Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

MR Spectroscopy Detects Lipid Peaks in Cerebrotendinous Xanthomatosis

MR Spectroscopy Detects Lipid Peaks in Cerebrotendinous Xanthomatosis SUMMARY: CTX is a rare lipid-storage disease. Novel MRS findings from 3 patients, using a short TE, were the presence of lipid peaks at 0.9 and 1.3 ppm in the depth of the cerebellar hemisphere; this might represent an additional marker of disease that is CNS-specific and noninvasive. A decrease in NAA concentration was also detected and attributed to neuroaxonal damage. One patient presented an increase in mIns concentration, pointing to gliosis and astrocytic proliferation. Abbreviations a.u. arbitrary unit Cho choline-containing compounds CNS central nervous system Cr creatine/phosphocreatine CTX cerebrotendinous xanthomatosis Lip lipid Lip09 lipid signals at 0.9 ppm Lip13 lipid signals at 1.3 ppm mIns myo-inositol MRS MR spectroscopy NAA N -acetylaspartate PRESS point-resolved spectroscopy sequence STEAM short echo time stimulated echo acquisition mode VOI volume of interest http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

MR Spectroscopy Detects Lipid Peaks in Cerebrotendinous Xanthomatosis

Loading next page...
 
/lp/american-journal-of-neuroradiology/mr-spectroscopy-detects-lipid-peaks-in-cerebrotendinous-xanthomatosis-yD069AHL7g

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
American Journal of Neuroradiology
Copyright
Copyright © 2010 by the American Society of Neuroradiology.
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A1885
pmid
20150306
Publisher site
See Article on Publisher Site

Abstract

SUMMARY: CTX is a rare lipid-storage disease. Novel MRS findings from 3 patients, using a short TE, were the presence of lipid peaks at 0.9 and 1.3 ppm in the depth of the cerebellar hemisphere; this might represent an additional marker of disease that is CNS-specific and noninvasive. A decrease in NAA concentration was also detected and attributed to neuroaxonal damage. One patient presented an increase in mIns concentration, pointing to gliosis and astrocytic proliferation. Abbreviations a.u. arbitrary unit Cho choline-containing compounds CNS central nervous system Cr creatine/phosphocreatine CTX cerebrotendinous xanthomatosis Lip lipid Lip09 lipid signals at 0.9 ppm Lip13 lipid signals at 1.3 ppm mIns myo-inositol MRS MR spectroscopy NAA N -acetylaspartate PRESS point-resolved spectroscopy sequence STEAM short echo time stimulated echo acquisition mode VOI volume of interest

Journal

American Journal of NeuroradiologyAmerican Journal of Neuroradiology

Published: Aug 1, 2010

References