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William Dillon (1997)
Cryptic vascular malformations: controversies in terminology, diagnosis, pathophysiology, and treatment.AJNR. American journal of neuroradiology, 18 10
P. Porter, R. Willinsky, W. Harper, M. Wallace (1997)
Cerebral cavernous malformations: natural history and prognosis after clinical deterioration with or without hemorrhage.Journal of neurosurgery, 87 2
G. Wurm, M. Schnizer, F. Fellner (2005)
Cerebral Cavernous Malformations Associated with Venous Anomalies: Surgical ConsiderationsOperative Neurosurgery, 57
Sandeep Mittal, Zhanghua Wu, J. Neelavalli, E. Haacke (2008)
Susceptibility-Weighted Imaging: Technical Aspects and Clinical Applications, Part 2American Journal of Neuroradiology, 30
O. Sasaki, Ryuichi Tanaka, T. Koike, A. Koide, T. Koizumi, H. Ogawa (1991)
Excision of cavernous angioma with preservation of coexisting venous angioma. Case report.Journal of neurosurgery, 75 3
P. Maeder, F. Gudinchet, R. Meuli, N. Tribolet (1998)
Development of a cavernous malformation of the brain.AJNR. American journal of neuroradiology, 19 6
P. Lasjaunias, P. Burrows, Chantal Planet (2005)
Developmental venous anomalies (DVA): The so-called venous angiomaNeurosurgical Review, 9
Peter Rivera, R. Willinsky, P. Porter (2003)
Intracranial cavernous malformations.Neuroimaging clinics of North America, 13 1
S. Çakirer (2003)
De novo formation of a cavernous malformation of the brain in the presence of a developmental venous anomaly.Clinical radiology, 58 3
R. Marasco, M. Spagnoli, M. Leonardi (2009)
Association between Developmental Venous Anomalies and Cavernous Angiomas: A Retrospective MR StudyThe Neuroradiology Journal, 22
I. Awad, John Robinson, S. Mohanty, M. Estes (1993)
Mixed vascular malformations of the brain: clinical and pathogenetic considerations.Neurosurgery, 33 2
Guy Wilms, E. Bleus, P. Demaerel, Guy Marchal, C. Plets, Jan Goffin, A. Baert (1994)
Simultaneous occurrence of developmental venous anomalies and cavernous angiomas.AJNR. American journal of neuroradiology, 15 7
Jeffrey Larson, W. Ball, K. Bove, K. Crone, J. Tew (1998)
Formation of intracerebral cavernous malformations after radiation treatment for central nervous system neoplasia in children.Journal of neurosurgery, 88 1
N. Campeau, J. Lane (2005)
De novo development of a lesion with the appearance of a cavernous malformation adjacent to an existing developmental venous anomaly.AJNR. American journal of neuroradiology, 26 1
J. Hsieh, R. Penn (2006)
Intrathecal baclofen in the treatment of adult spasticity.Neurosurgical focus, 21 2
N. Revencu, M. Vikkula (2006)
Cerebral cavernous malformation: new molecular and clinical insightsJournal of Medical Genetics, 43
E. Pozzati, G. Giuliani, Giacomo Nuzzo, M. Poppi (1989)
The growth of cerebral cavernous angiomas.Neurosurgery, 25 1
S. Abdulrauf, M. Kaynar, I. Awad (1999)
A comparison of the clinical profile of cavernous malformations with and without associated venous malformations.Neurosurgery, 44 1
D. Rigamonti, R. Spetzler (1988)
The association of venous and cavernous malformations. Report of four cases and discussion of the pathophysiological, diagnostic, and therapeutic implications.Acta neurochirurgica, 92 1-4
B. Guclu, A. Ozturk, K. Pricola, Aşkın Şeker, M. Ozek, M. Gunel (2005)
Cerebral Venous Malformations Have Distinct Genetic Origin From Cerebral Cavernous MalformationsStroke, 36
B. Karlsson, M. Lindqvist, H. Blomgren, W. Guo, M. Söderman, I. Lax, Masaaki Yamamoto, J. Bailes (2005)
Long-term Results after Fractionated Radiation Therapy for Large Brain Arteriovenous MalformationsNeurosurgery, 57
C. Scamoni, A. Dario, L. Basile (1997)
The association of cavernous and venous angioma. Case report and review of the literature.British journal of neurosurgery, 11 4
Susan Criswell, Beth Crowner, B. Racette (2006)
The use of botulinum toxin therapy for lower-extremity spasticity in children with cerebral palsy.Neurosurgical focus, 21 2
Stefan Mindea, Benson Yang, R. Shenkar, B. Bendok, H. Batjer, I. Awad (2006)
Cerebral cavernous malformations: clinical insights from genetic studies.Neurosurgical focus, 21 1
T. Poussaint, J. Siffert, P. Barnes, S. Pomeroy, L. Goumnerova, D. Anthony, S. Sallan, N. Tarbell (1995)
Hemorrhagic vasculopathy after treatment of central nervous system neoplasia in childhood: diagnosis and follow-up.AJNR. American journal of neuroradiology, 16 4
J. Zabramski, T. Wascher, R. Spetzler, Blake Johnson, J. Golfinos, B. Drayer, Ben Brown, D. Rigamonti, Geraldine Brown (1994)
The natural history of familial cavernous malformations: results of an ongoing study.Journal of neurosurgery, 80 3
T. Garner, O. Curling, D. Kelly, D. Laster (1991)
The natural history of intracranial venous angiomas.Journal of neurosurgery, 75 5
T. Abe, R. Singer, M. Marks, A. Norbash, R. Crowley, G. Steinberg (1998)
Coexistence of occult vascular malformations and developmental venous anomalies in the central nervous system: MR evaluation.AJNR. American journal of neuroradiology, 19 1
E. Pozzati, F. Giangaspero, Federica Marliani, N. Acciarri (1996)
Occult cerebrovascular malformations after irradiation.Neurosurgery, 39 4
S. Schold (1999)
Russell and Rubenstein's Pathology of Tumors of the Nervous System
E. Haacke, S. Mittal, Zhen Wu, J. Neelavalli, Y. Cheng (2008)
Susceptibility-Weighted Imaging: Technical Aspects and Clinical Applications, Part 1American Journal of Neuroradiology, 30
J. Souza, R. Domingues, L. Cruz, F. Domingues, T. Iasbeck, E. Gasparetto (2008)
Susceptibility-Weighted Imaging for the Evaluation of Patients with Familial Cerebral Cavernous Malformations: A Comparison with T2-Weighted Fast Spin-Echo and Gradient-Echo SequencesAmerican Journal of Neuroradiology, 29
M. Gunel, M. Gunel, I. Awad, K. Finberg, J. Anson, G. Steinberg, H. Batjer, T. Kopitnik, L. Morrison, S. Giannotta, C. Nelson-Williams, R. Lifton, R. Lifton (1996)
A founder mutation as a cause of cerebral cavernous malformation in Hispanic Americans.The New England journal of medicine, 334 15
P. Perrini, G. Lanzino (2006)
The association of venous developmental anomalies and cavernous malformations: pathophysiological, diagnostic, and surgical considerations.Neurosurgical focus, 21 1
BACKGROUND AND PURPOSE: CCMs are commonly associated with DVAs, but the incidence of association in familial CCM is unknown. The presence of a DVA significantly complicates surgical management of a CCM because of the risk of compromised venous drainage. In this investigation, we compared the incidence of a DVA in the presence of a CCM in sporadic and familial CCM cases comprising predominantly familial CCM with the Southwestern US common Hispanic mutation (or Q455X mutation) of CCM1 . MATERIALS AND METHODS: Retrospective review was performed of 112 patients identified with CCM. MR imaging review included the presence or absence of a DVA and number, location, size, and signal-intensity characteristics of CCMs. Record review included patient and family history and documented genetic mutations. Statistical analysis was performed by using the Fisher exact and 2-sample t tests. RESULTS: Eighty-one cases were familial, 18 were sporadic, and 13 were indeterminate. There were a total of 2212 CCMs: 2176, 21, and 15 in the familial, sporadic, and indeterminate groups, respectively. There was a close association of CCM and DVA (an apparent combined vascular lesion) in 8 of 18 (44%) sporadic cases and only 1 possible such association in the familial cases. The difference was highly statistically significant ( P < .0001). CONCLUSIONS: Familial CCMs are unlikely to be associated with DVAs, and sporadic CCMs have a high rate of association with DVA. This difference in imaging features of familial and sporadic CCMs suggests the possibility of a different developmental mechanism. Abbreviations CCM cerebral cavernous malformation DVA developmental venous anomaly FLAIR fluid-attenuated inversion recovery FSE fast spin-echo GR gradient recall SE spin-echo SWI susceptibility-weighted imaging
American Journal of Neuroradiology – American Journal of Neuroradiology
Published: Feb 1, 2010
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