Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

A New Canine Carotid Artery Bifurcation Aneurysm Model for the Evaluation of Neurovascular Devices

A New Canine Carotid Artery Bifurcation Aneurysm Model for the Evaluation of Neurovascular Devices This Article Free to Access Figures Only Full Text Full Text (PDF) All Versions of this Article: ajnr.A1929v1 31/5/967 most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Google Scholar Articles by Naggara, O. Articles by Raymond, J. PubMed PubMed Citation Articles by Naggara, O. Articles by Raymond, J. Hotlight (NEW!) What's Hotlight? American Journal of Neuroradiology 31:967-971, May 2010 © 2010 American Society of Neuroradiology INTERVENTIONAL A New Canine Carotid Artery Bifurcation Aneurysm Model for the Evaluation of Neurovascular Devices O. Naggara a , T.E. Darsaut a , I. Salazkin a , G. Soulez a , F. Guilbert a , D. Roy a , A. Weill a , G. Gevry a and J. Raymond a a From the Interventional Neuroradiology Research Unit, Department of Radiology, Centre Hospitalier de l'Université de Montréal, Notre-Dame Hospital, Montreal, Canada. Please address correspondence to Jean Raymond, MD, CHUM–Notre-Dame Hospital, Interventional Neuroradiology Research Lab (NRI), 1560 Sherbrooke East, Pavilion Simard, Suite Z12909, Montreal, QC H2L 4M1, Canada; e-mail: jean.raymond@umontreal.ca BACKGROUND AND PURPOSE: Stents are increasingly used for coiling of difficult aneurysms, to reduce the risk of recurrences, or to modify blood flow. Currently available bifurcation aneurysm models are ill-suited to assess stent performance before clinical use. We designed a new wide-neck canine T-type bifurcation aneurysm model. Its potential value as a training tool as well as in the evaluation of new techniques or embolic agents was assessed. Our first task was to verify that recurrences occurred after satisfactory coiling. A second aim of this preliminary work was to assess if the new model could recreate the technical challenges involved in bifurcation aneurysms. MATERIALS AND METHODS: We introduce a new canine wide-neck bifurcation aneurysm model, created by using a vein pouch at the apex of an end-to-side anastomosis of the carotid arteries, with flow reversal in the proximal RCA by ligation of the innominate artery. Three aneurysms were treated with coil embolization, 10 were treated with stents (7 self-expandable, 3 balloon-expandable), and 3 were left untreated. Aneurysms were followed by duplex ultrasonography and angiography, and studied with macroscopic photography after euthanasia 11.8 ± 3.9 months after surgery. RESULTS: All aneurysms remained patent at 9.0 ± 3.6 months' follow-up. Coiling led to recurrences by 3 months in all 3 cases. Stent placement was technically difficult in all cases and did not lead to aneurysm thrombosis or neointimal closure of the aneurysm neck at 3 months. CONCLUSIONS: This model may be suitable for studying the effects of endovascular treatment on aneurysm and branch occlusion rates, for preclinical testing of stents and other intravascular devices, and for training students of endovascular technique. Abbreviations: %IT, innominate trunk • LCA, left carotid artery • RCA, right carotid artery • SCA, subclavian artery • VP, venous pouch Home Subscribe Author Instructions Submit Online Search the AJNR Archives Feedback Help Copyright © 2010 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

A New Canine Carotid Artery Bifurcation Aneurysm Model for the Evaluation of Neurovascular Devices

Download PDF
5 pages

Loading next page...
 
/lp/american-journal-of-neuroradiology/a-new-canine-carotid-artery-bifurcation-aneurysm-model-for-the-Ty9NLGDbfO

References (17)

Publisher
American Journal of Neuroradiology
Copyright
Copyright © 2010 by the American Society of Neuroradiology.
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A1929
Publisher site
See Article on Publisher Site

Abstract

This Article Free to Access Figures Only Full Text Full Text (PDF) All Versions of this Article: ajnr.A1929v1 31/5/967 most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Google Scholar Articles by Naggara, O. Articles by Raymond, J. PubMed PubMed Citation Articles by Naggara, O. Articles by Raymond, J. Hotlight (NEW!) What's Hotlight? American Journal of Neuroradiology 31:967-971, May 2010 © 2010 American Society of Neuroradiology INTERVENTIONAL A New Canine Carotid Artery Bifurcation Aneurysm Model for the Evaluation of Neurovascular Devices O. Naggara a , T.E. Darsaut a , I. Salazkin a , G. Soulez a , F. Guilbert a , D. Roy a , A. Weill a , G. Gevry a and J. Raymond a a From the Interventional Neuroradiology Research Unit, Department of Radiology, Centre Hospitalier de l'Université de Montréal, Notre-Dame Hospital, Montreal, Canada. Please address correspondence to Jean Raymond, MD, CHUM–Notre-Dame Hospital, Interventional Neuroradiology Research Lab (NRI), 1560 Sherbrooke East, Pavilion Simard, Suite Z12909, Montreal, QC H2L 4M1, Canada; e-mail: jean.raymond@umontreal.ca BACKGROUND AND PURPOSE: Stents are increasingly used for coiling of difficult aneurysms, to reduce the risk of recurrences, or to modify blood flow. Currently available bifurcation aneurysm models are ill-suited to assess stent performance before clinical use. We designed a new wide-neck canine T-type bifurcation aneurysm model. Its potential value as a training tool as well as in the evaluation of new techniques or embolic agents was assessed. Our first task was to verify that recurrences occurred after satisfactory coiling. A second aim of this preliminary work was to assess if the new model could recreate the technical challenges involved in bifurcation aneurysms. MATERIALS AND METHODS: We introduce a new canine wide-neck bifurcation aneurysm model, created by using a vein pouch at the apex of an end-to-side anastomosis of the carotid arteries, with flow reversal in the proximal RCA by ligation of the innominate artery. Three aneurysms were treated with coil embolization, 10 were treated with stents (7 self-expandable, 3 balloon-expandable), and 3 were left untreated. Aneurysms were followed by duplex ultrasonography and angiography, and studied with macroscopic photography after euthanasia 11.8 ± 3.9 months after surgery. RESULTS: All aneurysms remained patent at 9.0 ± 3.6 months' follow-up. Coiling led to recurrences by 3 months in all 3 cases. Stent placement was technically difficult in all cases and did not lead to aneurysm thrombosis or neointimal closure of the aneurysm neck at 3 months. CONCLUSIONS: This model may be suitable for studying the effects of endovascular treatment on aneurysm and branch occlusion rates, for preclinical testing of stents and other intravascular devices, and for training students of endovascular technique. Abbreviations: %IT, innominate trunk • LCA, left carotid artery • RCA, right carotid artery • SCA, subclavian artery • VP, venous pouch Home Subscribe Author Instructions Submit Online Search the AJNR Archives Feedback Help Copyright © 2010 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X

Journal

American Journal of Neuroradiology – American Journal of Neuroradiology

Published: May 1, 2010

There are no references for this article.