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Corroboration of Normal and Abnormal Fetal Cerebral Lamination on Postmortem MR Imaging with Postmortem Examination

Corroboration of Normal and Abnormal Fetal Cerebral Lamination on Postmortem MR Imaging with... This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: ajnr.A2193v1 31/10/1987 most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Google Scholar Articles by Widjaja, E. Articles by Shannon, P. PubMed PubMed Citation Articles by Widjaja, E. Articles by Shannon, P. Hotlight (NEW!) What's Hotlight? American Journal of Neuroradiology 31:1987-1993, November-December 2010 © 2010 American Society of Neuroradiology PEDIATRICS Corroboration of Normal and Abnormal Fetal Cerebral Lamination on Postmortem MR Imaging with Postmortem Examination E. Widjaja a , S. Geibprasert a , S. Zarei Mahmoodabadi a , N.E. Brown a and P. Shannon b a From the Department of Diagnostic Imaging (E.W., S.G., S.Z.M., N.E.B.), Hospital for Sick Children, Toronto, Ontario, Canada b Department of Pathology (P.S.), Mount Sinai Hospital, Toronto, Ontario, Canada Please address correspondence to Elysa Widjaja, MD, Department of Diagnostic Imaging, Hospital for Sick Children, 555 University Ave, Toronto, Ontario M5G 1X8, Canada; e-mail: Elysa.Widjaja@sickkids.ca BACKGROUND AND PURPOSE: The presence of normal fetal cerebral lamination of the germinal matrix, intermediate zone, subplate layer, and cortex can be used as a marker of normal fetal cerebral development. Our aim was to compare postmortem MR imaging assessment of normal and abnormal fetal cerebral lamination on T1- and T2-weighted images with histopathology. MATERIALS AND METHODS: Fifty-five formalin-fixed brains from postmortem fetuses, ranging from 16 to 30 weeks' gestational age, mean of 23 weeks, underwent T1- and T2- weighted MR imaging and subsequent sectioning and histologic examination. The cerebral lamination was graded as normal or abnormal on T1- and T2-weighted imaging and compared with postmortem findings. The sensitivity, specificity, and positive and negative predictive values of T1 and T2 assessment of cerebral lamination were calculated. RESULTS: Twenty-six fetuses had abnormal and 29 had normal cerebral lamination on histology. On T1, the overall sensitivity, specificity, and positive and negative predictive values of evaluating cerebral lamination were 96.15%(CI, 78.42%–99.80%), 89.66%(CI, 71.50%–97.29%), 89.29%(CI, 70.63%–97.19%), and 96.29%(CI, 79.11%–99.80%), respectively. On T2, the overall sensitivity, specificity, and positive and negative predictive values of evaluating cerebral lamination were 73.08%(CI, 51.95%–87.65%), 96.55%(CI, 80.37%–99.82%), 95.00%(CI, 73.06%–99.74%), and 80.00%(CI, 62.54%–90.94%), respectively. CONCLUSIONS: Postmortem MR imaging has high sensitivity, specificity, and positive and negative predictive values in assessing fetal cerebral lamination compared with histology. T1-weighted imaging has a higher sensitivity and negative predictive value, while T2-weighted imaging has a higher specificity and positive predictive value. Abbreviations: C, cortex • CI, confidence interval • G, germinal matrix • I, intermediate zone • MRI, MR imaging • NPV, negative predictive value • PPV, positive predictive value • S, subplate layer Home Subscribe Author Instructions Submit Online Search the AJNR Archives Feedback Help Copyright © 2010 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

Corroboration of Normal and Abnormal Fetal Cerebral Lamination on Postmortem MR Imaging with Postmortem Examination

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Publisher
American Journal of Neuroradiology
Copyright
Copyright © 2010 by the American Society of Neuroradiology.
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A2193
Publisher site
See Article on Publisher Site

Abstract

This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: ajnr.A2193v1 31/10/1987 most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Google Scholar Articles by Widjaja, E. Articles by Shannon, P. PubMed PubMed Citation Articles by Widjaja, E. Articles by Shannon, P. Hotlight (NEW!) What's Hotlight? American Journal of Neuroradiology 31:1987-1993, November-December 2010 © 2010 American Society of Neuroradiology PEDIATRICS Corroboration of Normal and Abnormal Fetal Cerebral Lamination on Postmortem MR Imaging with Postmortem Examination E. Widjaja a , S. Geibprasert a , S. Zarei Mahmoodabadi a , N.E. Brown a and P. Shannon b a From the Department of Diagnostic Imaging (E.W., S.G., S.Z.M., N.E.B.), Hospital for Sick Children, Toronto, Ontario, Canada b Department of Pathology (P.S.), Mount Sinai Hospital, Toronto, Ontario, Canada Please address correspondence to Elysa Widjaja, MD, Department of Diagnostic Imaging, Hospital for Sick Children, 555 University Ave, Toronto, Ontario M5G 1X8, Canada; e-mail: Elysa.Widjaja@sickkids.ca BACKGROUND AND PURPOSE: The presence of normal fetal cerebral lamination of the germinal matrix, intermediate zone, subplate layer, and cortex can be used as a marker of normal fetal cerebral development. Our aim was to compare postmortem MR imaging assessment of normal and abnormal fetal cerebral lamination on T1- and T2-weighted images with histopathology. MATERIALS AND METHODS: Fifty-five formalin-fixed brains from postmortem fetuses, ranging from 16 to 30 weeks' gestational age, mean of 23 weeks, underwent T1- and T2- weighted MR imaging and subsequent sectioning and histologic examination. The cerebral lamination was graded as normal or abnormal on T1- and T2-weighted imaging and compared with postmortem findings. The sensitivity, specificity, and positive and negative predictive values of T1 and T2 assessment of cerebral lamination were calculated. RESULTS: Twenty-six fetuses had abnormal and 29 had normal cerebral lamination on histology. On T1, the overall sensitivity, specificity, and positive and negative predictive values of evaluating cerebral lamination were 96.15%(CI, 78.42%–99.80%), 89.66%(CI, 71.50%–97.29%), 89.29%(CI, 70.63%–97.19%), and 96.29%(CI, 79.11%–99.80%), respectively. On T2, the overall sensitivity, specificity, and positive and negative predictive values of evaluating cerebral lamination were 73.08%(CI, 51.95%–87.65%), 96.55%(CI, 80.37%–99.82%), 95.00%(CI, 73.06%–99.74%), and 80.00%(CI, 62.54%–90.94%), respectively. CONCLUSIONS: Postmortem MR imaging has high sensitivity, specificity, and positive and negative predictive values in assessing fetal cerebral lamination compared with histology. T1-weighted imaging has a higher sensitivity and negative predictive value, while T2-weighted imaging has a higher specificity and positive predictive value. Abbreviations: C, cortex • CI, confidence interval • G, germinal matrix • I, intermediate zone • MRI, MR imaging • NPV, negative predictive value • PPV, positive predictive value • S, subplate layer Home Subscribe Author Instructions Submit Online Search the AJNR Archives Feedback Help Copyright © 2010 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X

Journal

American Journal of NeuroradiologyAmerican Journal of Neuroradiology

Published: Nov 1, 2010

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