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Insights into Adult Postlesional Language Cortical Plasticity Provided by Cerebral Blood Oxygen Level-Dependent Functional MR Imaging

Insights into Adult Postlesional Language Cortical Plasticity Provided by Cerebral Blood Oxygen... This Article Free to Access Figures Only Full Text Full Text (PDF) All Versions of this Article: ajnr.A1896v1 31/6/990 most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Google Scholar Articles by Pillai, J. J. PubMed PubMed Citation Articles by Pillai, J. J. Hotlight (NEW!) What's Hotlight? American Journal of Neuroradiology 31:990-996, June-July 2010 © 2010 American Society of Neuroradiology REVIEW ARTICLES Insights into Adult Postlesional Language Cortical Plasticity Provided by Cerebral Blood Oxygen Level–Dependent Functional MR Imaging J.J. Pillai a a From the Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland. Please address correspondence to Jay J. Pillai, MD, Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Hospital, Phipps Building, B-100, 600 N Wolfe St, Baltimore, MD 21287; e-mail: jpillai1@jhmi.edu SUMMARY: BOLD fMRI has provided new insights into postlesional brain language plasticity by providing a noninvasive in vivo approach to evaluate longitudinal changes in brain cortical activation during performance of language tasks. Specifically, BOLD fMRI has provided the opportunity to investigate not only changes in eloquent language cortex resulting from different types of brain pathology such as brain tumors, stroke, and epilepsy but also changes in eloquent language cortex occurring as a result of actual surgical resection of diseased but, nevertheless, partially functional tissue. In addition to reviewing the literature relating to stroke and epilepsy-related language plasticity as well as the more intriguing phenomenon of postsurgical plasticity in the setting of brain tumors, 2 unusual cases illustrating this latter manifestation of language plasticity are briefly described in this review article. Abbreviations: BOLD, blood oxygen level–dependent • DECS, direct electrical cortical stimulation (intraoperative mapping) • fMRI, functional MR imaging • GABA, gamma-aminobutyric acid (neurotransmitter) • L, left • LI, laterality index • LIFG, left inferior frontal gyrus • MPRAGE, magnetization-prepared rapid acquisition gradient echo • NV, noun-verb (association) • P, phonological (rhyming) • PET, positron-emission tomography • R, right • RIFG, right inferior frontal gyrus • S1, first (preoperative) fMRI scanning session • S2, second (first postoperative) fMRI scanning session • S3, third (second postoperative) fMRI scanning session • SPM, Statistical Parametric Mapping • TLE, temporal lobe epilepsy Home Subscribe Author Instructions Submit Online Search the AJNR Archives Feedback Help Copyright © 2010 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

Insights into Adult Postlesional Language Cortical Plasticity Provided by Cerebral Blood Oxygen Level-Dependent Functional MR Imaging

Pillai, J.J.
American Journal of Neuroradiology , Volume 31 (6): 990 – Jun 1, 2010
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References (64)

Publisher
American Journal of Neuroradiology
Copyright
Copyright © 2010 by the American Society of Neuroradiology.
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A1896
Publisher site
See Article on Publisher Site

Abstract

This Article Free to Access Figures Only Full Text Full Text (PDF) All Versions of this Article: ajnr.A1896v1 31/6/990 most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Google Scholar Articles by Pillai, J. J. PubMed PubMed Citation Articles by Pillai, J. J. Hotlight (NEW!) What's Hotlight? American Journal of Neuroradiology 31:990-996, June-July 2010 © 2010 American Society of Neuroradiology REVIEW ARTICLES Insights into Adult Postlesional Language Cortical Plasticity Provided by Cerebral Blood Oxygen Level–Dependent Functional MR Imaging J.J. Pillai a a From the Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland. Please address correspondence to Jay J. Pillai, MD, Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Hospital, Phipps Building, B-100, 600 N Wolfe St, Baltimore, MD 21287; e-mail: jpillai1@jhmi.edu SUMMARY: BOLD fMRI has provided new insights into postlesional brain language plasticity by providing a noninvasive in vivo approach to evaluate longitudinal changes in brain cortical activation during performance of language tasks. Specifically, BOLD fMRI has provided the opportunity to investigate not only changes in eloquent language cortex resulting from different types of brain pathology such as brain tumors, stroke, and epilepsy but also changes in eloquent language cortex occurring as a result of actual surgical resection of diseased but, nevertheless, partially functional tissue. In addition to reviewing the literature relating to stroke and epilepsy-related language plasticity as well as the more intriguing phenomenon of postsurgical plasticity in the setting of brain tumors, 2 unusual cases illustrating this latter manifestation of language plasticity are briefly described in this review article. Abbreviations: BOLD, blood oxygen level–dependent • DECS, direct electrical cortical stimulation (intraoperative mapping) • fMRI, functional MR imaging • GABA, gamma-aminobutyric acid (neurotransmitter) • L, left • LI, laterality index • LIFG, left inferior frontal gyrus • MPRAGE, magnetization-prepared rapid acquisition gradient echo • NV, noun-verb (association) • P, phonological (rhyming) • PET, positron-emission tomography • R, right • RIFG, right inferior frontal gyrus • S1, first (preoperative) fMRI scanning session • S2, second (first postoperative) fMRI scanning session • S3, third (second postoperative) fMRI scanning session • SPM, Statistical Parametric Mapping • TLE, temporal lobe epilepsy Home Subscribe Author Instructions Submit Online Search the AJNR Archives Feedback Help Copyright © 2010 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X

Journal

American Journal of Neuroradiology – American Journal of Neuroradiology

Published: Jun 1, 2010

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