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- Publisher
- American Journal of Neuroradiology
- Copyright
- Copyright © 2010 by the American Society of Neuroradiology.
- ISSN
- 0195-6108
- eISSN
- 1936-959X
- DOI
- 10.3174/ajnr.A1681
- Publisher site
- See Article on Publisher Site
Abstract
This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: ajnr.A1681v1 30/9/1773 most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Wu, C.-M. Articles by Liu, T.-C. Search for Related Content PubMed PubMed Citation Articles by Wu, C.-M. Articles by Liu, T.-C. Hotlight (NEW!) What's Hotlight? American Journal of Neuroradiology 30:1773-1777, October 2009 © 2009 American Society of Neuroradiology HEAD AND NECK Diffusion Tensor Imaging of the Subcortical Auditory Tract in Subjects with Congenital Cochlear Nerve Deficiency C.-M. Wu a , S.-H. Ng b ,c , J.-J. Wang b ,c and T.-C. Liu d a From the Department of Otolaryngology (C.-M.W.), College of Medicine b Molecular Imaging Center (S.-H.N., J.-J.W.) and Departments of Diagnostic Radiology, and Medical Imaging c Radiological Sciences (S.-H.N., J.-J.W.), Chang-Gung University, Linkou, Taiwan d Department of Otolaryngology (T.-C.L.), National Taiwan University Hospital, Taipei, Taiwan. Please address correspondence to: Tien-Chen Liu, MD, Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan; e-mail: liuent@ntu.edu.tw BACKGROUND AND PURPOSE: Cochlear nerve deficiency (CND), including aplasia and hypoplasia, is a rare cause of congenital hearing loss. The purpose of this study was to evaluate the neuronal integrity of the subcortical auditory pathway in subjects with CND by diffusion tensor MR imaging (DTI). MATERIALS AND METHODS: Twelve subjects with unilateral congenital CND were included in this prospective study. Twelve normal-hearing subjects served as controls. DTIs were acquired from these subjects on a 3T MR imaging scanner. Several indices including axial diffusivity ( || ), radial diffusivity ( ), mean diffusivity (MD), and fractional anisotropy (FA) along the auditory pathway were extracted. Two regions of interest were selected bilaterally for evaluation: the lateral lemniscus (LL) and inferior colliculus (IC). The mean values of || , , MD, and FA at both regions of interest were compared between the ipsilateral and contralateral sides of subjects with CND with those in the control group. RESULTS: Significant decrease of FA and increase of MD on both the ipsilateral and contralateral sides of patients with CND as compared with normal subjects in both LL and IC were found. The decrease of FA was due to the increase of , whereas || remained unchanged. CONCLUSIONS: The maintained axial diffusion implied that the orientation of neural fibers along the subcortical auditory pathway in subjects with unilateral CND is intact. However, the reduction in FA and increase in on both the ipsilateral and contralateral sides might be attributed to axonal loss and/or demyelination of the subcortical auditory tract in these subjects. Home Subscribe Author Instructions Submit Online Search the AJNR Archives Feedback Help Copyright © 2010 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X
Journal
American Journal of Neuroradiology – American Journal of Neuroradiology
Published: Oct 1, 2009