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Primary Intracranial Choriocarcinoma: MR Imaging Findings

Primary Intracranial Choriocarcinoma: MR Imaging Findings SUMMARY: PICCC is the rarest, most malignant primary intracranial GCT. The purpose of this study was to describe and characterize the MR imaging findings in a series of 7 patients (6 males and 1 female; mean age, 11.9 years) with pathologically proved PICCC in our institution from 2004 to 2009. All tumors were located within the pineal ( n = 6) or suprasellar ( n = 1) regions. On T2-weighted MR imaging, the lesions appeared markedly heterogeneous with areas of both hypointensity and hyperintensity reflecting the histologic heterogeneity, including hemorrhage, fibrosis, cysts, or necrosis. Heterogeneous ( n = 7), ringlike ( n = 4), and/or intratumoral nodular ( n = 3) enhancement was noted on T1-weighted images with gadolinium. These MR imaging findings, combined with patient age and serum β-HCG levels, may prove helpful in distinguishing PICCC from the more common primary brain tumors, thereby avoiding biopsy of this highly vascular tumor. Abbreviations GCT germ cell tumor HCG/β-HCG human chorionic gonadotropin/β-human chorionic gonadotropin PICCC primary intracranial choriocarcinoma http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

Primary Intracranial Choriocarcinoma: MR Imaging Findings

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References (29)

Publisher
American Journal of Neuroradiology
Copyright
Copyright © 2010 by the American Society of Neuroradiology.
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A2194
pmid
20616180
Publisher site
See Article on Publisher Site

Abstract

SUMMARY: PICCC is the rarest, most malignant primary intracranial GCT. The purpose of this study was to describe and characterize the MR imaging findings in a series of 7 patients (6 males and 1 female; mean age, 11.9 years) with pathologically proved PICCC in our institution from 2004 to 2009. All tumors were located within the pineal ( n = 6) or suprasellar ( n = 1) regions. On T2-weighted MR imaging, the lesions appeared markedly heterogeneous with areas of both hypointensity and hyperintensity reflecting the histologic heterogeneity, including hemorrhage, fibrosis, cysts, or necrosis. Heterogeneous ( n = 7), ringlike ( n = 4), and/or intratumoral nodular ( n = 3) enhancement was noted on T1-weighted images with gadolinium. These MR imaging findings, combined with patient age and serum β-HCG levels, may prove helpful in distinguishing PICCC from the more common primary brain tumors, thereby avoiding biopsy of this highly vascular tumor. Abbreviations GCT germ cell tumor HCG/β-HCG human chorionic gonadotropin/β-human chorionic gonadotropin PICCC primary intracranial choriocarcinoma

Journal

American Journal of Neuroradiology – American Journal of Neuroradiology

Published: Nov 1, 2010

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