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Correlation of MR Relative Cerebral Blood Volume Measurements with Cellular Density and Proliferation in High-Grade Gliomas: An Image-Guided Biopsy Study

Correlation of MR Relative Cerebral Blood Volume Measurements with Cellular Density and... This Article Free to Access Figures Only Full Text Full Text (PDF) All Versions of this Article: ajnr.A2312v1 32/3/501 most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Google Scholar Articles by Price, S. J. Articles by Gillard, J. H. PubMed PubMed Citation Articles by Price, S. J. Articles by Gillard, J. H. Hotlight (NEW!) What's Hotlight? American Journal of Neuroradiology 32:501-506, March 2011 © 2011 American Society of Neuroradiology BRAIN Correlation of MR Relative Cerebral Blood Volume Measurements with Cellular Density and Proliferation in High-Grade Gliomas: An Image-Guided Biopsy Study S.J. Price a ,b , H.A.L. Green b , A.F. Dean c , J. Joseph c , P.J. Hutchinson a and J.H. Gillard a ,d a From the Academic Neurosurgery Division (S.J.P., P.J.H., J.H.G.) b Wolfson Brain Imaging Centre (S.J.P., H.A.L.G.) c Department of Clinical Neurosciences; Department of Histopathology (A.F.D., J.J.) d University Department of Radiology (J.H.G.), University of Cambridge and Cambridge University Hospitals Foundation Trust, Cambridge, United Kingdom. Please address correspondence to S.J. Price, MD, Academic Neurosurgery Unit, Box 167, Addenbrooke's Hospital, Hills Rd, Cambridge CB2 0QQ, UK; e-mail: sjp58@cam.ac.uk BACKGROUND AND PURPOSE: As newer MR imaging techniques are used to assist with tumor grading, biopsy planning, and therapeutic response assessment, there is a need to relate the imaging characteristics to underlying pathologic processes. The aim of this study was to see how rCBV, a known marker of tumor vascularity, relates to cellular packing attenuation and cellular proliferation. MATERIALS AND METHODS: Nine patients with histologically proved high-grade gliomas and 1 with a supratentorial PNET requiring an image-guided biopsy were recruited. Patients underwent a DSC study. The rCBV at the intended biopsy sites was determined by using a histogram measure to derive the mean, maximum, and 75th centile and 90th centile values. This measure was correlated with histologic markers of the MIB-1 labeling index (as a marker of glioma cell proliferation) and the total number of neoplastic cells in a high-power field (cellular packing attenuation). RESULTS: There was a good correlation between rCBV and MIB-1 by using all the measures of rCBV. The mean rCBV provided the best results ( r = 0.66, P < .001). The only correlation with cellular packing attenuation was with the 90% centile (rCBV 90% , r = 0.36, P = .03). The increase in rCBV could be seen over 1 cm from the edge of enhancement in 4/10 cases, and at 2 cm in 1/10. CONCLUSIONS: rCBV correlated with cellular proliferation in high-grade gliomas but not with cellular packing attenuation. The increase in rCBV extended beyond the contrast-enhancing region in 50% of our patients. Abbreviations: CBV, cerebral blood volume • DSC, dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging • max, maximum • MIB-1, a monoclonal antibody directed against the Ki-67 antigen • NS, not significant • PET, positron-emission tomography • PNET, primitive neuroectodermal tumor • rCBV, relative CBV • rCBV 75% , 75th percentile CBV • rCBV 90% , 90th percentile rCBV • rCBV max , maximum rCBV • rCBV mean , mean rCBV • SPGR, spoiled gradient-recalled • VEGF, vascular endothelial growth factor • WHO, World Health Organization Home Subscribe Author Instructions Submit Online Search the AJNR Archives Feedback Help Copyright © 2011 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

Correlation of MR Relative Cerebral Blood Volume Measurements with Cellular Density and Proliferation in High-Grade Gliomas: An Image-Guided Biopsy Study

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Publisher
American Journal of Neuroradiology
Copyright
Copyright © 2011 by the American Society of Neuroradiology.
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A2312
Publisher site
See Article on Publisher Site

Abstract

This Article Free to Access Figures Only Full Text Full Text (PDF) All Versions of this Article: ajnr.A2312v1 32/3/501 most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Google Scholar Articles by Price, S. J. Articles by Gillard, J. H. PubMed PubMed Citation Articles by Price, S. J. Articles by Gillard, J. H. Hotlight (NEW!) What's Hotlight? American Journal of Neuroradiology 32:501-506, March 2011 © 2011 American Society of Neuroradiology BRAIN Correlation of MR Relative Cerebral Blood Volume Measurements with Cellular Density and Proliferation in High-Grade Gliomas: An Image-Guided Biopsy Study S.J. Price a ,b , H.A.L. Green b , A.F. Dean c , J. Joseph c , P.J. Hutchinson a and J.H. Gillard a ,d a From the Academic Neurosurgery Division (S.J.P., P.J.H., J.H.G.) b Wolfson Brain Imaging Centre (S.J.P., H.A.L.G.) c Department of Clinical Neurosciences; Department of Histopathology (A.F.D., J.J.) d University Department of Radiology (J.H.G.), University of Cambridge and Cambridge University Hospitals Foundation Trust, Cambridge, United Kingdom. Please address correspondence to S.J. Price, MD, Academic Neurosurgery Unit, Box 167, Addenbrooke's Hospital, Hills Rd, Cambridge CB2 0QQ, UK; e-mail: sjp58@cam.ac.uk BACKGROUND AND PURPOSE: As newer MR imaging techniques are used to assist with tumor grading, biopsy planning, and therapeutic response assessment, there is a need to relate the imaging characteristics to underlying pathologic processes. The aim of this study was to see how rCBV, a known marker of tumor vascularity, relates to cellular packing attenuation and cellular proliferation. MATERIALS AND METHODS: Nine patients with histologically proved high-grade gliomas and 1 with a supratentorial PNET requiring an image-guided biopsy were recruited. Patients underwent a DSC study. The rCBV at the intended biopsy sites was determined by using a histogram measure to derive the mean, maximum, and 75th centile and 90th centile values. This measure was correlated with histologic markers of the MIB-1 labeling index (as a marker of glioma cell proliferation) and the total number of neoplastic cells in a high-power field (cellular packing attenuation). RESULTS: There was a good correlation between rCBV and MIB-1 by using all the measures of rCBV. The mean rCBV provided the best results ( r = 0.66, P < .001). The only correlation with cellular packing attenuation was with the 90% centile (rCBV 90% , r = 0.36, P = .03). The increase in rCBV could be seen over 1 cm from the edge of enhancement in 4/10 cases, and at 2 cm in 1/10. CONCLUSIONS: rCBV correlated with cellular proliferation in high-grade gliomas but not with cellular packing attenuation. The increase in rCBV extended beyond the contrast-enhancing region in 50% of our patients. Abbreviations: CBV, cerebral blood volume • DSC, dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging • max, maximum • MIB-1, a monoclonal antibody directed against the Ki-67 antigen • NS, not significant • PET, positron-emission tomography • PNET, primitive neuroectodermal tumor • rCBV, relative CBV • rCBV 75% , 75th percentile CBV • rCBV 90% , 90th percentile rCBV • rCBV max , maximum rCBV • rCBV mean , mean rCBV • SPGR, spoiled gradient-recalled • VEGF, vascular endothelial growth factor • WHO, World Health Organization Home Subscribe Author Instructions Submit Online Search the AJNR Archives Feedback Help Copyright © 2011 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X

Journal

American Journal of Neuroradiology – American Journal of Neuroradiology

Published: Mar 1, 2011

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