Access the full text.
Sign up today, get DeepDyve free for 14 days.
(1976)
Embedding in Agar/paraffin
E. Widjaja, S. Geibprasert, S. Blaser, T. Rayner, P. Shannon (2009)
Abnormal fetal cerebral laminar organization in cobblestone complex as seen on post-mortem MRI and DTIPediatric Radiology, 39
P. Griffiths, Dick Variend, M. Evans, Angharad Jones, I. Wilkinson, M. Paley, E. Whitby (2003)
Postmortem MR imaging of the fetal and stillborn central nervous system.AJNR. American journal of neuroradiology, 24 1
I. Kostović, M. Judas, M. Radoš, P. Hrabac (2002)
Laminar organization of the human fetal cerebrum revealed by histochemical markers and magnetic resonance imaging.Cerebral cortex, 12 5
Paula Woodward, Roya Sohaey, Dale Harris, G. Jackson, Edward Klatt, Andrew Alexander, Anne Kennedy (1997)
Postmortem fetal MR imaging: comparison with findings at autopsy.AJR. American journal of roentgenology, 168 1
M. Radoš, M. Judas, I. Kostović (2006)
In vitro MRI of brain development.European journal of radiology, 57 2
C. Hilgetag, H. Barbas (2005)
Developmental mechanics of the primate cerebral cortexAnatomy and Embryology, 210
O. Glenn (2009)
MR imaging of the fetal brainPediatric Radiology, 40
Elysa Widjaja, S. Geibprasert, S. Mahmoodabadi, Susan Blaser, N. Brown, Patrick Shannon (2010)
Alteration of Human Fetal Subplate Layer and Intermediate Zone During Normal Development on MR and Diffusion Tensor ImagingAmerican Journal of Neuroradiology, 31
Brian Chong, C. Babcook, M. Salama, William Nemzek, Dan Kroeker, William Ellis (1996)
A magnetic resonance template for normal neuronal migration in the fetus.Neurosurgery, 39 1
J. Keeling (1989)
Development of the Human Fetal Brain. An Anatomical AtlasArchives of Disease in Childhood, 64
P. Rakic (1978)
Neuronal migration and contact guidance in the primate telencephalon.Postgraduate medical journal, 54 Suppl 1
A. Barkovich, P. Gressens, P. Evrard (1992)
Formation, maturation, and disorders of brain neocortex.AJNR. American journal of neuroradiology, 13 2
This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: ajnr.A2193v1 31/10/1987 most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Google Scholar Articles by Widjaja, E. Articles by Shannon, P. PubMed PubMed Citation Articles by Widjaja, E. Articles by Shannon, P. Hotlight (NEW!) What's Hotlight? American Journal of Neuroradiology 31:1987-1993, November-December 2010 © 2010 American Society of Neuroradiology PEDIATRICS Corroboration of Normal and Abnormal Fetal Cerebral Lamination on Postmortem MR Imaging with Postmortem Examination E. Widjaja a , S. Geibprasert a , S. Zarei Mahmoodabadi a , N.E. Brown a and P. Shannon b a From the Department of Diagnostic Imaging (E.W., S.G., S.Z.M., N.E.B.), Hospital for Sick Children, Toronto, Ontario, Canada b Department of Pathology (P.S.), Mount Sinai Hospital, Toronto, Ontario, Canada Please address correspondence to Elysa Widjaja, MD, Department of Diagnostic Imaging, Hospital for Sick Children, 555 University Ave, Toronto, Ontario M5G 1X8, Canada; e-mail: Elysa.Widjaja@sickkids.ca BACKGROUND AND PURPOSE: The presence of normal fetal cerebral lamination of the germinal matrix, intermediate zone, subplate layer, and cortex can be used as a marker of normal fetal cerebral development. Our aim was to compare postmortem MR imaging assessment of normal and abnormal fetal cerebral lamination on T1- and T2-weighted images with histopathology. MATERIALS AND METHODS: Fifty-five formalin-fixed brains from postmortem fetuses, ranging from 16 to 30 weeks' gestational age, mean of 23 weeks, underwent T1- and T2- weighted MR imaging and subsequent sectioning and histologic examination. The cerebral lamination was graded as normal or abnormal on T1- and T2-weighted imaging and compared with postmortem findings. The sensitivity, specificity, and positive and negative predictive values of T1 and T2 assessment of cerebral lamination were calculated. RESULTS: Twenty-six fetuses had abnormal and 29 had normal cerebral lamination on histology. On T1, the overall sensitivity, specificity, and positive and negative predictive values of evaluating cerebral lamination were 96.15%(CI, 78.42%–99.80%), 89.66%(CI, 71.50%–97.29%), 89.29%(CI, 70.63%–97.19%), and 96.29%(CI, 79.11%–99.80%), respectively. On T2, the overall sensitivity, specificity, and positive and negative predictive values of evaluating cerebral lamination were 73.08%(CI, 51.95%–87.65%), 96.55%(CI, 80.37%–99.82%), 95.00%(CI, 73.06%–99.74%), and 80.00%(CI, 62.54%–90.94%), respectively. CONCLUSIONS: Postmortem MR imaging has high sensitivity, specificity, and positive and negative predictive values in assessing fetal cerebral lamination compared with histology. T1-weighted imaging has a higher sensitivity and negative predictive value, while T2-weighted imaging has a higher specificity and positive predictive value. Abbreviations: C, cortex CI, confidence interval G, germinal matrix I, intermediate zone MRI, MR imaging NPV, negative predictive value PPV, positive predictive value S, subplate layer Home Subscribe Author Instructions Submit Online Search the AJNR Archives Feedback Help Copyright © 2010 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X
American Journal of Neuroradiology – American Journal of Neuroradiology
Published: Nov 1, 2010
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.