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J. Abrahams, M. Forman, M. Grady, S. Diamond (2001)
Delivery of human vascular endothelial growth factor with platinum coils enhances wall thickening and coil impregnation in a rat aneurysm model.AJNR. American journal of neuroradiology, 22 7
A. Molyneux, D. Ellison, J. Morris, J. Byrne (1995)
Histological findings in giant aneurysms treated with Guglielmi detachable coils. Report of two cases with autopsy correlation.Journal of neurosurgery, 83 1
R. Dawson, A. Krisht, D. Barrow, G. Joseph, G. Shengelaia, G. Bonner (1995)
Treatment of Experimental Aneurysms Using Collagen‐coated Microcoils Experimental Study: 133Neurosurgery, 36
D. Dai, Y. Ding, M. Danielson, R. Kadirvel, L. Hunter, W. Zhan, G. Helm, D. Lewis, H. Cloft, G. Sieck, D. Kallmes (2007)
Endovascular Treatment of Experimental Aneurysms by Use of Fibroblast-Coated Platinum Coils: An Angiographic and Histopathologic StudyStroke, 38
D. Kallmes, N. Fujiwara, D. Yuen, D. Dai, Shu-tung Li (2003)
A collagen-based coil for embolization of saccular aneurysms in a New Zealand White rabbit model.AJNR. American journal of neuroradiology, 24 4
C. Evans, I. Trail (1998)
Fibroblast-Like Cells from Tendons Differ from Skin Fibroblasts in their Ability to form Three-Dimensional Structures in VitroJournal of Hand Surgery (British and European Volume), 23
D. Kallmes, M Borland, H. Cloft, T Altes, J Dion, M Jensen, G Hankins, G Helm (1998)
In vitro proliferation and adhesion of basic fibroblast growth factor-producing fibroblasts on platinum coils.Radiology, 206 1
Y. Ding, D. Dai, D. Lewis, H. Cloft, D. Kallmes (2005)
Angiographic and histologic analysis of experimental aneurysms embolized with platinum coils, Matrix, and HydroCoil.AJNR. American journal of neuroradiology, 26 7
Y. Murayama, S. Tateshima, N. Gonzalez, F. Viñuela (2003)
Matrix and Bioabsorbable Polymeric Coils Accelerate Healing of Intracranial Aneurysms: Long-Term Experimental StudyStroke: Journal of the American Heart Association, 34
Y. Murayama, Yoshiaki Suzuki, F. Viñuela, M. Kaibara, K. Kurotobi, M. Iwaki, T. Abe (1999)
Development of a biologically active Guglielmi detachable coil for the treatment of cerebral aneurysms. Part I: in vitro study.AJNR. American journal of neuroradiology, 20 10
T. Altes, H. Cloft, J. Short, A. deGast, H. Do, G. Helm, D. Kallmes (2000)
1999 ARRS Executive Council Award. Creation of saccular aneurysms in the rabbit: a model suitable for testing endovascular devices. American Roentgen Ray Society.AJR. American journal of roentgenology, 174 2
A. Molyneux, R. Kerr, Ly-Mee Yu, M. Clarke, M. Sneade, J. Yarnold, P. Sandercock (2005)
International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised comparison of effects on survival, dependency, seizures, rebleeding, subgroups, and aneurysm occlusionThe Lancet, 366
A. Gast, T. Altes, W. Marx, H. Do, G. Helm, D. Kallmes (2001)
Transforming Growth Factor &bgr;-coated Platinum Coils for Endovascular Treatment of Aneurysms: An Animal StudyNeurosurgery, 49
I. Szikora, A. Wakhloo, L. Guterman, Tamerla Chavis, Robert Dawson, Robert Hergenrother, Robert Twyford, L. Hopkins (1997)
Initial experience with collagen-filled Guglielmi detachable coils for endovascular treatment of experimental aneurysms.AJNR. American journal of neuroradiology, 18 4
Y. Ding, D. Dai, R. Kadirvel, David Lewis, H. Cloft, D. Kallmes (2008)
Relationship Between Aneurysm Volume and Histologic Healing after Coil Embolization in Elastase-Induced Aneurysms: A Retrospective StudyAmerican Journal of Neuroradiology, 29
G. Dahab, MOHAMED Kheriza, Hussien El‐Beltagi, Abdel-Motaal Fouda, OSAMA EL‐DIN (2004)
Digital quantification of fibrosis in liver biopsy sections: Description of a new method by Photoshop softwareJournal of Gastroenterology and Hepatology, 19
J. Abrahams, M. Forman, M. Grady, S. Diamond (2001)
Biodegradable Polyglycolide Endovascular Coils Promote Wall Thickening and Drug Delivery in a Rat Aneurysm ModelNeurosurgery, 49
D. Dai, Y. Ding, D. Lewis, D. Kallmes (2006)
A proposed ordinal scale for grading histology in elastase-induced, saccular aneurysms.AJNR. American journal of neuroradiology, 27 1
D. Kallmes, Armistead Williams, H. Cloft, M. Lopes, G. Hankins, G. Helm (1998)
Platinum coil-mediated implantation of growth factor-secreting endovascular tissue grafts: an in vivo study.Radiology, 207 2
Gregory Helm, J. Li, Tord Alden, Sarah Hudson, E. Beres, Mary Cunningham, Mark Mikkelsen, Debra Pittman, K. Kerns, D. Kallmes (2000)
A light and electron microscopic study of ectopic tendon and ligament formation induced by bone morphogenetic protein-13 adenoviral gene therapy.Journal of neurosurgery, 95 2
A. Gruber, M. Killer, G. Bavinzski, B. Richling (1999)
Clinical and angiographic results of endosaccular coiling treatment of giant and very large intracranial aneurysms: a 7-year, single-center experience.Neurosurgery, 45 4
Y. Murayama, Fernando Vi??uela, Yoshiaki Suzuki, Huy &NA;, T. Massoud, G. Guglielmi, C. Ji, M. Iwaki, M. Kusakabe, M. Kamio, T. Abe (1997)
Ion implantation and protein coating of detachable coils for endovascular treatment of cerebral aneurysms: concepts and preliminary results in swine models.Neurosurgery, 40 6
D. Dai, Y. Ding, M. Danielson, R. Kadirvel, D. Lewis, H. Cloft, D. Kallmes (2005)
Modified histologic technique for processing metallic coil-bearing tissue.AJNR. American journal of neuroradiology, 26 8
T. Altes, H. Cloft, J. Short, A. deGast, H. Do, G. Helm, D. Kallmes (2000)
Creation of Saccular Aneurysms in the RabbitAmerican Journal of Roentgenology
H. Cloft, D. Kallmes (2004)
Aneurysm packing with HydroCoil Embolic System versus platinum coils: initial clinical experience.AJNR. American journal of neuroradiology, 25 1
BACKGROUND AND PURPOSE: Modified coils have failed to improve long-term recanalization of aneurysms. This study examined whether ex vivo transduction of replication-deficient adenovirus containing the bone morphogenetic protein-13 gene (Ad-BMP-13) in fibroblast allografts would improve angiographic results via increased collagen synthesis, compared with fibroblast-coated platinum coils (FBC) and bare platinum coils (PA). Materials and METHODS: Aneurysms were embolized with Ad-BMP-13-coated coils ( n = 20). Rabbits were sacrificed at 14 days and at 1, 3, and 6 months after implantation. Digital subtraction angiography (DSA) evaluated stability after embolization. Histologic specimens were examined with a qualitative grading system. Masson trichrome evaluated collagen deposition. Findings were compared with previously reported controls for PA and FBC in the same model and time points. RESULTS: The grading system showed a greater total score ( P = .0002) in Ad-BMP-13 (6.8 ± 1.6) and FBC (6.3 ± 2.4) compared with PA (4.7 ± 2.4). A group main effects test showed that aneurysm neck tissue coverage in Ad-BMP-13 (2.5 ± 1.1) was higher ( P = .0007) than both FBC (1.6 ± 1.4) and PA (0.9 ± 1.1). Ad-BMP-13 had more ( P < .0001) collagen deposition than the FBC and PA. One- and 3-month Ad-BMP-13 collagen depositions increased ( P < .05) over the FBC and PA. Finally, Ad-BMP-13 showed radiographic stability in 15 (75%) cases, coil compaction in 4 (20%) cases, and progressive occlusion in 1 (5%) case. There were no differences in angiographic results ( P = .6522). CONCLUSION: The Ad-BMP-13-coated coils can improve neck coverage and dome fibrosis in the rabbit model, even in the absence of observed differences in angiographic outcome.
American Journal of Neuroradiology – American Journal of Neuroradiology
Published: Apr 1, 2008
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