composite PD proton attenuation RR relapsing-remitting SP secondary-progressive T2-LL T2-lesion load
American Journal of Neuroradiology – American Journal of Neuroradiology
Published: Aug 1, 2012
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