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Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 4 Years — Early Autism and Developmental Disabilities Monitoring Networ ...

Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 4 Years — Early... Morbidity and Mortality Weekly Report Surveillance Summaries / Vol. 68 / No. 2 April 12, 2019 Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 4 Years — Early Autism and Developmental Disabilities Monitoring Network, Seven Sites, United States, 2010, 2012, and 2014 U.S. Department of Health and Human Services Centers for Disease Control and Prevention Surveillance Summaries CONTENTS Introduction ............................................................................................................ 2 Methods .................................................................................................................... 3 Results ....................................................................................................................... 8 Discussion ............................................................................................................. 10 Limitations ............................................................................................................ 12 Conclusion ............................................................................................................ 13 References ............................................................................................................. 13 Appendix ............................................................................................................... 15 The MMWR series of publications is published by the Center for Surveillance, Epidemiology, and Laboratory Services, Centers for Disease Control and Prevention (CDC), U.S. Department of Health and Human Services, Atlanta, GA 30329-4027. Suggested citation: [Author names; first three, then et al., if more than six.] [Title]. MMWR Surveill Summ 2019;68(No. SS-#):[inclusive page numbers]. Centers for Disease Control and Prevention Robert R. Redfield, MD, Director Anne Schuchat, MD, Principal Deputy Director Chesley L. Richards, MD, MPH, Deputy Director for Public Health Science and Surveillance Rebecca Bunnell, PhD, MEd, Director, Office of Science Barbara Ellis, PhD, MS, Acting Director, Office of Science Quality, Office of Science Michael F. Iademarco, MD, MPH, Director, Center for Surveillance, Epidemiology, and Laboratory Services MMWR Editorial and Production Staff (Serials) Charlotte K. Kent, PhD, MPH, Editor in Chief Martha F. Boyd, Lead Visual Information Specialist Christine G. Casey, MD, Editor Maureen A. Leahy, Julia C. Martinroe, Mary Dott, MD, MPH, Online Editor Stephen R. Spriggs, Tong Yang, Teresa F. Rutledge, Managing Editor Visual Information Specialists David C. Johnson, Lead Technical Writer-Editor Quang M. Doan, MBA, Phyllis H. King, Catherine B. Lansdowne, MS, Project Editor Terraye M. Starr, Moua Yang, Information Technology Specialists MMWR Editorial Board Timothy F. Jones, MD, Chairman Matthew L. Boulton, MD, MPH Robin Ikeda, MD, MPH Stephen C. Redd, MD Virginia A. Caine, MD Phyllis Meadows, PhD, MSN, RN Patrick L. Remington, MD, MPH Katherine Lyon Daniel, PhD Jewel Mullen, MD, MPH, MPA Carlos Roig, MS, MA Jonathan E. Fielding, MD, MPH, MBA Jeff Niederdeppe, PhD William Schaffner, MD David W. Fleming, MD Patricia Quinlisk, MD, MPH Morgan Bobb Swanson, BS William E. Halperin, MD, DrPH, MPH Surveillance Summaries Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 4 Years — Early Autism and Developmental Disabilities Monitoring Network, Seven Sites, United States, 2010, 2012, and 2014 1 1 2 3 4 Deborah L. Christensen, PhD ; Matthew J. Maenner, PhD ; Deborah Bilder, MD ; John N. Constantino, MD ; Julie Daniels, PhD ; 5 3 6 6 7 Maureen S. Durkin, PhD ; Robert T. Fitzgerald, PhD ; Margaret Kurzius-Spencer, PhD ; Sydney D. Pettygrove, PhD ; Cordelia Robinson, PhD ; 8 9 8 1 1 Josephine Shenouda, MS ; Tiffany White, PhD ; Walter Zahorodny, PhD ; Karen Pazol, PhD ; Patricia Dietz, DrPH Division of Congenital and Developmental Disorders, National Center on Birth Defects and Developmental Disabilities, CDC University of Utah, Salt Lake City Washington University in St. Louis, Missouri University of North Carolina, Chapel Hill University of Wisconsin, Madison University of Arizona, Tucson University of Colorado School of Medicine, Aurora Rutgers New Jersey Medical School, Newark Colorado Department of Public Health and Environment, Denver Abstract Problem/Condition: Autism spectrum disorder (ASD) is estimated to affect up to 3% of children in the United States. Public health surveillance for ASD among children aged 4 years provides information about trends in prevalence, characteristics of children with ASD, and progress made toward decreasing the age of identification of ASD so that evidence-based interventions can begin as early as possible. Period Covered: 2010, 2012, and 2014. Description of System: The Early Autism and Developmental Disabilities Monitoring (Early ADDM) Network is an active surveillance system that provides biennial estimates of the prevalence and characteristics of ASD among children aged 4 years whose parents or guardians lived within designated sites. During surveillance years 2010, 2012, or 2014, data were collected in seven sites: Arizona, Colorado, Missouri, New Jersey, North Carolina, Utah, and Wisconsin. The Early ADDM Network is a subset of the broader ADDM Network (which included 13 total sites over the same period) that has been conducting ASD surveillance among children aged 8 years since 2000. Each Early ADDM site covers a smaller geographic area than the broader ADDM Network. Early ADDM ASD surveillance is conducted in two phases using the same methods and project staff members as the ADDM Network. The first phase consists of reviewing and abstracting data from children’s records, including comprehensive evaluations performed by community professionals. Sources for these evaluations include general pediatric health clinics and specialized programs for children with developmental disabilities. In addition, special education records (for children aged ≥3 years) were reviewed for Arizona, Colorado, New Jersey, North Carolina, and Utah, and early intervention records (for children aged 0 to <3 years) were reviewed for New Jersey, North Carolina, Utah, and Wisconsin; in Wisconsin, early intervention records were reviewed for 2014 only. The second phase involves a review of the abstracted evaluations by trained clinicians using a standardized case definition and method. A child is considered to meet the surveillance case definition for ASD if one or more comprehensive evaluations of that child completed by a qualified professional describes behaviors consistent with the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision (DSM-IV-TR) diagnostic criteria for any of the following conditions: autistic disorder, pervasive developmental disorder–not otherwise specified (PDD-NOS, including atypical autism), or Asperger disorder (2010, 2012, and 2014). For 2014 only, prevalence estimates based on surveillance case definitions according to DSM-IV-TR and the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) were compared. This report provides estimates of overall ASD prevalence and prevalence by sex and race/ethnicity; characteristics of children aged 4 years with ASD, including age at first developmental evaluation, age at ASD diagnosis, and cognitive function; and trends in ASD prevalence and characteristics among Early ADDM sites with data for all 3 surveillance years (2010, 2012, and 2014), including comparisons with children aged 8 years living in the same geographic area. Analyses of time trends in ASD prevalence are restricted to the three sites that contributed data for all 3 surveillance years with consistent data sources (Arizona, Missouri, and New Jersey). US Department of Health and Human Services/Centers for Disease Control and Prevention MMWR / April 12, 2019 / Vol. 68 / No. 2 1 Surveillance Summaries Results: The overall ASD prevalence was 13.4 per 1,000 children aged 4 years in 2010, 15.3 in 2012, and 17.0 in 2014 for Early ADDM sites with data for the specific years. ASD prevalence was determined using a surveillance case definition based on DSM-IV-TR. Within each surveillance year, ASD prevalence among children aged 4 years varied across surveillance sites and was lowest each year for Missouri (8.5, 8.1, and 9.6 per 1,000, for 2010, 2012, and 2014, respectively) and highest each year for New Jersey (19.7, 22.1, and 28.4 per 1,000, for the same years, respectively). Aggregated prevalence estimates were higher for sites that reviewed education and health care records than for sites that reviewed only health care records. Among all participating sites and years, ASD prevalence among children aged 4 years was consistently higher among boys than girls; prevalence ratios ranged from 2.6 (Arizona and Wisconsin in 2010) to 5.2 boys per one girl (Colorado in 2014). In 2010, ASD prevalence was higher among non-Hispanic white children than among Hispanic children in Arizona and non-Hispanic black children in Missouri; no other differences were observed by race/ethnicity. Among four sites with ≥60% data on cognitive test scores (Arizona, New Jersey, North Carolina, and Utah), the frequency of co-occurring intellectual disabilities was significantly higher among children aged 4 years than among those aged 8 years for each site in each surveillance year except Arizona in 2010. The percentage of children with ASD who had a first evaluation by age 36 months ranged from 48.8% in Missouri in 2012 to 88.9% in Wisconsin in 2014. The percentage of children with a previous ASD diagnosis from a community provider varied by site, ranging from 43.0% for Arizona in 2012 to 86.5% for Missouri in 2012. The median age at earliest known ASD diagnosis varied from 28 months in North Carolina in 2014 to 39.0 months in Missouri and Wisconsin in 2012. In 2014, the ASD prevalence based on the DSM-IV-TR case definition was 20% higher than the prevalence based on the DSM-5 (17.0 versus 14.1 per 1,000, respectively). Trends in ASD prevalence and characteristics among children aged 4 years during the study period were assessed for the three sites with data for all 3 years and consistent data sources (Arizona, Missouri, and New Jersey) using the DSM-IV-TR case definition; prevalence was higher in 2014 than in 2010 among children aged 4 years in New Jersey and was stable in Arizona and Missouri. In Missouri, ASD prevalence was higher among children aged 8 years than among children aged 4 years. The percentage of children with ASD who had a comprehensive evaluation by age 36 months was stable in Arizona and Missouri and decreased in New Jersey. In the three sites, no change occurred in the age at earliest known ASD diagnosis during 2010–2014. Interpretation: The findings suggest that ASD prevalence among children aged 4 years was higher in 2014 than in 2010 in one site and remained stable in others. Among children with ASD, the frequency of cognitive impairment was higher among children aged 4 years than among those aged 8 years and suggests that surveillance at age 4 years might more often include children with more severe symptoms or those with co-occurring conditions such as intellectual disability. In the sites with data for all years and consistent data sources, no change in the age at earliest known ASD diagnosis was found, and children received their first developmental evaluation at the same or a later age in 2014 compared with 2010. Delays in the initiation of a first developmental evaluation might adversely affect children by delaying access to treatment and special services that can improve outcomes for children with ASD. Public Health Action: Efforts to increase awareness of ASD and improve the identification of ASD by community providers can facilitate early diagnosis of children with ASD. Heterogeneity of results across sites suggests that community-level differences in evaluation and diagnostic services as well as access to data sources might affect estimates of ASD prevalence and age of identification. Continuing improvements in providing developmental evaluations to children as soon as developmental concerns are identified might result in earlier ASD diagnoses and earlier receipt of services, which might improve developmental outcomes. Introduction Autism spectrum disorder (ASD) is a developmental determined to be at age 8 years. Therefore, subsequent to that disability marked by social and communication impairments, report, CDC has reported ASD prevalence among children as well as restricted interests and repetitive behaviors (1). ASD aged 8 years based on data collected every 2 years from 2000 prevalence has been measured by special education and other through 2014. Surveillance was conducted by MADDSP and administrative records (2–4), national surveys (5–9), and active other sites across the United States that participated in the public health surveillance conducted through the Metropolitan ADDM Network. The most recent ASD prevalence estimate Atlanta Developmental Disabilities Surveillance Program from the ADDM Network was 16.8 per 1,000 children aged (MADDSP) and its extended surveillance network, the 8 years in 2014 (13), compared with 14.5 per 1,000 in 2012 Autism and Developmental Disabilities Monitoring (ADDM) (14) and 14.7 per 1,000 in 2010 (15). Network (10–17). ASD prevalence was first measured by CDC Measuring ASD prevalence and age at diagnosis in elementary among children aged 3–10 years children by MADDSP in school–aged children is expected to yield the most complete 1996 (16). In that analysis, the peak prevalence of ASD was information on ASD prevalence and characteristics (13–15); 2 MMWR / April 12, 2019 / Vol. 68 / No. 2 US Department of Health and Human Services/Centers for Disease Control and Prevention Surveillance Summaries however, measuring ASD prevalence in preschool-aged children seven of these sites also conducted ASD surveillance and provides more timely assessment of efforts to increase awareness reported data for children aged 4 years for at least 1 year. The and early detection of ASD. Evidence linking early treatment Early ADDM Network included areas of Arizona, Colorado, for ASD with improved outcomes (18–21) implies that an Missouri, New Jersey, North Carolina, Utah, and Wisconsin absence or delay in ASD identification could adversely affect (Figure 1). Five Early ADDM sites participated in 2010 and children by delaying interventions and initiation of special 2012, and six sites participated in 2014. Three Early ADDM services. The American Academy of Pediatrics supports early sites (Arizona, Missouri, and New Jersey) contributed data and identification in their recommendation that all children receive had consistent data sources in all 3 surveillance years. ASD screening at ages 18 and 24 months (22). Each state has Because of resource constraints, Early ADDM surveillance programs to identify children with disabilities and provide was not conducted for the total geographic area covered by special services from birth through age 2 years; children at each study site’s ADDM surveillance for children aged 8 years; risk for or with disabilities are eligible for early intervention rather, each Early ADDM Network surveillance area was a services through part C of the Individuals with Disabilities subset of the site’s total ADDM surveillance area. Each Early Education Act (IDEA) (http://idea.ed.gov). Children aged ADDM surveillance area included at least 8,000 children ≥3 years with disabilities are eligible for evaluation and special aged 4 years and a similar number of children aged 8 years. In education services through part B of IDEA, and these services comparison, the total ADDM surveillance areas for children are provided by public school systems (http://idea.ed.gov). aged 8 years for each site included 9,767–51,161 children. The This report describes ASD prevalence estimates and Early ADDM surveillance areas were not random subsets of the characteristics among children aged 4 years in the Early total surveillance areas for the respective sites but were selected ADDM Network for 2010, 2012, and 2014. Selected trend to form areas of full counties or school districts, within the total analyses also are presented. The findings in this report can ADDM surveillance area that met or exceeded the minimum be used by pediatric health care providers, early intervention population size of 8,000 children aged 4 years. Therefore, service providers, therapists, school psychologists, educators, prevalence estimates for children aged 4 years generated by researchers, policymakers, and program administrators seeking the Early ADDM Network should not be interpreted as being to understand and provide for the needs of persons with ASD representative of the prevalence among children aged 4 years and their families. These data can be used to help plan for for the total ADDM study area at a given site. service needs and initiate and implement policies that promote Children included in this analysis were born in 2006, 2008, early identification of children with ASD. or 2010 for the surveillance years 2010, 2012, and 2014, respectively, and had a parent or guardian who lived in the Early ADDM Network surveillance area during all or part of the specific surveillance year. Participating Early ADDM sites were Methods selected through a competitive review process and were not To estimate the prevalence of ASD in a younger age group, selected to be nationally representative. A diverse population seven of the 13 ADDM sites that conducted ASD surveillance was preferred during the review process. Each ADDM site among children aged 8 years during 2010, 2012, 2014 (or all functioned as a public health authority under HIPAA (the these years) also collected ASD surveillance data for children Health Insurance Portability and Accountability Act of 1996) aged 4 years. These sites are collectively known as the Early and met applicable local Institutional Review Board, privacy, ADDM Network. The data for children aged 4 years were and confidentiality requirements (24). collected in subsets of the ADDM geographic areas for children aged 8 years. Case Ascertainment ADDM is an active surveillance system that does not Study Sites depend on family or professional reporting of an existing ASD The ADDM Network uses a multisite, multiple-source, diagnosis or classification to determine ASD case status. Case records-based surveillance method based on a model developed determination is a two-phase process. The first phase involves by CDC’s MADDSP (16,23). In 2010, 2012, and 2014, a total review and abstraction of records at multiple data sources in of 13 sites contributed data to the ADDM Network of ASD the community. In the second phase, all abstracted evaluations surveillance among children aged 8 years for at least 1 year are compiled and reviewed by trained study personnel to (Alabama, Arizona, Arkansas, Colorado, Georgia, Maryland, determine ASD case status. Data sources are categorized as Minnesota, Missouri, New Jersey, North Carolina, Tennessee, either 1) education source type, including evaluations to Utah, and Wisconsin). As part of the Early ADDM Network, US Department of Health and Human Services/Centers for Disease Control and Prevention MMWR / April 12, 2019 / Vol. 68 / No. 2 3 Surveillance Summaries FIGURE 1. Early Autism and Developmental Disabilities Monitoring Network surveillance areas — seven sites, United States, 2010, 2012, and 2014 determine eligibility for special education services or 2) health (ICD-10) billing codes for select childhood disabilities or care source type, including diagnostic and developmental conditions. Children’s records are screened to confirm year evaluations. Evaluations must have been performed by a of birth and residency in the surveillance area at some time qualified professional, such as a psychologist, physician, during the surveillance year. For children meeting age and physical therapist, occupational therapist, speech or language residency requirements, the source files are screened for certain pathologist, or educator. Children’s records are screened from behavioral or diagnostic descriptions defined by ADDM as multiple data sources to determine eligibility for inclusion as a triggers for abstraction (e.g., child does not initiate interactions potential case. Developmental assessments completed by a wide with others, prefers to play alone or engage in solitary range of health care and education providers are reviewed. All activities, or has received a documented ASD diagnosis). If Early ADDM Network sites had agreements in place to access abstraction triggers are found, evaluation information from records at health care sources. Special education records (for birth through the current surveillance year is abstracted into a children aged ≥3 years) were reviewed in Arizona, Colorado, single composite record for each child. The composite record New Jersey, North Carolina, and Utah, and early intervention includes comprehensive evaluations by qualified professionals records (for children aged 0 to <3 years) were reviewed in New from birth through the end of the year when the child reaches Jersey, North Carolina, Utah, and Wisconsin; in Wisconsin, either age 4 or 8 years. early intervention records were reviewed for 2014 only. The In the second phase of surveillance, the abstracted ADDM Network review only includes existing records, not comprehensive evaluations are deidentified and reviewed clinical examinations of children. systematically by clinicians who have undergone standardized In the first phase of surveillance, ADDM Network sites training to determine ASD case status using a coding scheme identify source records to review according to a child’s year of based on the Diagnostic and Statistical Manual of Mental birth and either 1) eligibility classifications in special education Disorders, 4th Edition, Text Revision (DSM-IV-TR) (25) or early intervention, or 2) International Classification of criteria for ASD. These clinicians review each comprehensive Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) evaluation and code the behavioral descriptors according to or International Classification of Diseases, Tenth Revision the DSM-IV-TR criteria represented by the descriptor. 4 MMWR / April 12, 2019 / Vol. 68 / No. 2 US Department of Health and Human Services/Centers for Disease Control and Prevention Surveillance Summaries Surveillance Case Definition Descriptive Characteristics Children included in this analysis were born in 2006, 2008, or Demographic information, including sex and race/ethnicity, 2010 for the surveillance years 2010, 2012, and 2014, respectively, was abstracted. Data on sex were available for all children. and had a parent or guardian who lived in the Early ADDM Data on race/ethnicity were missing for <5% of children Network surveillance area during all or part of the specific across all years, age groups, and surveillance sites. Children surveillance year. A child aged 4 or 8 years met the surveillance with missing race/ethnicity data were not included in analyses case definition for ASD if behaviors described within one or more stratified by race/ethnicity but were included in analyses of all comprehensive evaluations were consistent with the DSM-IV-TR children combined. Each site obtained vital records data for the diagnostic criteria for any of the following conditions: autistic relevant birth year, which were linked to surveillance data to disorder, pervasive developmental disorder–not otherwise specified obtain supplemental information on race/ethnicity and other (PDD-NOS, including atypical autism), or Asperger disorder demographic characteristics. (Box 1). An ASD diagnosis alone was not sufficient to meet the Diagnostic summaries from each evaluation were abstracted DSM-IV-TR surveillance case definition but was considered for each child, including notation of any ASD diagnosis by during the clinician review process, along with behavioral subtype. Children were considered to have an ASD diagnosis criteria. Most records were reviewed by a single person, from a community provider if they received a diagnosis of although clinicians were able to request a second review if they autistic disorder, Asperger disorder, PDD-NOS, or ASD that were uncertain about whether the behaviors were consistent was documented in an abstracted evaluation at any time from with the DSM-IV-TR diagnostic criteria. Children could have birth through the year when they reached age 4 or 8 years. The been disqualified from meeting the case definition if their age at each documented ASD diagnosis from a community behaviors met the surveillance case definition but one or more provider was abstracted, as well as the age at each comprehensive clinician reviewers judged that sufficient information existed to developmental evaluation. These data were used to determine rule out ASD, information to support an ASD diagnosis was the age at the earliest known ASD diagnosis, if any, and the conflicting or insufficient, or that one or more other diagnosed age at the first comprehensive developmental evaluation. Data conditions better accounted for their symptoms. on age at first evaluation were restricted to children who were Updated behavioral criteria for an ASD diagnosis were born in the state where the ADDM Network site was located published in 2013 in the Diagnostic and Statistical Manual to avoid bias from the inability to locate early evaluations for of Mental Disorders, 5th Edition (DSM-5) (1). To determine children who moved into the study area. In-state birth was the effect of the updated DSM-5 behavioral criteria on ASD determined through a successful match to a birth certificate prevalence, a revised surveillance case definition (Box 2) also from that state. If no birth certificate was found, the child was used to classify cases for the 2014 surveillance year. A child was presumed to have been born outside the state where the aged 4 or 8 years met the DSM-5 surveillance case definition if surveillance site was located. Because all children had at least behaviors described within one or more comprehensive evaluations one evaluation, the age at the first evaluation was available for were consistent with the DSM-5 diagnostic criteria or if an all children and is reported as the median age (in months), ASD diagnosis had been documented, regardless of whether the along with the percentage of children with a first evaluation by behavioral criteria had been met. Most records were reviewed by age 36 months. This age was chosen to align with the Healthy a single person, although clinicians were able to request a second People 2020 (http://www.healthypeople.gov/2020/default. review if they were uncertain about whether the behaviors were aspx) goal of increasing the percentage of children with ASD consistent with the DSM-5 diagnostic criteria. Children could who receive their first developmental evaluation by the age of have been disqualified from meeting the case definition if their 36 months. Not all children had a documented ASD diagnosis behaviors met the surveillance case definition but one or more from a community provider; a total of 272 (34.7%), 318 clinician reviewers judged that sufficient information existed to (35.1%), and 508 (42.1%) children had no ASD diagnosis for rule out ASD, information to support an ASD diagnosis was 2010, 2012, and 2014, respectively. The age at earliest known conflicting or insufficient, or that one or more other diagnosed ASD diagnosis could be described only for those children with conditions better accounted for their symptoms. a documented diagnosis and is reported as the median age in In this report, most results are based on the DSM-IV-TR months. Ages of <6 months at earliest known ASD diagnosis surveillance case definition for consistency and comparison were excluded for implausibility (n = 2). across surveillance years. Results comparing ASD prevalence Data were collected on results of standardized tests of using both DSM-IV-TR and DSM-5 surveillance case intellectual ability found in children’s records, and children definitions are included for 2014. were considered to have an intellectual disability if they had US Department of Health and Human Services/Centers for Disease Control and Prevention MMWR / April 12, 2019 / Vol. 68 / No. 2 5 Surveillance Summaries BOX 1. Surveillance case definition based on behavioral criteria for diagnosis of autism spectrum disorder: Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision DSM-IV-TR behavioral criteria Social 1a. Marked impairment in the use of multiple nonverbal behaviors, such as eye-to-eye gaze, facial expression, body postures, and gestures to regulate social interaction 1b. Failure to develop peer relationships appropriate to developmental level 1c. A lack of spontaneous seeking to share enjoyment, interests, or achievements with other people (e.g., by a lack of showing, bringing, or pointing out objects of interest) 1d. Lack of social or emotional reciprocity Communication 2a. Delay in, or total lack of, the development of spoken language (not accompanied by an attempt to compensate through alternative modes of communication, such as gesture or mime) 2b. In individuals with adequate speech, marked impairment in the ability to initiate or sustain a conversation with others 2c. Stereotyped and repetitive use of language or idiosyncratic language 2d. Lack of varied, spontaneous make-believe play or social imitative play appropriate to developmental level Restricted behavior/Interest 3a. Encompassing preoccupation with one or more stereotyped and restricted patterns of interest that is abnormal either in intensity or focus 3b. Apparently inflexible adherence to specific, nonfunctional routines, or rituals 3c. Stereotyped and repetitive motor mannerisms (e.g., hand or finger flapping or twisting, or complex whole body movements) 3d. Persistent preoccupation with parts of objects Developmental history Child had identified delays or any concern with development in the following areas at or before the age of 3 years: Social, Communication, Behavior, Play, Motor, Attention, Adaptive, or Cognitive Autism discriminators Oblivious to children Oblivious to adults or others Rarely responds to familiar social approach Language primarily echolalia or jargon Regression/loss of social, language, or play skills Previous ASD diagnosis, whether based on DSM-IV-TR or DSM-5 diagnostic criteria Lack of showing, bringing, etc. Little or no interest in others Uses others as tools Repeats extensive dialog Absent or impaired imaginative play Markedly restricted interests Unusual preoccupation Insists on sameness Nonfunctional routines Excessive focus on parts Visual inspection Movement preoccupation Sensory preoccupation DSM-IV-TR surveillance case definition At least six behaviors coded with a minimum of two Social, one Communication, and one Restricted Behavior/Interest; AND evidence of developmental delay or concern at or before the age of 3 years OR At least two behaviors coded with a minimum of one Social and either one Communication and/or one Restricted Behavior/Interest; AND at least one autism discriminator coded Note: A child might be disqualified from meeting the DSM-IV-TR surveillance case definition for ASD if, based on the clinical judgment of one or more reviewers, there is insufficient or conflicting information in support of ASD, sufficient information to rule out ASD, or if one or more other diagnosed conditions better account for the child’s symptoms. Abbreviations: ASD = autism spectrum disorder; DSM-IV-TR = Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision; DSM-5= Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. a score of ≤70 on their most recent test. Data on intellectual (n = 114 [18.8%], n = 114 [21.5%], and n = 225 [25.7%] for ability were included for sites for which ≥60% of children 2010, 2012, and 2014, respectively). Uncertainty surrounding meeting the ASD surveillance case definition had an intellectual the reliability of measurement of intellectual ability in early ability test score. Among those sites, children without a test childhood prevents further subclassification of intellectual score were categorized as having unknown intellectual ability ability (26,27). 6 MMWR / April 12, 2019 / Vol. 68 / No. 2 US Department of Health and Human Services/Centers for Disease Control and Prevention Surveillance Summaries BOX 2. Surveillance case definition based on behavioral criteria for diagnosis of autism spectrum disorder*: Diagnostic and Statistical Manual of Mental Disorders, 5th Edition DSM-5 behavioral criteria A. Persistent deficits in social A1: Deficits in social emotional reciprocity communication and social A2. Deficits in nonverbal communicative behaviors interaction A3. Deficits in developing, maintaining, and understanding relationships B. Restricted, repetitive patterns B1: Stereotyped or repetitive motor movements, use of objects or speech of behavior, interests, or B2. Insistence on sameness, inflexible adherence to routines, or ritualized patterns of verbal or nonverbal behavior activities, currently or by B3. Highly restricted interests that are abnormal in intensity or focus history B4. Hyperreactivity or hyporeactivity to sensory input or unusual interest in sensory aspects of the environment Historical pervasive developmental Any ASD diagnosis documented in a comprehensive evaluation, including a DSM-IV diagnosis of autistic disorder, Asperger disorder diagnosis disorder, or pervasive developmental disorder–not otherwise specified DSM-5 surveillance case definition All three behavioral criteria coded under part A, and at least two behavioral criteria coded under part B OR Any ASD diagnosis documented in a comprehensive evaluation, whether based on DSM-IV-TR or DSM-5 diagnostic criteria Note: A child might be disqualified from meeting the DSM-5 surveillance case definition for ASD if, based on the clinical judgment of one or more reviewers, there is insufficient or conflicting information in support of ASD, sufficient information to rule out ASD, or if one or more other diagnosed conditions better account for the child’s symptoms. Abbreviations: ASD = autism spectrum disorder; DSM-IV = Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition; DSM-IV-TR = Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision; DSM-V = Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. * DSM-5 also includes a previous DSM-IV diagnosis of ASD as a sole criterion for a clinical diagnosis. 8 years living in the same geographic areas. Data for 2010 Quality Assurance were previously published (28) but are included in the results All Early ADDM sites follow the same quality assurance to provide a comprehensive representation of ASD prevalence conventions established by the ADDM Network. For the and characteristics for all the years of Early ADDM Network first phase of ADDM, screening and abstraction of source surveillance, as well as a comparison among children from the records are checked periodically for accuracy. For the second sites with data from all 3 surveillance years. phase, interrater reliability receives ongoing monitoring, with The prevalence estimate of ASD among children aged a blinded, random 10% sample of abstracted records that are 4 years was calculated as the number of children aged 4 years scored independently by two reviewers. Across surveillance who met the ASD surveillance case definition in the Early years, the final average interrater agreements for determining ADDM Network sites in 2010, 2012, and 2014 divided by ASD surveillance case status in the Early ADDM study sites the number of children aged 4 years living in the surveillance ranged from 87.3% (κ = 0.74) to 91.1% (κ = 0.81) among areas according to the 2010 decennial bridged-race population children aged 4 years and from 89.2% (κ = 0.77) to 91.0% estimates (29), the vintage 2014 postcensal bridged-race (κ = 0.80) among those aged 8 years. population estimates for 2012 (http://www.cdc.gov/nchs), and the vintage 2016 postcensal bridged-race population estimates Analytic Methods for 2014 (http://www.cdc.gov/nchs). In Arizona and Utah, the surveillance area included some but not all of the school The objectives of this report are to describe ASD prevalence districts in two counties (Maricopa and Salt Lake counties, and characteristics among children aged 4 years in the Early respectively). Therefore, investigators developed a method ADDM Network for 2010, 2012, and 2014, including using census and school district data to estimate the numbers 1) overall prevalence and prevalence by sex and race/ethnicity; of children aged 4 and 8 years living in these surveillance areas. 2) characteristics of children aged 4 years with ASD, including Detailed methods are provided (Appendix). Overall prevalence age at first developmental evaluation, age at ASD diagnosis, estimates included all children identified with ASD regardless and cognitive function; and 3) trends in ASD prevalence of sex, race/ethnicity, or intellectual ability and therefore were and characteristics in the three Early ADDM sites with data unaffected by the availability of these data elements. and consistent data sources for all 3 surveillance years (2010, 2012, and 2014), including comparisons with children aged US Department of Health and Human Services/Centers for Disease Control and Prevention MMWR / April 12, 2019 / Vol. 68 / No. 2 7 Surveillance Summaries Statistical tests and 95% confidence interval (CI) estimates (New Jersey in 2014) to 70.9% (Wisconsin in 2014), and were derived under the assumption that the observed counts the percentage of black children ranged from 3.5% (Arizona of ASD surveillance cases were sampled from an underlying in 2012 and 2014) to 33.1% (New Jersey in 2014). The Poisson distribution. Because previous ADDM Network percentage of Hispanic children ranged from 4.5% (Missouri reports presented CIs based on an underlying Poisson in 2014) to 47.3% (Colorado in 2014). American Indian/ distribution with an asymptotic approximation to the Alaska Native children comprised 0.2%–3.1% of the total normal, slight differences might exist between those and the population, and Asian/Pacific Islander children comprised exact Poisson confidence intervals presented in this report. 2.7%–6.5%. The population distribution by race/ethnicity Generalized linear models with a Poisson distribution were across sites was similar for children aged 8 years. Aggregating used to calculate prevalence ratios (PRs) and CIs. Pearson data across sites for each surveillance year, the total percentages chi-square tests were used to examine frequency differences in by race/ethnicity among children aged 4 years ranged from the characteristics of children with ASD by surveillance area, 46.8% to 51.9% for white (in 2014 and 2010, respectively), sex, race/ethnicity, and intellectual ability; ASD prevalence 19.1% to 22.7% for black (in 2010 and 2014, respectively), was estimated both for children aged 4 years and 8 years 23.2% to 25.1% for Hispanic (in 2010 and 2014, respectively), living in the Early ADDM surveillance areas. Because the 4.7% to 5.0% for Asian/Pacific Islander (in 2014 and 2012, data for children aged 8 years are restricted to this smaller respectively), and 0.7% to 0.9% for American Indian/Alaska area, the estimates for those aged 8 years do not match those Native (in 2014 and 2010–2012, respectively), with similar previously published from the ADDM Network reports on percentages among children aged 8 years. ASD prevalence and characteristics (13–15). Trend analyses for ASD prevalence were restricted to the three sites (Arizona, Overall ASD Prevalence Missouri, and New Jersey) with data and consistent data Among Children Aged 4 Years sources for all 3 years; trends in the proportion of children Aggregating data across participating surveillance sites for with ASD who had co-occurring intellectual disabilities were each year, the estimated prevalence of ASD among children restricted to the two sites with data for all 3 years (Arizona aged 4 years was 13.4 per 1,000 in 2010, 15.3 in 2012, and and New Jersey). Cochran-Armitage trend tests were used to 17.0 in 2014 (Table 1). Prevalence ranged from 8.1 per 1,000 estimate the significance of changes in ASD characteristics children aged 4 years in Missouri (2012) to 28.4 in New Jersey over the 2010–2014 period. The nonparametric median (2014). For each year, aggregated ASD prevalence was higher test was used to determine differences in median age at first for study sites that reviewed education and health care records developmental evaluation and earliest known ASD diagnosis rather than health care records alone (Table 1); PRs for sites that from 2010 to 2014 and by sex and race/ethnicity within reviewed both types compared with only health care records surveillance years. PRs with CIs that did not include 1.00 were 1.8 (95% CI: 1.6–2.2) in 2010, 1.6 (95% CI: 1.4–1.8) were used to assess whether ASD prevalence was higher in in 2012, and 1.7 (95% CI: 1.5–2.0) in 2014 (data not shown). one population than another. For results from chi-square, Cochran-Armitage, and median tests, a p value of <0.05 was considered significant. Analyses were performed using SAS ASD Prevalence (version 9.4; SAS Institute). Among Children Aged 4 Years by Sex and Race/Ethnicity Across all sites and years, ASD prevalence per 1,000 boys Results aged 4 years ranged from 12.2 in Missouri (2010) to 44.0 Population Distribution in New Jersey (2014) (Table 2). Prevalence per 1,000 girls aged 4 years ranged from 3.2 in Missouri (2012) to 12.1 The overall Early ADDM Network geographic surveillance in New Jersey (2014). Male-to-female PRs indicated ASD area includes the seven sites that participated in at least one prevalence was higher among boys than girls in all sites and surveillance year (Figure 1). The Early ADDM Network years, ranging from 2.6 (Arizona and Wisconsin in 2010) to comprised a population from 58,467 (2010) to 70,887 (2014) 5.2 boys per one girl (Colorado in 2014). children aged 4 years and 56,727 (2010) to 71,928 (2014) Across all study sites and years for children aged 4 years, children aged 8 years (Supplemental Table 1, https://stacks. prevalence among white children ranged from 7.7 per 1,000 cdc.gov/view/cdc/76016). The distribution of children by in Missouri (2014) to 29.3 in New Jersey (2014) (Table 3). race/ethnicity varied across the sites. Among children aged Prevalence among black children ranged from 3.8 per 1,000 4 years, the percentage of white children ranged from 29.4% 8 MMWR / April 12, 2019 / Vol. 68 / No. 2 US Department of Health and Human Services/Centers for Disease Control and Prevention Surveillance Summaries in Missouri (2010) to 24.7 in New Jersey (2014). Prevalence ASD Diagnosis from a Community among Hispanic children ranged from 9.1 per 1,000 (in Provider Among Children Aged 4 Years Arizona (2010) to 28.2 in New Jersey (2014). In 2010, white The percentage of children with a documented ASD children had a higher ASD prevalence than Hispanic children in diagnosis from a community provider ranged from 43.0% Arizona (PR = 1.7) and black children in Missouri (PR = 2.5); in Arizona (2012) to 86.5% in Missouri (2012) but did not no other differences were observed by race/ethnicity. vary by sex (Table 6). The median age at first known ASD diagnosis ranged from 28 months in North Carolina (2014) Frequency of Co-Occurring to 39.0 months in Missouri and Wisconsin (2012). Among the Intellectual Disabilities three sites with data for all 3 surveillance years and consistent data sources, no significant trends were found in the proportion Among Children Aged 4 and 8 Years of children with an ASD diagnosis, overall or by sex Scores on intellectual ability tests were available for at least 60% of children in four sites for at least one surveillance year (Arizona, New Jersey, North Carolina, and Utah). These sites Trends in ASD Prevalence all reviewed education and health care records. In the two Among Children Aged 4 and 8 Years sites (Arizona and New Jersey) with data for all surveillance Four Early ADDM Network sites (Arizona, Missouri, New years, the percentage of children aged 4 years with ASD who Jersey, and Wisconsin) participated in all 3 surveillance years; had co-occurring intellectual disabilities was stable over time however, Wisconsin reviewed early intervention records in at 47.0%, 43.6%, and 46.0% in 2010, 2012, and 2014, 2014 but not earlier years, whereas data sources for other respectively (test for trend p value = 0.84) and also was stable sites were consistent across years. Among children aged over time among both boys and girls (Table 4). The proportion 4 years, ASD prevalence was higher in 2014 than in 2010 in of children with ASD who had co-occurring intellectual New Jersey (PR: 1.4) but not in Arizona or Missouri (Figure 2; disabilities was significantly higher among children aged 4 years Supplemental Table 4, https://stacks.cdc.gov/view/cdc/76016). than among those aged 8 years across all sites and surveillance In Wisconsin, ASD prevalence was higher in 2012 and 2014 years, with the exception of Arizona (2010) (Supplemental than in 2010. Among children aged 8 years living in the Early Table 2, https://stacks.cdc.gov/view/cdc/76016). ADDM Network geographical areas, ASD prevalence was higher in 2014 than in 2010 in New Jersey (PR: 1.3) but not Age at First Comprehensive in the other sites. In Missouri and Wisconsin, ASD prevalence was higher Developmental Evaluation among children aged 8 years than among those aged 4 years in Among Children Aged 4 Years all 3 years (Supplemental Table 4, https://stacks.cdc.gov/view/ Across all participating sites and surveillance years and cdc/76016). In Arizona, ASD prevalence was higher among among children born in the state where the ADDM Network children aged 8 years than among those aged 4 years in 2012 site was located, the percentage of children who received only, and in New Jersey, no differences by age were found. their first comprehensive developmental evaluation by age 36 months ranged from 48.8% (Missouri in 2012) to 88.9% ASD Prevalence Using DSM-IV-TR and (Wisconsin in 2014) (Table 5). Among the three sites with data and consistent data sources for all 3 years, patterns in the DSM-5 Case Definitions age at the first developmental evaluation varied by site. No A revised ADDM Network ASD surveillance case definition trend was observed in Arizona or Missouri. In New Jersey, was developed for the 2014 surveillance year to provide ASD from 2010 to 2014, the percentage of children who received a prevalence estimates based on the updated DSM-5 diagnostic first evaluation by age 36 months decreased significantly (from criteria published in 2013. All sites reviewed children’s 76.5% to 66.7%). In Wisconsin, the percentage of children records in the Early ADDM Network by both surveillance who received a first developmental evaluation by age 36 months case definitions to evaluate the effect on estimated prevalence was higher in 2014 (88.9%), when early intervention records because of the change to DSM-5 diagnostic criteria. Among were reviewed, than in 2010 and 2012 (69.0% and 73.4%, children aged 4 years in the Early ADDM Network in 2014, respectively). Percentages stratified by sex and race/ethnicity the prevalence of ASD using the DSM-5 surveillance case by site are provided (Supplemental Table 3, https://stacks.cdc. definition was 14.1 compared with 17.0 for DSM-IV-TR gov/view/cdc/76016). (DSM-IV-TR-to-DSM-5  PR:  1.2) (Table 7). Among US Department of Health and Human Services/Centers for Disease Control and Prevention MMWR / April 12, 2019 / Vol. 68 / No. 2 9 Surveillance Summaries FIGURE 2. Trends in autism spectrum disorder prevalence* among children aged 4 years and 8 years — Early Autism and Developmental Disabilities Monitoring Network, three sites, United States, 2010, 2012, and 2014 4 years 8 years 2010 2012 2014 2010 2012 2014 2010 2012 2014 Year Year Year Arizona Missouri New Jersey * In Arizona in 2012, the prevalence among children aged 4 years and children aged 8 years was significantly different (p<0.05 for chi-square test). In Missouri, the prevalence was significantly different in all 3 years. (In New Jersey, no differences were significant in any years.) 1,237 children who met the surveillance case definition for The overall prevalence estimate using a DSM-IV-TR case either DSM-IV-TR or DSM-5, 974 (78.7%) met both case definition was approximately 20% higher than the prevalence definitions, 234 (18.9%) met the DSM-IV-TR but not the estimate based on DSM-5 criteria. Meeting the DSM-5 DSM-5 case definition, and 29 (2.3%) met the DSM-5 but surveillance case definition required either documentation of not the DSM-IV-TR case definition. the more extensive behavioral criteria required for a DSM-5 diagnosis or an ASD diagnosis by a community provider, and preschool-aged children might have had fewer comprehensive evaluations containing behavioral information and been less Discussion likely to have a diagnosis. For the 2016 surveillance year, all This report provides data on ASD prevalence among children ADDM Network surveillance sites will use the DSM-5 case aged 4 years using ADDM surveillance methods across several definition, and trends in the prevalence of ASD among children sites participating in the Early ADDM Network during 2010, aged 4 years and 8 years will be monitored according to this 2012, and 2014. Among these children aged 4 years, overall surveillance case definition. estimated ASD prevalence was 13.4 per 1,000 in 2010, 15.3 in The estimated ASD prevalence in sites that reviewed both 2012, and 17.0 in 2014. ASD prevalence was higher among boys education and health care records was 60%–80% higher than than girls. Across all sites and surveillance years, few differences the estimated ASD prevalence among sites that reviewed in ASD prevalence were found by race/ethnicity among children only health care records. Although ASD prevalence varied aged 4 years, and those that were identified occurred in 2010 even among sites that reviewed education records, the total but not in later years. In the four sites that participated in Early prevalence among these sites (15.9, 17.4, and 19.3 per ADDM Network surveillance in all 3 years, ASD prevalence 1,000 children aged 4 years, respectively, for 2010–2014) is among children aged 4 years was approximately 40% higher likely a more sensitive estimate of ASD prevalence among in New Jersey in 2014 than in 2010 and similar across the children aged 4 years, suggesting that the overall estimated years in Arizona and Missouri. In Wisconsin, ASD prevalence ASD prevalence in the Early ADDM Network would have was significantly higher in 2014 than in 2010. However, the been higher had all sites had access to education records. availability of early intervention records in 2014 but not in Early intervention records also are an important source of earlier years might have influenced the prevalence estimates for information, particularly for tracking the age at earliest that year, even though prevalence was similar in 2012 when early evaluation. For example, the percentage of children evaluated intervention records were not reviewed. 10 MMWR / April 12, 2019 / Vol. 68 / No. 2 US Department of Health and Human Services/Centers for Disease Control and Prevention Prevalence per 1,000 children aged 4 or 8 years Surveillance Summaries by age 36 months in Wisconsin was higher when early In addition to the findings among preschool-aged children, intervention records were included for 2014 but not for earlier studies using different surveillance methods also have identified years. Together, these findings suggest that early intervention higher ASD prevalence among children in recent years and public education systems are a critical community resource (5–15,35). Several studies highlight changes in community for the evaluation of preschool-aged children who exhibit practice for recognizing and diagnosing ASD in children with social, communication, and behavioral impairments. Lack of developmental concerns, as well as expansion of the diagnostic access to early intervention and education records, combined criteria for ASD during 1987–2013 to include children with with indications from earlier reports (10–15) that many fewer or more mild symptoms, as factors contributing to the children with ASD are not evaluated until after age 4 years, higher prevalence (36–39). Although assessing whether ASD suggests that the estimate of ASD prevalence among children prevalence trends are, in part, associated with changes in aged 4 years might be an underestimate of the actual ASD etiologic risk is not possible with ADDM Network data, the prevalence in this birth cohort. heterogeneity of Early ADDM Network prevalence estimates across study sites, even among sites that reviewed both education and health care records, supports the hypothesis Other Studies of ASD Prevalence that differences in evaluation, diagnostic, and service practices Population-based data on the prevalence of ASD in affect measured prevalence. Previous data from the ADDM preschool-aged children are limited, and various case Network indicate a lower proportion of children with ASD ascertainment methods have been used; nevertheless, studies with co-occurring intellectual disabilities (10–15) over time, indicate that the prevalence of ASD in this age group has been consistent with improvements in the identification of children higher in recent years. In 1996, estimated ASD prevalence who have milder ASD. In addition, changes in the availability among children aged 4 years in MADDSP was 3.1 per 1,000 of services for children with ASD through insurance mandates (95% CI: 2.6–3.7), and the estimated prevalence per 1,000 (40), willingness of parents and providers to consider an ASD children aged 8 years was 4.7 (95% CI: 4.0–5.5) (16). A diagnosis, and greater awareness of and concern regarding ASD study using similar methods conducted in Brick Township, might contribute to the higher prevalence. New Jersey, reported an estimated ASD prevalence of 7.8 per 1,000 children aged 3–5 years (95% CI: 5.1–11.3) in Early Identification of and 1998 (30). A study from South Carolina in 2006 using MADDSP methods found an ASD prevalence of 8.0 per 1,000 Intervention for ASD children aged 4 years (31). A population-based study in the The American Academy of Pediatrics prioritized the early United Kingdom during 1998–1999 that used a multistage identification of ASD through its recommendation for screening and diagnosis methodology to identify children universal ASD screening during pediatric preventive care visits with PDD reported a prevalence estimate of 6.3 per 1,000 at ages 18 and 24 months (22) and by the U.S. Department children aged 3.5–6.5 years (32). Another study using the same of Health and Human Services through the Healthy People methods that was conducted several years later in a subsequent 2020 goal to increase the proportion of children with ASD who birth cohort reported a prevalence estimate of 5.9 per 1,000 receive their first evaluation by age 36 months. Evidence linking children aged 4–6 years (33). Approximately 10 years later, a early treatment for ASD with improved outcomes (18–21,41) report from the 2007 National Survey of Children’s Health implies that an absence or a delay in ASD identification could (NSCH) described estimated ASD prevalence by parent or delay interventions and initiation of special services. Identifying caregiver report to be 8.5 per 1,000 children aged 3–5 years the need for special services before school entry to minimize (95% CI: 6.0–12.0), compared with 13.2 per 1,000 children educational disruption and optimize educational outcomes aged 6–8 years (95% CI: 9.6–18.3) (6,34). Most recently, the might be especially important. 2016 NSCH reported ASD prevalence estimates of 19.7 per In this report, across all sites and surveillance years, the 1,000 children aged 3–5 years, 26.1 per 1,000 children aged median age at first known ASD evaluation among children 6–11 years, and 26.5 per 1,000 children aged 12–17 years aged 4 years with ASD ranged from 23 to 37 months, and (9). The most recent data from the National Health Interview 48.8% to 88.9% received their first ASD evaluation by age Survey showed a prevalence estimate (based on parent or 36 months. The percentage of children with an ASD diagnosis caregiver report) of 22.3 per 1,000 children aged 3–7 years in varied widely by study site, ranging from 43.0% to 86.5%, with 2016, which was lower than the prevalence estimate among sites that reviewed only health care records generally reporting children aged 8–12 years (28.8) (34). a greater percentage of children with an ASD diagnosis. This is not unexpected because other sites include children based US Department of Health and Human Services/Centers for Disease Control and Prevention MMWR / April 12, 2019 / Vol. 68 / No. 2 11 Surveillance Summaries wholly or partly on review of education records, which might Limitations not contain a formal ASD diagnosis. Among sites with data This report is subject to several limitations. First, because from all surveillance years and consistent data sources, the age these ASD prevalence estimates are based on a record review, at first evaluation was stable from 2010 to 2014 in Arizona and with no clinical examination, Early ADDM Network data Missouri. In New Jersey, the age at first evaluation increased reflect the information available in the source records. The from 2010 to 2014. The Wisconsin site gained access to records amount and quality of the data determine the potential for from early intervention services for children aged <3 years a child to meet the ASD surveillance case definition and the for the 2014 surveillance year, which likely contributed to extent to which they can be used to describe the characteristics detecting a greater number of children with a first evaluation of the identified population. Some children with ASD might by age 36 months. Age at first evaluation might be easier not have been included because their records were incomplete to lower than age at diagnosis because diagnosing ASD in or not available or they had not come to the attention of young children is challenging, which might be related to the schools or clinical providers, which might have resulted in an prodromal nature of autism’s phenotypic onset that has recently underestimate of the ASD prevalence. Second, the types of become apparent through longitudinal studies of infant siblings source records varied across surveillance sites, and the lack of at high risk for autism (42). However, greater awareness of availability of education or early intervention records at some ASD might result in more children being identified, including sites might have led to an underestimate of ASD prevalence those with symptoms that do not fully manifest until the among children aged 4 years in those sites and consequently for child is close to school age, increasing prevalence while also the Early ADDM Network overall. Third, early diagnoses of increasing the age of identification. Prevalence was higher ASD might change if another diagnosis is determined to better among children aged 8 years than among those aged 4 years in account for a child’s signs and symptoms (6,43,44), potentially some sites, which might reflect the identification of children affecting the specificity of records-based surveillance. However, with milder symptoms later in development or on school entry; the ADDM Network clinician review process allows clinicians this is supported by the difference in frequency of co-occurring to change the ASD surveillance case status, even if the child intellectual disabilities between children aged 4 and 8 years. has a previous ASD diagnosis, which helps decrease potential Efforts to identify developmental concerns as early as possible overestimates. Fourth, the availability of early intervention and decrease the age at first evaluation for all children with ASD records in Wisconsin for 2014 but not for earlier years are warranted. As recommended by the American Academy prevented the interpretation of changes in prevalence as well the of Pediatrics, universal screening might identify children age at earliest developmental evaluation and ASD diagnosis for who need a comprehensive evaluation for ASD, even in the that site. Fifth, measurement of intellectual ability in preschool- absence of previous developmental concerns or co-occurring aged children is less reliable than measurement among school- intellectual disabilities, and improved tools for discerning the aged children (26,27), preventing more specific classification signs of ASD among the range of typical childhood behaviors of intellectual ability among children with ASD other than might aid efforts to identify children earlier. Public health the presence or absence of intellectual disability. Sixth, data on campaigns such as Learn the Signs. Act Early. (https://www. intellectual ability were not available for all children, and the cdc.gov/ncbddd/actearly/index.html) provide informational distribution of intellectual ability among the children with these materials for parents, providers, and community members data might not be generalizable to all children with ASD in the aimed at improving awareness of developmental milestones Early ADDM Network if the data on intellectual ability are not and increasing early identification of developmental delays so randomly missing. For example, children without a cognitive that children can receive appropriate services and treatments test score might not have been tested because their intellectual as early as possible. ability was clearly in the average to above-average range, thus No significant trends were found in the percentage of overestimating the proportion of children with ASD and children with a documented ASD diagnosis or in the age at co-occurring intellectual disabilities. Seventh, the surveillance earliest known diagnosis. Children with an early evaluation sites were selected through a competitive process and were not can begin to receive behavioral and developmental services selected to be representative of children aged 4 years either in and interventions even if a formal ASD diagnosis is not made the United States or in the entire state in which surveillance at that time. However, a formal diagnosis might be necessary occurred. Therefore, the estimated prevalence of ASD is limited to receive certain ASD services; therefore, the 35%–40% of to the surveillance areas. Finally, analyses of trends were limited children who met the ASD surveillance case definition but did to three sites with data and consistent data sources for all 3 not have a documented ASD diagnosis might not be eligible surveillance years, and within sites, data were sparse for certain for services that depend on an ASD diagnosis. 12 MMWR / April 12, 2019 / Vol. 68 / No. 2 US Department of Health and Human Services/Centers for Disease Control and Prevention Surveillance Summaries race/ethnicity groups. In addition, patterns of ASD prevalence sites. However, variations in prevalence did not always align and characteristics varied by site; therefore, in some cases, data with access to data sources, and differences in evaluation and could not be combined, limiting the statistical power. diagnostic services among different areas might account for some differences in findings across surveillance sites. This suggests that opportunities for improvements in services might exist based on Estimating ASD Prevalence Using successful programs implemented in specific areas. Continuing Surveillance Data improvements in providing developmental evaluations to children Surveillance data from the Early ADDM Network provides as soon as developmental concerns are identified might result 1) population-based ascertainment of ASD using multiple in earlier ASD diagnoses and earlier receipt of services, which community data sources, including education and early might improve developmental outcomes. No treatment for ASD intervention records for some sites; 2) inclusion of children is available, although interventions might maximize each child’s with documentation of behaviors consistent with ASD but ability to function and participate in the community (18–21,41). without a documented ASD diagnosis; 3) data on intellectual Conflicts of Interest disability based on standardized tests of intellectual ability; and 4) collection of information on the age at first comprehensive Deborah Bilder reports personal fees from Audentes Therapeutics evaluation and ASD diagnosis, when present, that provide and personal fees from BioMarin Pharmaceuticals outside the submitted work. John Constantino receives royalties from Western information on early identification of children with ASD. The Psychological Services for the commercial distribution of the Social record review method allows population-based estimates of ASD Responsiveness Scale. prevalence to be generated cost-effectively. 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Rice CE, Baio J, Van Naarden Braun K, Doernberg N, Meaney FJ, org/10.1016/j.jaac.2012.08.018 Kirby RS; ADDM Network. A public health collaboration for the 42. Piven J, Elison JT, Zylka MJ. Toward a conceptual framework for surveillance of autism spectrum disorders. Paediatr Perinat Epidemiol early brain and behavior development in autism. Mol Psychiatry 2007;21:179–90. https://doi.org/10.1111/j.1365-3016.2007.00801.x 2017;22:1385–94. https://doi.org/10.1038/mp.2017.131 24. US Department of Health and Human Services. Code of Federal 43. Pringle B, Colpe LJ, Blumberg SJ, Avila RM, Kogan MD. Diagnostic Regulations. Title 45. Public Welfare CFR 46. Washington, DC: US history and treatment of school-aged children with autism spectrum Department of Health and Human Services; 2010. disorder and special health care needs. NCHS Data Brief 2012;97:1–8. 25. American Psychiatric Association. Diagnostic and statistical manual of 44. 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J Autism Dev Disord 2011;41:227–36. https://doi. org/10.1007/s10803-010-1050-7 14 MMWR / April 12, 2019 / Vol. 68 / No. 2 US Department of Health and Human Services/Centers for Disease Control and Prevention Surveillance Summaries Appendix Detailed Method for Estimating Surveillance Area Population Size of Partial Counties For 2010, the number of children aged 4 years by sex and race/ethnicity was obtained for each census tract in the county from the 2010 decennial census counts. Next, each census tract was matched to the school district or districts to which it was fully or partially allocated, using the MABLE/Geocorr12: Geographic Correspondence Engine provided by the Missouri Census Data Center (http://mcdc.missouri.edu). A list of excluded or partially excluded census tracts was compiled, and the number of children aged 4 years living in these census tracts was subtracted from the overall and sex- and race-specific total numbers of children in the county. For census tracts that were partially allocated to a school district, weighting was based on the 2010 census population of the county. Finally, population counts of children aged 4 years in each specific census race/ethnicity category (white, black, American Indian/Alaska Native, Asian/Pacific Islander, other race/ethnicity, multiracial, and Hispanic) were adjusted to the distribution of the National Center on Health Statistics (NCHS) bridged-race category counts for the county, thereby incorporating children categorized in the census counts as multiracial or other race into the bridged-race categories reported by NCHS (white, black, Hispanic, American Indian/Alaska Native, and Asian/Pacific Islander). The same methods were used to estimate the prevalence of ASD among children aged 8 years living in the Early ADDM Network surveillance area. For the nondecennial census years 2012 and 2014, denominators for sites that covered less than a full county were estimated by using school enrollment counts for the appropriate grades in the covered area and applying the distribution of these counts to the county-level bridged-race postcensal population estimates from NCHS (http://www.cdc.gov/nchs). US Department of Health and Human Services/Centers for Disease Control and Prevention MMWR / April 12, 2019 / Vol. 68 / No. 2 15 Surveillance Summaries TABLE 1. Prevalence* of autism spectrum disorder among children TABLE 2. Prevalence* of autism spectrum disorder among children aged 4 years — Autism and Developmental Disabilities Monitoring aged 4 years, by sex — Early Autism and Developmental Disabilities Network, seven sites, United States, 2010, 2012, and 2014 Monitoring Network, seven sites, United States, 2010, 2012, and 2014 Sex Year, record source, No. with Total and site ASD population Prevalence (95% CI) Male Female Year, Prevalence ratio, record source, Prevalence Prevalence male to female Health care and education † and site (95% CI) (95% CI) (95% CI) Arizona 123 9,265 13.3 (11.0–15.8) §,¶ New Jersey 352 17,860 19.7 (17.7–21.9) ¶, Health care and education Utah ** 132 10,944 12.1 (10.1–14.3) Arizona 18.9 (15.2–23.3) 7.3 (5.0–10.3) 2.6 (1.7–3.9) Total 607 38,069 15.9 (14.7–17.3) New Jersey 31.7 (28.1–35.5) 7.2 (5.5–9.2) 4.4 (3.3–5.8) Health care only †† Utah 17.9 (14.6–21.7) 5.9 (4.0–8.3) 3.1 (2.0–4.6) Missouri 103 12,095 8.5 (7.0–10.3) §§ Health care only Wisconsin 73 8,303 8.8 (6.9–11.1) Missouri 12.2 (9.6–15.3) 4.6 (3.0–6.7) 2.7 (1.7–4.1) Total 176 20,398 8.6 (7.4–10.0) Wisconsin 12.5 (9.4–16.4) 4.8 (2.9–7.4) 2.6 (1.6–4.4) Combined total 783 58,467 13.4 (12.5–14.4) Health care and education Health care and education Arizona 21.3 (17.5–25.8) 4.6 (2.8–7.0) 4.7 (2.9–7.5) Arizona 128 9,621 13.3 (11.1–15.8) New Jersey 33.6 (30.0–37.5) 9.9 (8.0–12.2) 3.4 (2.7–4.3) New Jersey 403 18,223 22.1 (20.0–24.4) Utah 20.7 (17.2–24.8) 5.7 (3.9–8.1) 3.6 (2.5–5.4) Utah 152 11,398 13.3 (11.3–15.6) Health care only Total 683 39,242 17.4 (16.1–18.8) Missouri 12.9 (10.2–16.2) 3.2 (1.9–5.0) 4.0 (2.4–6.7) Health care only Wisconsin 23.7 (19.4–28.8) 6.4 (4.2–9.4) 3.7 (2.4–5.7) Missouri 96 11,878 8.1 (6.5–9.9) Wisconsin 128 8,336 15.4 (12.8–18.3) Health care and education Total 224 20,214 11.1 (9.7–12.6) Arizona 21.3 (17.4–25.8) 5.2 (3.3–7.7) 4.1 (2.7–6.4) Combined total 907 59,456 15.3 (14.3–16.3) Colorado 22.3 (18.1–27.3) 4.3 (2.5–6.8) 5.2 (3.1–8.6) 2014 § New Jersey 44.0 (39.9–48.5) 12.1 (10.0–14.7) 3.6 (2.9–4.5) Health care and education North 24.7 (21.3–28.5) 5.8 (4.2–7.8) 4.2 (3.0–5.9) Arizona 130 9,624 13.5 (11.3–16.0) Carolina ¶¶ Colorado 113 8,438 13.4 (11.0–16.1) Health care only New Jersey 514 18,112 28.4 (26.0–30.9) Missouri 14.2 (11.3–17.5) 4.8 (3.2–7.0) 3.0 (1.9–4.6) ¶, North Carolina *** 231 14,893 15.5 (13.6–17.6) § Wisconsin 20.8 (16.7–25.6) 4.8 (2.9–7.6) 4.3 (2.6–7.1) Total 988 51,067 19.3 (18.2–20.6) Abbreviations: CI = confidence interval; PR = prevalence ratio. Health care only * Prevalence per 1,000 children age 4 years living in the surveillance areas Missouri 112 11,613 9.6 (7.9–11.6) according to the 2010 decennial bridged-race population estimates (US Census Wisconsin 108 8,207 13.2 (10.8–15.9) Bureau. Census summary file 1: Tables PCT12H–PCT12O. Washington, DC: Total 220 19,820 11.1 (9.7–12.7) US Census Bureau; 2010), the vintage 2014 postcensal bridged-race population Combined total 1,208 70,887 17.0 (16.1–18.0) estimates for 2012 (http://www.cdc.gov/nchs), and the vintage 2016 postcensal bridged-race population estimates for 2014 (http://www.cdc.gov/nchs). Abbreviations: ASD = autism spectrum disorder; CI = confidence interval. Results for PRs considered statistically significant when the CI excludes the * Prevalence per 1,000 children aged 4 years living in the surveillance areas null value (PR = 1.0). according to the 2010 decennial bridged-race population estimates Site also reviewed records from early intervention sources. (US Census Bureau. Census summary file 1: Tables PCT12H–PCT12O. Washington, DC: US Census Bureau; 2010), the vintage 2014 postcensal bridged-race population estimates for 2012 (http://www.cdc.gov/nchs), and the vintage 2016 postcensal bridged-race population estimates for 2014 (http://www.cdc.gov/nchs). Part of one county in metropolitan Phoenix for 2010, 2012, and 2014. Essex and Union counties for 2010, 2012, and 2014. Site also reviewed records from early intervention sources. ** Tooele County, part of Salt Lake County, for 2010 and 2012 only. †† One county in metropolitan St. Louis for 2010, 2012, and 2014. §§ Dane and Rock counties for 2010, 2012, and 2014. ¶¶ One county in metropolitan Denver for 2014 only. *** Alamance, Chatham, Guilford, Orange, and Forsyth counties for 2014 only. 16 MMWR / April 12, 2019 / Vol. 68 / No. 2 US Department of Health and Human Services/Centers for Disease Control and Prevention Surveillance Summaries TABLE 3. Prevalence* of autism spectrum disorder among children aged 4 years, by race/ethnicity — Early Autism and Developmental Disabilities Monitoring Network, seven sites, United States, 2010, 2012, and 2014 Prevalence (95% CI) Prevalence ratio (95% CI) Year, record source, and site White, non-Hispanic Black, non-Hispanic Hispanic White to black White to Hispanic Health care and education Arizona 15.7 (12.4–19.7) — 9.1 (6.2–12.9) — 1.7 (1.1–2.6) New Jersey 18.9 (15.5–22.7) 16.7 (13.6–20.4) 22.5 (18.6–27.0) 1.1 (0.9–1.5) 0.8 (0.6–1.1) Utah 14.0 (11.3–17.2) — 9.8 (6.7–13.8) — 1.4 (1.0–2.1) Health care only Missouri 9.3 (7.2–11.9) 3.8 (2.1–6.4) 14.4 (6.2–28.4) 2.5 (1.4–4.4) 0.6 (0.3–1.4) Wisconsin 8.2 (6.0–10.9) — — — — Health care and education Arizona 14.5 (11.4–18.1) 20.7 (8.3–42.7) 9.9 (6.8–13.8) 0.7 (0.3–1.5) 1.5 (1.0–2.2) New Jersey 24.2 (20.3–28.5) 19.3 (15.9–23.1) 22.3 (18.6–26.6) 1.3 (1.0–1.6) 1.1 (0.8–1.4) Utah 14.3 (11.5–17.5) — 11.3 (8.1–15.4) — 1.3 (0.9–1.8) Health care only Missouri 8.3 (6.3–10.8) 7.6 (5.1–11.0) — 1.1 (0.7–1.7) — Wisconsin 13.9 (11.0–17.2) 7.6 (3.0–15.6) 15.6 (9.1–24.9) 1.8 (0.8–4.0) 0.9 (0.5–1.5) Health care and education Arizona 15.2 (12.0–18.8) 14.9 (4.8–34.8) 11.1 (7.8–15.4) 1.0 (0.4–2.5) 1.4 (0.9–2.0) Colorado 11.7 (8.3–16.2) 18.0 (10.5–28.9) 12.3 (9.1–16.2) 0.7 (0.4–1.2) 1.0 (0.6–1.5) New Jersey 29.3 (24.8–34.2) 24.7 (20.9–29.0) 28.2 (24.1–32.8) 1.2 (0.9–1.5) 1.0 (0.8–1.3) North Carolina 14.6 (11.8–17.8) 16.8 (13.2–21.0) 10.9 (7.5–15.3) 0.9 (0.6–1.2) 1.3 (0.9–2.0) Health care only Missouri 7.7 (5.8–10.1) 10.4 (7.3–14.3) — 0.7 (0.5–1.1) — Wisconsin 13.1 (10.3–16.3) 9.7 (4.2–19.1) 11.5 (5.9–20.0) 1.3 (0.6–2.8) 1.1 (0.6–2.1) Abbreviations: CI = confidence interval; PR = prevalence ratio. * Prevalence per 1,000 children aged 4 years living in the surveillance areas according to the 2010 decennial bridged-race population estimates (US Census Bureau. Census summary file 1: Tables PCT12H–PCT12O. Washington, DC: US Census Bureau; 2010), the vintage 2014 postcensal bridged-race population estimates for 2012 (http://www.cdc.gov/nchs), and the vintage 2016 postcensal bridged-race population estimates for 2014 (http://www.cdc.gov/nchs). Results for PRs considered statistically significant when the CI excludes the null value (PR = 1.0). Site also reviewed records from early intervention sources. Estimates suppressed due to small cell sizes (N<5). TABLE 4. Number and percentage of children with co-occurring intellectual disability* among children aged 4 years with autism spectrum disorder, by site, sex, and year — Early Autism and Developmental Disabilities Monitoring Network, four sites, United States, 2010, 2012, and 2014 2010 2012 2014 2010–2014 Children Children Children Children Children Children with cognitive with co-occurring with cognitive with co-occurring with cognitive with co-occurring test scores intellectual disability test scores intellectual disability test scores intellectual disability No. No. No. Site and (% of children (% of children (% of children sex with ASD) No. (%) with ASD) No. (%) with ASD) No. (%) p value Site Arizona 105 (85.4) 43 (41.0) 80 (62.5) 33 (41.3) 90 (69.2) 45 (50.0) 0.21 New Jersey 291 (82.7) 143 (49.1) 337 (83.6) 149 (44.2) 418 (81.3) 189 (45.2) 0.34 North — — — — 142 (61.5) 64 (45.1) — Carolina Utah 97 (73.5) 40 (41.2) — — — — — Sex** Male 312 (82.3) 152 (48.7) 334 (79.1) 146 (43.7) 409 (79.9) 191 (46.7) 0.65 Female 84 (87.5) 34 (40.5) 83 (76.1) 36 (43.4) 99 (75.0) 43 (43.4) 0.69 Total** 396 (83.4) 186 (47.0) 417 (78.5) 182 (43.6) 508 (78.9) 234 (46.1) 0.84 Abbreviation: ASD = autism spectrum disorder. * Defined as a score of ≤70 on the most recent standardized cognitive ability test. Including sites for which at least 60% of children with ASD had cognitive ability test score data for at least 1 surveillance year. Cochran-Armitage trend test for percentage with intellectual disability; p<0.05 indicates statistical significance. No or insufficient data for site and surveillance year. ** Data restricted to sites with information for all 3 years (Arizona and New Jersey). US Department of Health and Human Services/Centers for Disease Control and Prevention MMWR / April 12, 2019 / Vol. 68 / No. 2 17 Surveillance Summaries TABLE 5. Median age at earliest known comprehensive evaluation and percentage of children evaluated by age 36 months among children aged 4 years with autism spectrum disorder — Early Autism and Developmental Disabilities Monitoring Network, seven sites, United States, 2010, 2012, and 2014 2010 2012 2014 No. (%) with No. (%) with No. (%) with Site and Median age Total no. evaluation Median age Total no. evaluation Median age Total no. evaluation record source (months) with ASD by 36 months (months) with ASD by 36 months (months) with ASD by 36 months p value* Health care and education Arizona 34.0 95 58 (61.1) 32.0 110 74 (67.3) 32.5 110 76 (69.1) 0.23 † † † † † † § Colorado — — — — — — 34.0 93 75 (80.6) — New Jersey 26.0 307 235 (76.5) 29.0 344 271 (78.8) 34.0 403 269 (66.7) 0.002 † † † † † † § North Carolina — — — — — — 23.0 198 164 (82.8) — † † † § Utah 32.0 107 75 (70.1) 32.0 115 72 (62.6) — — — — Health care only Missouri 30.0 88 61 (69.3) 37.0 80 39 (48.8) 29.0 90 67 (74.4) 0.46 Wisconsin 27.5 58 40 (69.0) 29.0 109 80 (73.4) 24.0 90 80 (88.9) — Abbreviation: ASD = autism spectrum disorder. * Cochran-Armitage trend test for proportion with evaluation by age 36 months; p<0.05 indicates statistical significance. No data for site and surveillance year. Trend not estimated for sites with <3 years of data. Trend not estimated because records were included from early intervention sources for 2014 but not earlier years. TABLE 6. Number and percentage of children aged 4 years with a previous autism spectrum disorder diagnosis and median age at earliest known diagnosis — Early Autism and Developmental Disabilities Monitoring Network, seven sites, United States, 2010, 2012, and 2014 2010 2012 2014 2010–2014 Median age Median age Median age (months) (months) (months) No. (%) of earliest No. (%) of earliest No. (%) of earliest with any known with any known with any known Site and Total no. ASD ASD Total no. ASD ASD Total no. ASD ASD record source with ASD diagnosis diagnosis with ASD diagnosis diagnosis with ASD diagnosis diagnosis p value* Health care and education Arizona 123 53 (43.1) 35.0 128 55 (43.0) 36.0 130 56 (43.1) 36.0 1.0 † † † † † † § Colorado — — — — — — 113 72 (63.7) 31.0 — New Jersey 352 207 (58.8) 32.5 403 236 (58.6) 35.0 514 292 (56.8) 33.5 0.54 † † † † † † § North Carolina — — — — — — 231 107 (46.3) 28.0 — † † † § Utah 132 106 (80.3) 35.0 152 122 (80.3) 35.0 — — — — Health care only Missouri 103 84 (81.6) 34.0 96 83 (86.5) 39.0 112 96 (85.7) 36.0 0.41 Wisconsin 73 61 (83.6) 34.0 128 93 (72.7) 39.0 108 77 (71.3) 33.0 — Abbreviation: ASD = autism spectrum disorder. * Cochran-Armitage trend test for percentage with any ASD diagnosis; p<0.05 indicates statistical significance. No data for site for surveillance year. Trend not estimated for sites with <3 years of data. Trend not estimated because records were included from early intervention sources for 2014 but not earlier years. 18 MMWR / April 12, 2019 / Vol. 68 / No. 2 US Department of Health and Human Services/Centers for Disease Control and Prevention Surveillance Summaries TABLE 7. Number and prevalence* of children aged 4 years meeting DSM-IV-TR or DSM-5 autism spectrum disorder case definition — Autism and Developmental Disabilities Monitoring Network, seven sites, United States, 2014 DSM-IV-TR DSM-5 Prevalence ratio (95% CI), Site and record source No. Prevalence (95% CI) No. Prevalence (95% CI) DSM-IV-TR to DSM-5 Health care and education Arizona 130 13.5 (11.3–16.0) 102 10.6 (8.6–12.9) 1.3 (1.0–1.7) Colorado 113 13.4 (11.0–16.1) 93 11.0 (8.9–13.5) 1.2 (0.9–1.6) New Jersey 514 28.4 (26.0–30.9) 406 22.4 (20.3–24.7) 1.3 (1.1–1.4) North Carolina 231 15.5 (13.6–17.6) 204 13.7 (11.9–15.7) 1.1 (0.9–1.4) Health care only Missouri 112 9.6 (7.9–11.6) 105 9.0 (7.4–10.9) 1.1 (0.8–1.4) Wisconsin 108 13.2 (10.8–15.9) 93 11.3 (9.1–13.9) 1.2 (0.9–1.5) Total 1,208 17.0 (16.1–18.0) 1,003 14.1 (13.3–15.1) 1.2 (1.1–1.3) Abbreviations: CI = confidence interval; DSM-IV-TR = Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision; DSM-5 = Diagnostic and Statistical Manual of Mental Disorder, Fifth Edition. * Prevalence per 1,000 children aged 4 years living in the surveillance areas according to the vintage 2016 postcensal bridged-race population estimates for 2014 (http://www.cdc.gov/nchs). Results for PRs considered statistically significant when the CI excludes the null value (PR = 1.0). Site also reviewed records from early intervention sources. US Department of Health and Human Services/Centers for Disease Control and Prevention MMWR / April 12, 2019 / Vol. 68 / No. 2 19 The Morbidity and Mortality Weekly Report (MMWR) Series is prepared by the Centers for Disease Control and Prevention (CDC) and is available free of charge in electronic format. To receive an electronic copy each week, visit MMWR at https://www.cdc.gov/mmwr/index.html. Readers who have difficulty accessing this PDF file may access the HTML file at https://www.cdc.gov/mmwr/volumes/68/ss/ss6802a1.htm?s_ cid=ss6802a1_w. Address all inquiries about the MMWR Series, including material to be considered for publication, to Executive Editor, MMWR Series, Mailstop E-90, CDC, 1600 Clifton Rd., N.E., Atlanta, GA 30329-4027 or to mmwrq@cdc.gov. All material in the MMWR Series is in the public domain and may be used and reprinted without permission; citation as to source, however, is appreciated. MMWR and Morbidity and Mortality Weekly Report are service marks of the U.S. Department of Health and Human Services. Use of trade names and commercial sources is for identification only and does not imply endorsement by the U.S. Department of Health and Human Services. References to non-CDC sites on the Internet are provided as a service to MMWR readers and do not constitute or imply endorsement of these organizations or their programs by CDC or the U.S. Department of Health and Human Services. CDC is not responsible for the content of these sites. URL addresses listed in MMWR were current as of the date of publication. ISSN: 0149-2195 (Print) http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png MMWR Surveillance Summaries Pubmed Central

Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 4 Years — Early Autism and Developmental Disabilities Monitoring Networ ...

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Abstract

Morbidity and Mortality Weekly Report Surveillance Summaries / Vol. 68 / No. 2 April 12, 2019 Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 4 Years — Early Autism and Developmental Disabilities Monitoring Network, Seven Sites, United States, 2010, 2012, and 2014 U.S. Department of Health and Human Services Centers for Disease Control and Prevention Surveillance Summaries CONTENTS Introduction ............................................................................................................ 2 Methods .................................................................................................................... 3 Results ....................................................................................................................... 8 Discussion ............................................................................................................. 10 Limitations ............................................................................................................ 12 Conclusion ............................................................................................................ 13 References ............................................................................................................. 13 Appendix ............................................................................................................... 15 The MMWR series of publications is published by the Center for Surveillance, Epidemiology, and Laboratory Services, Centers for Disease Control and Prevention (CDC), U.S. Department of Health and Human Services, Atlanta, GA 30329-4027. Suggested citation: [Author names; first three, then et al., if more than six.] [Title]. MMWR Surveill Summ 2019;68(No. SS-#):[inclusive page numbers]. Centers for Disease Control and Prevention Robert R. Redfield, MD, Director Anne Schuchat, MD, Principal Deputy Director Chesley L. Richards, MD, MPH, Deputy Director for Public Health Science and Surveillance Rebecca Bunnell, PhD, MEd, Director, Office of Science Barbara Ellis, PhD, MS, Acting Director, Office of Science Quality, Office of Science Michael F. Iademarco, MD, MPH, Director, Center for Surveillance, Epidemiology, and Laboratory Services MMWR Editorial and Production Staff (Serials) Charlotte K. Kent, PhD, MPH, Editor in Chief Martha F. Boyd, Lead Visual Information Specialist Christine G. Casey, MD, Editor Maureen A. Leahy, Julia C. Martinroe, Mary Dott, MD, MPH, Online Editor Stephen R. Spriggs, Tong Yang, Teresa F. Rutledge, Managing Editor Visual Information Specialists David C. Johnson, Lead Technical Writer-Editor Quang M. Doan, MBA, Phyllis H. King, Catherine B. Lansdowne, MS, Project Editor Terraye M. Starr, Moua Yang, Information Technology Specialists MMWR Editorial Board Timothy F. Jones, MD, Chairman Matthew L. Boulton, MD, MPH Robin Ikeda, MD, MPH Stephen C. Redd, MD Virginia A. Caine, MD Phyllis Meadows, PhD, MSN, RN Patrick L. Remington, MD, MPH Katherine Lyon Daniel, PhD Jewel Mullen, MD, MPH, MPA Carlos Roig, MS, MA Jonathan E. Fielding, MD, MPH, MBA Jeff Niederdeppe, PhD William Schaffner, MD David W. Fleming, MD Patricia Quinlisk, MD, MPH Morgan Bobb Swanson, BS William E. Halperin, MD, DrPH, MPH Surveillance Summaries Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 4 Years — Early Autism and Developmental Disabilities Monitoring Network, Seven Sites, United States, 2010, 2012, and 2014 1 1 2 3 4 Deborah L. Christensen, PhD ; Matthew J. Maenner, PhD ; Deborah Bilder, MD ; John N. Constantino, MD ; Julie Daniels, PhD ; 5 3 6 6 7 Maureen S. Durkin, PhD ; Robert T. Fitzgerald, PhD ; Margaret Kurzius-Spencer, PhD ; Sydney D. Pettygrove, PhD ; Cordelia Robinson, PhD ; 8 9 8 1 1 Josephine Shenouda, MS ; Tiffany White, PhD ; Walter Zahorodny, PhD ; Karen Pazol, PhD ; Patricia Dietz, DrPH Division of Congenital and Developmental Disorders, National Center on Birth Defects and Developmental Disabilities, CDC University of Utah, Salt Lake City Washington University in St. Louis, Missouri University of North Carolina, Chapel Hill University of Wisconsin, Madison University of Arizona, Tucson University of Colorado School of Medicine, Aurora Rutgers New Jersey Medical School, Newark Colorado Department of Public Health and Environment, Denver Abstract Problem/Condition: Autism spectrum disorder (ASD) is estimated to affect up to 3% of children in the United States. Public health surveillance for ASD among children aged 4 years provides information about trends in prevalence, characteristics of children with ASD, and progress made toward decreasing the age of identification of ASD so that evidence-based interventions can begin as early as possible. Period Covered: 2010, 2012, and 2014. Description of System: The Early Autism and Developmental Disabilities Monitoring (Early ADDM) Network is an active surveillance system that provides biennial estimates of the prevalence and characteristics of ASD among children aged 4 years whose parents or guardians lived within designated sites. During surveillance years 2010, 2012, or 2014, data were collected in seven sites: Arizona, Colorado, Missouri, New Jersey, North Carolina, Utah, and Wisconsin. The Early ADDM Network is a subset of the broader ADDM Network (which included 13 total sites over the same period) that has been conducting ASD surveillance among children aged 8 years since 2000. Each Early ADDM site covers a smaller geographic area than the broader ADDM Network. Early ADDM ASD surveillance is conducted in two phases using the same methods and project staff members as the ADDM Network. The first phase consists of reviewing and abstracting data from children’s records, including comprehensive evaluations performed by community professionals. Sources for these evaluations include general pediatric health clinics and specialized programs for children with developmental disabilities. In addition, special education records (for children aged ≥3 years) were reviewed for Arizona, Colorado, New Jersey, North Carolina, and Utah, and early intervention records (for children aged 0 to <3 years) were reviewed for New Jersey, North Carolina, Utah, and Wisconsin; in Wisconsin, early intervention records were reviewed for 2014 only. The second phase involves a review of the abstracted evaluations by trained clinicians using a standardized case definition and method. A child is considered to meet the surveillance case definition for ASD if one or more comprehensive evaluations of that child completed by a qualified professional describes behaviors consistent with the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision (DSM-IV-TR) diagnostic criteria for any of the following conditions: autistic disorder, pervasive developmental disorder–not otherwise specified (PDD-NOS, including atypical autism), or Asperger disorder (2010, 2012, and 2014). For 2014 only, prevalence estimates based on surveillance case definitions according to DSM-IV-TR and the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) were compared. This report provides estimates of overall ASD prevalence and prevalence by sex and race/ethnicity; characteristics of children aged 4 years with ASD, including age at first developmental evaluation, age at ASD diagnosis, and cognitive function; and trends in ASD prevalence and characteristics among Early ADDM sites with data for all 3 surveillance years (2010, 2012, and 2014), including comparisons with children aged 8 years living in the same geographic area. Analyses of time trends in ASD prevalence are restricted to the three sites that contributed data for all 3 surveillance years with consistent data sources (Arizona, Missouri, and New Jersey). US Department of Health and Human Services/Centers for Disease Control and Prevention MMWR / April 12, 2019 / Vol. 68 / No. 2 1 Surveillance Summaries Results: The overall ASD prevalence was 13.4 per 1,000 children aged 4 years in 2010, 15.3 in 2012, and 17.0 in 2014 for Early ADDM sites with data for the specific years. ASD prevalence was determined using a surveillance case definition based on DSM-IV-TR. Within each surveillance year, ASD prevalence among children aged 4 years varied across surveillance sites and was lowest each year for Missouri (8.5, 8.1, and 9.6 per 1,000, for 2010, 2012, and 2014, respectively) and highest each year for New Jersey (19.7, 22.1, and 28.4 per 1,000, for the same years, respectively). Aggregated prevalence estimates were higher for sites that reviewed education and health care records than for sites that reviewed only health care records. Among all participating sites and years, ASD prevalence among children aged 4 years was consistently higher among boys than girls; prevalence ratios ranged from 2.6 (Arizona and Wisconsin in 2010) to 5.2 boys per one girl (Colorado in 2014). In 2010, ASD prevalence was higher among non-Hispanic white children than among Hispanic children in Arizona and non-Hispanic black children in Missouri; no other differences were observed by race/ethnicity. Among four sites with ≥60% data on cognitive test scores (Arizona, New Jersey, North Carolina, and Utah), the frequency of co-occurring intellectual disabilities was significantly higher among children aged 4 years than among those aged 8 years for each site in each surveillance year except Arizona in 2010. The percentage of children with ASD who had a first evaluation by age 36 months ranged from 48.8% in Missouri in 2012 to 88.9% in Wisconsin in 2014. The percentage of children with a previous ASD diagnosis from a community provider varied by site, ranging from 43.0% for Arizona in 2012 to 86.5% for Missouri in 2012. The median age at earliest known ASD diagnosis varied from 28 months in North Carolina in 2014 to 39.0 months in Missouri and Wisconsin in 2012. In 2014, the ASD prevalence based on the DSM-IV-TR case definition was 20% higher than the prevalence based on the DSM-5 (17.0 versus 14.1 per 1,000, respectively). Trends in ASD prevalence and characteristics among children aged 4 years during the study period were assessed for the three sites with data for all 3 years and consistent data sources (Arizona, Missouri, and New Jersey) using the DSM-IV-TR case definition; prevalence was higher in 2014 than in 2010 among children aged 4 years in New Jersey and was stable in Arizona and Missouri. In Missouri, ASD prevalence was higher among children aged 8 years than among children aged 4 years. The percentage of children with ASD who had a comprehensive evaluation by age 36 months was stable in Arizona and Missouri and decreased in New Jersey. In the three sites, no change occurred in the age at earliest known ASD diagnosis during 2010–2014. Interpretation: The findings suggest that ASD prevalence among children aged 4 years was higher in 2014 than in 2010 in one site and remained stable in others. Among children with ASD, the frequency of cognitive impairment was higher among children aged 4 years than among those aged 8 years and suggests that surveillance at age 4 years might more often include children with more severe symptoms or those with co-occurring conditions such as intellectual disability. In the sites with data for all years and consistent data sources, no change in the age at earliest known ASD diagnosis was found, and children received their first developmental evaluation at the same or a later age in 2014 compared with 2010. Delays in the initiation of a first developmental evaluation might adversely affect children by delaying access to treatment and special services that can improve outcomes for children with ASD. Public Health Action: Efforts to increase awareness of ASD and improve the identification of ASD by community providers can facilitate early diagnosis of children with ASD. Heterogeneity of results across sites suggests that community-level differences in evaluation and diagnostic services as well as access to data sources might affect estimates of ASD prevalence and age of identification. Continuing improvements in providing developmental evaluations to children as soon as developmental concerns are identified might result in earlier ASD diagnoses and earlier receipt of services, which might improve developmental outcomes. Introduction Autism spectrum disorder (ASD) is a developmental determined to be at age 8 years. Therefore, subsequent to that disability marked by social and communication impairments, report, CDC has reported ASD prevalence among children as well as restricted interests and repetitive behaviors (1). ASD aged 8 years based on data collected every 2 years from 2000 prevalence has been measured by special education and other through 2014. Surveillance was conducted by MADDSP and administrative records (2–4), national surveys (5–9), and active other sites across the United States that participated in the public health surveillance conducted through the Metropolitan ADDM Network. The most recent ASD prevalence estimate Atlanta Developmental Disabilities Surveillance Program from the ADDM Network was 16.8 per 1,000 children aged (MADDSP) and its extended surveillance network, the 8 years in 2014 (13), compared with 14.5 per 1,000 in 2012 Autism and Developmental Disabilities Monitoring (ADDM) (14) and 14.7 per 1,000 in 2010 (15). Network (10–17). ASD prevalence was first measured by CDC Measuring ASD prevalence and age at diagnosis in elementary among children aged 3–10 years children by MADDSP in school–aged children is expected to yield the most complete 1996 (16). In that analysis, the peak prevalence of ASD was information on ASD prevalence and characteristics (13–15); 2 MMWR / April 12, 2019 / Vol. 68 / No. 2 US Department of Health and Human Services/Centers for Disease Control and Prevention Surveillance Summaries however, measuring ASD prevalence in preschool-aged children seven of these sites also conducted ASD surveillance and provides more timely assessment of efforts to increase awareness reported data for children aged 4 years for at least 1 year. The and early detection of ASD. Evidence linking early treatment Early ADDM Network included areas of Arizona, Colorado, for ASD with improved outcomes (18–21) implies that an Missouri, New Jersey, North Carolina, Utah, and Wisconsin absence or delay in ASD identification could adversely affect (Figure 1). Five Early ADDM sites participated in 2010 and children by delaying interventions and initiation of special 2012, and six sites participated in 2014. Three Early ADDM services. The American Academy of Pediatrics supports early sites (Arizona, Missouri, and New Jersey) contributed data and identification in their recommendation that all children receive had consistent data sources in all 3 surveillance years. ASD screening at ages 18 and 24 months (22). Each state has Because of resource constraints, Early ADDM surveillance programs to identify children with disabilities and provide was not conducted for the total geographic area covered by special services from birth through age 2 years; children at each study site’s ADDM surveillance for children aged 8 years; risk for or with disabilities are eligible for early intervention rather, each Early ADDM Network surveillance area was a services through part C of the Individuals with Disabilities subset of the site’s total ADDM surveillance area. Each Early Education Act (IDEA) (http://idea.ed.gov). Children aged ADDM surveillance area included at least 8,000 children ≥3 years with disabilities are eligible for evaluation and special aged 4 years and a similar number of children aged 8 years. In education services through part B of IDEA, and these services comparison, the total ADDM surveillance areas for children are provided by public school systems (http://idea.ed.gov). aged 8 years for each site included 9,767–51,161 children. The This report describes ASD prevalence estimates and Early ADDM surveillance areas were not random subsets of the characteristics among children aged 4 years in the Early total surveillance areas for the respective sites but were selected ADDM Network for 2010, 2012, and 2014. Selected trend to form areas of full counties or school districts, within the total analyses also are presented. The findings in this report can ADDM surveillance area that met or exceeded the minimum be used by pediatric health care providers, early intervention population size of 8,000 children aged 4 years. Therefore, service providers, therapists, school psychologists, educators, prevalence estimates for children aged 4 years generated by researchers, policymakers, and program administrators seeking the Early ADDM Network should not be interpreted as being to understand and provide for the needs of persons with ASD representative of the prevalence among children aged 4 years and their families. These data can be used to help plan for for the total ADDM study area at a given site. service needs and initiate and implement policies that promote Children included in this analysis were born in 2006, 2008, early identification of children with ASD. or 2010 for the surveillance years 2010, 2012, and 2014, respectively, and had a parent or guardian who lived in the Early ADDM Network surveillance area during all or part of the specific surveillance year. Participating Early ADDM sites were Methods selected through a competitive review process and were not To estimate the prevalence of ASD in a younger age group, selected to be nationally representative. A diverse population seven of the 13 ADDM sites that conducted ASD surveillance was preferred during the review process. Each ADDM site among children aged 8 years during 2010, 2012, 2014 (or all functioned as a public health authority under HIPAA (the these years) also collected ASD surveillance data for children Health Insurance Portability and Accountability Act of 1996) aged 4 years. These sites are collectively known as the Early and met applicable local Institutional Review Board, privacy, ADDM Network. The data for children aged 4 years were and confidentiality requirements (24). collected in subsets of the ADDM geographic areas for children aged 8 years. Case Ascertainment ADDM is an active surveillance system that does not Study Sites depend on family or professional reporting of an existing ASD The ADDM Network uses a multisite, multiple-source, diagnosis or classification to determine ASD case status. Case records-based surveillance method based on a model developed determination is a two-phase process. The first phase involves by CDC’s MADDSP (16,23). In 2010, 2012, and 2014, a total review and abstraction of records at multiple data sources in of 13 sites contributed data to the ADDM Network of ASD the community. In the second phase, all abstracted evaluations surveillance among children aged 8 years for at least 1 year are compiled and reviewed by trained study personnel to (Alabama, Arizona, Arkansas, Colorado, Georgia, Maryland, determine ASD case status. Data sources are categorized as Minnesota, Missouri, New Jersey, North Carolina, Tennessee, either 1) education source type, including evaluations to Utah, and Wisconsin). As part of the Early ADDM Network, US Department of Health and Human Services/Centers for Disease Control and Prevention MMWR / April 12, 2019 / Vol. 68 / No. 2 3 Surveillance Summaries FIGURE 1. Early Autism and Developmental Disabilities Monitoring Network surveillance areas — seven sites, United States, 2010, 2012, and 2014 determine eligibility for special education services or 2) health (ICD-10) billing codes for select childhood disabilities or care source type, including diagnostic and developmental conditions. Children’s records are screened to confirm year evaluations. Evaluations must have been performed by a of birth and residency in the surveillance area at some time qualified professional, such as a psychologist, physician, during the surveillance year. For children meeting age and physical therapist, occupational therapist, speech or language residency requirements, the source files are screened for certain pathologist, or educator. Children’s records are screened from behavioral or diagnostic descriptions defined by ADDM as multiple data sources to determine eligibility for inclusion as a triggers for abstraction (e.g., child does not initiate interactions potential case. Developmental assessments completed by a wide with others, prefers to play alone or engage in solitary range of health care and education providers are reviewed. All activities, or has received a documented ASD diagnosis). If Early ADDM Network sites had agreements in place to access abstraction triggers are found, evaluation information from records at health care sources. Special education records (for birth through the current surveillance year is abstracted into a children aged ≥3 years) were reviewed in Arizona, Colorado, single composite record for each child. The composite record New Jersey, North Carolina, and Utah, and early intervention includes comprehensive evaluations by qualified professionals records (for children aged 0 to <3 years) were reviewed in New from birth through the end of the year when the child reaches Jersey, North Carolina, Utah, and Wisconsin; in Wisconsin, either age 4 or 8 years. early intervention records were reviewed for 2014 only. The In the second phase of surveillance, the abstracted ADDM Network review only includes existing records, not comprehensive evaluations are deidentified and reviewed clinical examinations of children. systematically by clinicians who have undergone standardized In the first phase of surveillance, ADDM Network sites training to determine ASD case status using a coding scheme identify source records to review according to a child’s year of based on the Diagnostic and Statistical Manual of Mental birth and either 1) eligibility classifications in special education Disorders, 4th Edition, Text Revision (DSM-IV-TR) (25) or early intervention, or 2) International Classification of criteria for ASD. These clinicians review each comprehensive Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) evaluation and code the behavioral descriptors according to or International Classification of Diseases, Tenth Revision the DSM-IV-TR criteria represented by the descriptor. 4 MMWR / April 12, 2019 / Vol. 68 / No. 2 US Department of Health and Human Services/Centers for Disease Control and Prevention Surveillance Summaries Surveillance Case Definition Descriptive Characteristics Children included in this analysis were born in 2006, 2008, or Demographic information, including sex and race/ethnicity, 2010 for the surveillance years 2010, 2012, and 2014, respectively, was abstracted. Data on sex were available for all children. and had a parent or guardian who lived in the Early ADDM Data on race/ethnicity were missing for <5% of children Network surveillance area during all or part of the specific across all years, age groups, and surveillance sites. Children surveillance year. A child aged 4 or 8 years met the surveillance with missing race/ethnicity data were not included in analyses case definition for ASD if behaviors described within one or more stratified by race/ethnicity but were included in analyses of all comprehensive evaluations were consistent with the DSM-IV-TR children combined. Each site obtained vital records data for the diagnostic criteria for any of the following conditions: autistic relevant birth year, which were linked to surveillance data to disorder, pervasive developmental disorder–not otherwise specified obtain supplemental information on race/ethnicity and other (PDD-NOS, including atypical autism), or Asperger disorder demographic characteristics. (Box 1). An ASD diagnosis alone was not sufficient to meet the Diagnostic summaries from each evaluation were abstracted DSM-IV-TR surveillance case definition but was considered for each child, including notation of any ASD diagnosis by during the clinician review process, along with behavioral subtype. Children were considered to have an ASD diagnosis criteria. Most records were reviewed by a single person, from a community provider if they received a diagnosis of although clinicians were able to request a second review if they autistic disorder, Asperger disorder, PDD-NOS, or ASD that were uncertain about whether the behaviors were consistent was documented in an abstracted evaluation at any time from with the DSM-IV-TR diagnostic criteria. Children could have birth through the year when they reached age 4 or 8 years. The been disqualified from meeting the case definition if their age at each documented ASD diagnosis from a community behaviors met the surveillance case definition but one or more provider was abstracted, as well as the age at each comprehensive clinician reviewers judged that sufficient information existed to developmental evaluation. These data were used to determine rule out ASD, information to support an ASD diagnosis was the age at the earliest known ASD diagnosis, if any, and the conflicting or insufficient, or that one or more other diagnosed age at the first comprehensive developmental evaluation. Data conditions better accounted for their symptoms. on age at first evaluation were restricted to children who were Updated behavioral criteria for an ASD diagnosis were born in the state where the ADDM Network site was located published in 2013 in the Diagnostic and Statistical Manual to avoid bias from the inability to locate early evaluations for of Mental Disorders, 5th Edition (DSM-5) (1). To determine children who moved into the study area. In-state birth was the effect of the updated DSM-5 behavioral criteria on ASD determined through a successful match to a birth certificate prevalence, a revised surveillance case definition (Box 2) also from that state. If no birth certificate was found, the child was used to classify cases for the 2014 surveillance year. A child was presumed to have been born outside the state where the aged 4 or 8 years met the DSM-5 surveillance case definition if surveillance site was located. Because all children had at least behaviors described within one or more comprehensive evaluations one evaluation, the age at the first evaluation was available for were consistent with the DSM-5 diagnostic criteria or if an all children and is reported as the median age (in months), ASD diagnosis had been documented, regardless of whether the along with the percentage of children with a first evaluation by behavioral criteria had been met. Most records were reviewed by age 36 months. This age was chosen to align with the Healthy a single person, although clinicians were able to request a second People 2020 (http://www.healthypeople.gov/2020/default. review if they were uncertain about whether the behaviors were aspx) goal of increasing the percentage of children with ASD consistent with the DSM-5 diagnostic criteria. Children could who receive their first developmental evaluation by the age of have been disqualified from meeting the case definition if their 36 months. Not all children had a documented ASD diagnosis behaviors met the surveillance case definition but one or more from a community provider; a total of 272 (34.7%), 318 clinician reviewers judged that sufficient information existed to (35.1%), and 508 (42.1%) children had no ASD diagnosis for rule out ASD, information to support an ASD diagnosis was 2010, 2012, and 2014, respectively. The age at earliest known conflicting or insufficient, or that one or more other diagnosed ASD diagnosis could be described only for those children with conditions better accounted for their symptoms. a documented diagnosis and is reported as the median age in In this report, most results are based on the DSM-IV-TR months. Ages of <6 months at earliest known ASD diagnosis surveillance case definition for consistency and comparison were excluded for implausibility (n = 2). across surveillance years. Results comparing ASD prevalence Data were collected on results of standardized tests of using both DSM-IV-TR and DSM-5 surveillance case intellectual ability found in children’s records, and children definitions are included for 2014. were considered to have an intellectual disability if they had US Department of Health and Human Services/Centers for Disease Control and Prevention MMWR / April 12, 2019 / Vol. 68 / No. 2 5 Surveillance Summaries BOX 1. Surveillance case definition based on behavioral criteria for diagnosis of autism spectrum disorder: Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision DSM-IV-TR behavioral criteria Social 1a. Marked impairment in the use of multiple nonverbal behaviors, such as eye-to-eye gaze, facial expression, body postures, and gestures to regulate social interaction 1b. Failure to develop peer relationships appropriate to developmental level 1c. A lack of spontaneous seeking to share enjoyment, interests, or achievements with other people (e.g., by a lack of showing, bringing, or pointing out objects of interest) 1d. Lack of social or emotional reciprocity Communication 2a. Delay in, or total lack of, the development of spoken language (not accompanied by an attempt to compensate through alternative modes of communication, such as gesture or mime) 2b. In individuals with adequate speech, marked impairment in the ability to initiate or sustain a conversation with others 2c. Stereotyped and repetitive use of language or idiosyncratic language 2d. Lack of varied, spontaneous make-believe play or social imitative play appropriate to developmental level Restricted behavior/Interest 3a. Encompassing preoccupation with one or more stereotyped and restricted patterns of interest that is abnormal either in intensity or focus 3b. Apparently inflexible adherence to specific, nonfunctional routines, or rituals 3c. Stereotyped and repetitive motor mannerisms (e.g., hand or finger flapping or twisting, or complex whole body movements) 3d. Persistent preoccupation with parts of objects Developmental history Child had identified delays or any concern with development in the following areas at or before the age of 3 years: Social, Communication, Behavior, Play, Motor, Attention, Adaptive, or Cognitive Autism discriminators Oblivious to children Oblivious to adults or others Rarely responds to familiar social approach Language primarily echolalia or jargon Regression/loss of social, language, or play skills Previous ASD diagnosis, whether based on DSM-IV-TR or DSM-5 diagnostic criteria Lack of showing, bringing, etc. Little or no interest in others Uses others as tools Repeats extensive dialog Absent or impaired imaginative play Markedly restricted interests Unusual preoccupation Insists on sameness Nonfunctional routines Excessive focus on parts Visual inspection Movement preoccupation Sensory preoccupation DSM-IV-TR surveillance case definition At least six behaviors coded with a minimum of two Social, one Communication, and one Restricted Behavior/Interest; AND evidence of developmental delay or concern at or before the age of 3 years OR At least two behaviors coded with a minimum of one Social and either one Communication and/or one Restricted Behavior/Interest; AND at least one autism discriminator coded Note: A child might be disqualified from meeting the DSM-IV-TR surveillance case definition for ASD if, based on the clinical judgment of one or more reviewers, there is insufficient or conflicting information in support of ASD, sufficient information to rule out ASD, or if one or more other diagnosed conditions better account for the child’s symptoms. Abbreviations: ASD = autism spectrum disorder; DSM-IV-TR = Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision; DSM-5= Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. a score of ≤70 on their most recent test. Data on intellectual (n = 114 [18.8%], n = 114 [21.5%], and n = 225 [25.7%] for ability were included for sites for which ≥60% of children 2010, 2012, and 2014, respectively). Uncertainty surrounding meeting the ASD surveillance case definition had an intellectual the reliability of measurement of intellectual ability in early ability test score. Among those sites, children without a test childhood prevents further subclassification of intellectual score were categorized as having unknown intellectual ability ability (26,27). 6 MMWR / April 12, 2019 / Vol. 68 / No. 2 US Department of Health and Human Services/Centers for Disease Control and Prevention Surveillance Summaries BOX 2. Surveillance case definition based on behavioral criteria for diagnosis of autism spectrum disorder*: Diagnostic and Statistical Manual of Mental Disorders, 5th Edition DSM-5 behavioral criteria A. Persistent deficits in social A1: Deficits in social emotional reciprocity communication and social A2. Deficits in nonverbal communicative behaviors interaction A3. Deficits in developing, maintaining, and understanding relationships B. Restricted, repetitive patterns B1: Stereotyped or repetitive motor movements, use of objects or speech of behavior, interests, or B2. Insistence on sameness, inflexible adherence to routines, or ritualized patterns of verbal or nonverbal behavior activities, currently or by B3. Highly restricted interests that are abnormal in intensity or focus history B4. Hyperreactivity or hyporeactivity to sensory input or unusual interest in sensory aspects of the environment Historical pervasive developmental Any ASD diagnosis documented in a comprehensive evaluation, including a DSM-IV diagnosis of autistic disorder, Asperger disorder diagnosis disorder, or pervasive developmental disorder–not otherwise specified DSM-5 surveillance case definition All three behavioral criteria coded under part A, and at least two behavioral criteria coded under part B OR Any ASD diagnosis documented in a comprehensive evaluation, whether based on DSM-IV-TR or DSM-5 diagnostic criteria Note: A child might be disqualified from meeting the DSM-5 surveillance case definition for ASD if, based on the clinical judgment of one or more reviewers, there is insufficient or conflicting information in support of ASD, sufficient information to rule out ASD, or if one or more other diagnosed conditions better account for the child’s symptoms. Abbreviations: ASD = autism spectrum disorder; DSM-IV = Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition; DSM-IV-TR = Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision; DSM-V = Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. * DSM-5 also includes a previous DSM-IV diagnosis of ASD as a sole criterion for a clinical diagnosis. 8 years living in the same geographic areas. Data for 2010 Quality Assurance were previously published (28) but are included in the results All Early ADDM sites follow the same quality assurance to provide a comprehensive representation of ASD prevalence conventions established by the ADDM Network. For the and characteristics for all the years of Early ADDM Network first phase of ADDM, screening and abstraction of source surveillance, as well as a comparison among children from the records are checked periodically for accuracy. For the second sites with data from all 3 surveillance years. phase, interrater reliability receives ongoing monitoring, with The prevalence estimate of ASD among children aged a blinded, random 10% sample of abstracted records that are 4 years was calculated as the number of children aged 4 years scored independently by two reviewers. Across surveillance who met the ASD surveillance case definition in the Early years, the final average interrater agreements for determining ADDM Network sites in 2010, 2012, and 2014 divided by ASD surveillance case status in the Early ADDM study sites the number of children aged 4 years living in the surveillance ranged from 87.3% (κ = 0.74) to 91.1% (κ = 0.81) among areas according to the 2010 decennial bridged-race population children aged 4 years and from 89.2% (κ = 0.77) to 91.0% estimates (29), the vintage 2014 postcensal bridged-race (κ = 0.80) among those aged 8 years. population estimates for 2012 (http://www.cdc.gov/nchs), and the vintage 2016 postcensal bridged-race population estimates Analytic Methods for 2014 (http://www.cdc.gov/nchs). In Arizona and Utah, the surveillance area included some but not all of the school The objectives of this report are to describe ASD prevalence districts in two counties (Maricopa and Salt Lake counties, and characteristics among children aged 4 years in the Early respectively). Therefore, investigators developed a method ADDM Network for 2010, 2012, and 2014, including using census and school district data to estimate the numbers 1) overall prevalence and prevalence by sex and race/ethnicity; of children aged 4 and 8 years living in these surveillance areas. 2) characteristics of children aged 4 years with ASD, including Detailed methods are provided (Appendix). Overall prevalence age at first developmental evaluation, age at ASD diagnosis, estimates included all children identified with ASD regardless and cognitive function; and 3) trends in ASD prevalence of sex, race/ethnicity, or intellectual ability and therefore were and characteristics in the three Early ADDM sites with data unaffected by the availability of these data elements. and consistent data sources for all 3 surveillance years (2010, 2012, and 2014), including comparisons with children aged US Department of Health and Human Services/Centers for Disease Control and Prevention MMWR / April 12, 2019 / Vol. 68 / No. 2 7 Surveillance Summaries Statistical tests and 95% confidence interval (CI) estimates (New Jersey in 2014) to 70.9% (Wisconsin in 2014), and were derived under the assumption that the observed counts the percentage of black children ranged from 3.5% (Arizona of ASD surveillance cases were sampled from an underlying in 2012 and 2014) to 33.1% (New Jersey in 2014). The Poisson distribution. Because previous ADDM Network percentage of Hispanic children ranged from 4.5% (Missouri reports presented CIs based on an underlying Poisson in 2014) to 47.3% (Colorado in 2014). American Indian/ distribution with an asymptotic approximation to the Alaska Native children comprised 0.2%–3.1% of the total normal, slight differences might exist between those and the population, and Asian/Pacific Islander children comprised exact Poisson confidence intervals presented in this report. 2.7%–6.5%. The population distribution by race/ethnicity Generalized linear models with a Poisson distribution were across sites was similar for children aged 8 years. Aggregating used to calculate prevalence ratios (PRs) and CIs. Pearson data across sites for each surveillance year, the total percentages chi-square tests were used to examine frequency differences in by race/ethnicity among children aged 4 years ranged from the characteristics of children with ASD by surveillance area, 46.8% to 51.9% for white (in 2014 and 2010, respectively), sex, race/ethnicity, and intellectual ability; ASD prevalence 19.1% to 22.7% for black (in 2010 and 2014, respectively), was estimated both for children aged 4 years and 8 years 23.2% to 25.1% for Hispanic (in 2010 and 2014, respectively), living in the Early ADDM surveillance areas. Because the 4.7% to 5.0% for Asian/Pacific Islander (in 2014 and 2012, data for children aged 8 years are restricted to this smaller respectively), and 0.7% to 0.9% for American Indian/Alaska area, the estimates for those aged 8 years do not match those Native (in 2014 and 2010–2012, respectively), with similar previously published from the ADDM Network reports on percentages among children aged 8 years. ASD prevalence and characteristics (13–15). Trend analyses for ASD prevalence were restricted to the three sites (Arizona, Overall ASD Prevalence Missouri, and New Jersey) with data and consistent data Among Children Aged 4 Years sources for all 3 years; trends in the proportion of children Aggregating data across participating surveillance sites for with ASD who had co-occurring intellectual disabilities were each year, the estimated prevalence of ASD among children restricted to the two sites with data for all 3 years (Arizona aged 4 years was 13.4 per 1,000 in 2010, 15.3 in 2012, and and New Jersey). Cochran-Armitage trend tests were used to 17.0 in 2014 (Table 1). Prevalence ranged from 8.1 per 1,000 estimate the significance of changes in ASD characteristics children aged 4 years in Missouri (2012) to 28.4 in New Jersey over the 2010–2014 period. The nonparametric median (2014). For each year, aggregated ASD prevalence was higher test was used to determine differences in median age at first for study sites that reviewed education and health care records developmental evaluation and earliest known ASD diagnosis rather than health care records alone (Table 1); PRs for sites that from 2010 to 2014 and by sex and race/ethnicity within reviewed both types compared with only health care records surveillance years. PRs with CIs that did not include 1.00 were 1.8 (95% CI: 1.6–2.2) in 2010, 1.6 (95% CI: 1.4–1.8) were used to assess whether ASD prevalence was higher in in 2012, and 1.7 (95% CI: 1.5–2.0) in 2014 (data not shown). one population than another. For results from chi-square, Cochran-Armitage, and median tests, a p value of <0.05 was considered significant. Analyses were performed using SAS ASD Prevalence (version 9.4; SAS Institute). Among Children Aged 4 Years by Sex and Race/Ethnicity Across all sites and years, ASD prevalence per 1,000 boys Results aged 4 years ranged from 12.2 in Missouri (2010) to 44.0 Population Distribution in New Jersey (2014) (Table 2). Prevalence per 1,000 girls aged 4 years ranged from 3.2 in Missouri (2012) to 12.1 The overall Early ADDM Network geographic surveillance in New Jersey (2014). Male-to-female PRs indicated ASD area includes the seven sites that participated in at least one prevalence was higher among boys than girls in all sites and surveillance year (Figure 1). The Early ADDM Network years, ranging from 2.6 (Arizona and Wisconsin in 2010) to comprised a population from 58,467 (2010) to 70,887 (2014) 5.2 boys per one girl (Colorado in 2014). children aged 4 years and 56,727 (2010) to 71,928 (2014) Across all study sites and years for children aged 4 years, children aged 8 years (Supplemental Table 1, https://stacks. prevalence among white children ranged from 7.7 per 1,000 cdc.gov/view/cdc/76016). The distribution of children by in Missouri (2014) to 29.3 in New Jersey (2014) (Table 3). race/ethnicity varied across the sites. Among children aged Prevalence among black children ranged from 3.8 per 1,000 4 years, the percentage of white children ranged from 29.4% 8 MMWR / April 12, 2019 / Vol. 68 / No. 2 US Department of Health and Human Services/Centers for Disease Control and Prevention Surveillance Summaries in Missouri (2010) to 24.7 in New Jersey (2014). Prevalence ASD Diagnosis from a Community among Hispanic children ranged from 9.1 per 1,000 (in Provider Among Children Aged 4 Years Arizona (2010) to 28.2 in New Jersey (2014). In 2010, white The percentage of children with a documented ASD children had a higher ASD prevalence than Hispanic children in diagnosis from a community provider ranged from 43.0% Arizona (PR = 1.7) and black children in Missouri (PR = 2.5); in Arizona (2012) to 86.5% in Missouri (2012) but did not no other differences were observed by race/ethnicity. vary by sex (Table 6). The median age at first known ASD diagnosis ranged from 28 months in North Carolina (2014) Frequency of Co-Occurring to 39.0 months in Missouri and Wisconsin (2012). Among the Intellectual Disabilities three sites with data for all 3 surveillance years and consistent data sources, no significant trends were found in the proportion Among Children Aged 4 and 8 Years of children with an ASD diagnosis, overall or by sex Scores on intellectual ability tests were available for at least 60% of children in four sites for at least one surveillance year (Arizona, New Jersey, North Carolina, and Utah). These sites Trends in ASD Prevalence all reviewed education and health care records. In the two Among Children Aged 4 and 8 Years sites (Arizona and New Jersey) with data for all surveillance Four Early ADDM Network sites (Arizona, Missouri, New years, the percentage of children aged 4 years with ASD who Jersey, and Wisconsin) participated in all 3 surveillance years; had co-occurring intellectual disabilities was stable over time however, Wisconsin reviewed early intervention records in at 47.0%, 43.6%, and 46.0% in 2010, 2012, and 2014, 2014 but not earlier years, whereas data sources for other respectively (test for trend p value = 0.84) and also was stable sites were consistent across years. Among children aged over time among both boys and girls (Table 4). The proportion 4 years, ASD prevalence was higher in 2014 than in 2010 in of children with ASD who had co-occurring intellectual New Jersey (PR: 1.4) but not in Arizona or Missouri (Figure 2; disabilities was significantly higher among children aged 4 years Supplemental Table 4, https://stacks.cdc.gov/view/cdc/76016). than among those aged 8 years across all sites and surveillance In Wisconsin, ASD prevalence was higher in 2012 and 2014 years, with the exception of Arizona (2010) (Supplemental than in 2010. Among children aged 8 years living in the Early Table 2, https://stacks.cdc.gov/view/cdc/76016). ADDM Network geographical areas, ASD prevalence was higher in 2014 than in 2010 in New Jersey (PR: 1.3) but not Age at First Comprehensive in the other sites. In Missouri and Wisconsin, ASD prevalence was higher Developmental Evaluation among children aged 8 years than among those aged 4 years in Among Children Aged 4 Years all 3 years (Supplemental Table 4, https://stacks.cdc.gov/view/ Across all participating sites and surveillance years and cdc/76016). In Arizona, ASD prevalence was higher among among children born in the state where the ADDM Network children aged 8 years than among those aged 4 years in 2012 site was located, the percentage of children who received only, and in New Jersey, no differences by age were found. their first comprehensive developmental evaluation by age 36 months ranged from 48.8% (Missouri in 2012) to 88.9% ASD Prevalence Using DSM-IV-TR and (Wisconsin in 2014) (Table 5). Among the three sites with data and consistent data sources for all 3 years, patterns in the DSM-5 Case Definitions age at the first developmental evaluation varied by site. No A revised ADDM Network ASD surveillance case definition trend was observed in Arizona or Missouri. In New Jersey, was developed for the 2014 surveillance year to provide ASD from 2010 to 2014, the percentage of children who received a prevalence estimates based on the updated DSM-5 diagnostic first evaluation by age 36 months decreased significantly (from criteria published in 2013. All sites reviewed children’s 76.5% to 66.7%). In Wisconsin, the percentage of children records in the Early ADDM Network by both surveillance who received a first developmental evaluation by age 36 months case definitions to evaluate the effect on estimated prevalence was higher in 2014 (88.9%), when early intervention records because of the change to DSM-5 diagnostic criteria. Among were reviewed, than in 2010 and 2012 (69.0% and 73.4%, children aged 4 years in the Early ADDM Network in 2014, respectively). Percentages stratified by sex and race/ethnicity the prevalence of ASD using the DSM-5 surveillance case by site are provided (Supplemental Table 3, https://stacks.cdc. definition was 14.1 compared with 17.0 for DSM-IV-TR gov/view/cdc/76016). (DSM-IV-TR-to-DSM-5  PR:  1.2) (Table 7). Among US Department of Health and Human Services/Centers for Disease Control and Prevention MMWR / April 12, 2019 / Vol. 68 / No. 2 9 Surveillance Summaries FIGURE 2. Trends in autism spectrum disorder prevalence* among children aged 4 years and 8 years — Early Autism and Developmental Disabilities Monitoring Network, three sites, United States, 2010, 2012, and 2014 4 years 8 years 2010 2012 2014 2010 2012 2014 2010 2012 2014 Year Year Year Arizona Missouri New Jersey * In Arizona in 2012, the prevalence among children aged 4 years and children aged 8 years was significantly different (p<0.05 for chi-square test). In Missouri, the prevalence was significantly different in all 3 years. (In New Jersey, no differences were significant in any years.) 1,237 children who met the surveillance case definition for The overall prevalence estimate using a DSM-IV-TR case either DSM-IV-TR or DSM-5, 974 (78.7%) met both case definition was approximately 20% higher than the prevalence definitions, 234 (18.9%) met the DSM-IV-TR but not the estimate based on DSM-5 criteria. Meeting the DSM-5 DSM-5 case definition, and 29 (2.3%) met the DSM-5 but surveillance case definition required either documentation of not the DSM-IV-TR case definition. the more extensive behavioral criteria required for a DSM-5 diagnosis or an ASD diagnosis by a community provider, and preschool-aged children might have had fewer comprehensive evaluations containing behavioral information and been less Discussion likely to have a diagnosis. For the 2016 surveillance year, all This report provides data on ASD prevalence among children ADDM Network surveillance sites will use the DSM-5 case aged 4 years using ADDM surveillance methods across several definition, and trends in the prevalence of ASD among children sites participating in the Early ADDM Network during 2010, aged 4 years and 8 years will be monitored according to this 2012, and 2014. Among these children aged 4 years, overall surveillance case definition. estimated ASD prevalence was 13.4 per 1,000 in 2010, 15.3 in The estimated ASD prevalence in sites that reviewed both 2012, and 17.0 in 2014. ASD prevalence was higher among boys education and health care records was 60%–80% higher than than girls. Across all sites and surveillance years, few differences the estimated ASD prevalence among sites that reviewed in ASD prevalence were found by race/ethnicity among children only health care records. Although ASD prevalence varied aged 4 years, and those that were identified occurred in 2010 even among sites that reviewed education records, the total but not in later years. In the four sites that participated in Early prevalence among these sites (15.9, 17.4, and 19.3 per ADDM Network surveillance in all 3 years, ASD prevalence 1,000 children aged 4 years, respectively, for 2010–2014) is among children aged 4 years was approximately 40% higher likely a more sensitive estimate of ASD prevalence among in New Jersey in 2014 than in 2010 and similar across the children aged 4 years, suggesting that the overall estimated years in Arizona and Missouri. In Wisconsin, ASD prevalence ASD prevalence in the Early ADDM Network would have was significantly higher in 2014 than in 2010. However, the been higher had all sites had access to education records. availability of early intervention records in 2014 but not in Early intervention records also are an important source of earlier years might have influenced the prevalence estimates for information, particularly for tracking the age at earliest that year, even though prevalence was similar in 2012 when early evaluation. For example, the percentage of children evaluated intervention records were not reviewed. 10 MMWR / April 12, 2019 / Vol. 68 / No. 2 US Department of Health and Human Services/Centers for Disease Control and Prevention Prevalence per 1,000 children aged 4 or 8 years Surveillance Summaries by age 36 months in Wisconsin was higher when early In addition to the findings among preschool-aged children, intervention records were included for 2014 but not for earlier studies using different surveillance methods also have identified years. Together, these findings suggest that early intervention higher ASD prevalence among children in recent years and public education systems are a critical community resource (5–15,35). Several studies highlight changes in community for the evaluation of preschool-aged children who exhibit practice for recognizing and diagnosing ASD in children with social, communication, and behavioral impairments. Lack of developmental concerns, as well as expansion of the diagnostic access to early intervention and education records, combined criteria for ASD during 1987–2013 to include children with with indications from earlier reports (10–15) that many fewer or more mild symptoms, as factors contributing to the children with ASD are not evaluated until after age 4 years, higher prevalence (36–39). Although assessing whether ASD suggests that the estimate of ASD prevalence among children prevalence trends are, in part, associated with changes in aged 4 years might be an underestimate of the actual ASD etiologic risk is not possible with ADDM Network data, the prevalence in this birth cohort. heterogeneity of Early ADDM Network prevalence estimates across study sites, even among sites that reviewed both education and health care records, supports the hypothesis Other Studies of ASD Prevalence that differences in evaluation, diagnostic, and service practices Population-based data on the prevalence of ASD in affect measured prevalence. Previous data from the ADDM preschool-aged children are limited, and various case Network indicate a lower proportion of children with ASD ascertainment methods have been used; nevertheless, studies with co-occurring intellectual disabilities (10–15) over time, indicate that the prevalence of ASD in this age group has been consistent with improvements in the identification of children higher in recent years. In 1996, estimated ASD prevalence who have milder ASD. In addition, changes in the availability among children aged 4 years in MADDSP was 3.1 per 1,000 of services for children with ASD through insurance mandates (95% CI: 2.6–3.7), and the estimated prevalence per 1,000 (40), willingness of parents and providers to consider an ASD children aged 8 years was 4.7 (95% CI: 4.0–5.5) (16). A diagnosis, and greater awareness of and concern regarding ASD study using similar methods conducted in Brick Township, might contribute to the higher prevalence. New Jersey, reported an estimated ASD prevalence of 7.8 per 1,000 children aged 3–5 years (95% CI: 5.1–11.3) in Early Identification of and 1998 (30). A study from South Carolina in 2006 using MADDSP methods found an ASD prevalence of 8.0 per 1,000 Intervention for ASD children aged 4 years (31). A population-based study in the The American Academy of Pediatrics prioritized the early United Kingdom during 1998–1999 that used a multistage identification of ASD through its recommendation for screening and diagnosis methodology to identify children universal ASD screening during pediatric preventive care visits with PDD reported a prevalence estimate of 6.3 per 1,000 at ages 18 and 24 months (22) and by the U.S. Department children aged 3.5–6.5 years (32). Another study using the same of Health and Human Services through the Healthy People methods that was conducted several years later in a subsequent 2020 goal to increase the proportion of children with ASD who birth cohort reported a prevalence estimate of 5.9 per 1,000 receive their first evaluation by age 36 months. Evidence linking children aged 4–6 years (33). Approximately 10 years later, a early treatment for ASD with improved outcomes (18–21,41) report from the 2007 National Survey of Children’s Health implies that an absence or a delay in ASD identification could (NSCH) described estimated ASD prevalence by parent or delay interventions and initiation of special services. Identifying caregiver report to be 8.5 per 1,000 children aged 3–5 years the need for special services before school entry to minimize (95% CI: 6.0–12.0), compared with 13.2 per 1,000 children educational disruption and optimize educational outcomes aged 6–8 years (95% CI: 9.6–18.3) (6,34). Most recently, the might be especially important. 2016 NSCH reported ASD prevalence estimates of 19.7 per In this report, across all sites and surveillance years, the 1,000 children aged 3–5 years, 26.1 per 1,000 children aged median age at first known ASD evaluation among children 6–11 years, and 26.5 per 1,000 children aged 12–17 years aged 4 years with ASD ranged from 23 to 37 months, and (9). The most recent data from the National Health Interview 48.8% to 88.9% received their first ASD evaluation by age Survey showed a prevalence estimate (based on parent or 36 months. The percentage of children with an ASD diagnosis caregiver report) of 22.3 per 1,000 children aged 3–7 years in varied widely by study site, ranging from 43.0% to 86.5%, with 2016, which was lower than the prevalence estimate among sites that reviewed only health care records generally reporting children aged 8–12 years (28.8) (34). a greater percentage of children with an ASD diagnosis. This is not unexpected because other sites include children based US Department of Health and Human Services/Centers for Disease Control and Prevention MMWR / April 12, 2019 / Vol. 68 / No. 2 11 Surveillance Summaries wholly or partly on review of education records, which might Limitations not contain a formal ASD diagnosis. Among sites with data This report is subject to several limitations. First, because from all surveillance years and consistent data sources, the age these ASD prevalence estimates are based on a record review, at first evaluation was stable from 2010 to 2014 in Arizona and with no clinical examination, Early ADDM Network data Missouri. In New Jersey, the age at first evaluation increased reflect the information available in the source records. The from 2010 to 2014. The Wisconsin site gained access to records amount and quality of the data determine the potential for from early intervention services for children aged <3 years a child to meet the ASD surveillance case definition and the for the 2014 surveillance year, which likely contributed to extent to which they can be used to describe the characteristics detecting a greater number of children with a first evaluation of the identified population. Some children with ASD might by age 36 months. Age at first evaluation might be easier not have been included because their records were incomplete to lower than age at diagnosis because diagnosing ASD in or not available or they had not come to the attention of young children is challenging, which might be related to the schools or clinical providers, which might have resulted in an prodromal nature of autism’s phenotypic onset that has recently underestimate of the ASD prevalence. Second, the types of become apparent through longitudinal studies of infant siblings source records varied across surveillance sites, and the lack of at high risk for autism (42). However, greater awareness of availability of education or early intervention records at some ASD might result in more children being identified, including sites might have led to an underestimate of ASD prevalence those with symptoms that do not fully manifest until the among children aged 4 years in those sites and consequently for child is close to school age, increasing prevalence while also the Early ADDM Network overall. Third, early diagnoses of increasing the age of identification. Prevalence was higher ASD might change if another diagnosis is determined to better among children aged 8 years than among those aged 4 years in account for a child’s signs and symptoms (6,43,44), potentially some sites, which might reflect the identification of children affecting the specificity of records-based surveillance. However, with milder symptoms later in development or on school entry; the ADDM Network clinician review process allows clinicians this is supported by the difference in frequency of co-occurring to change the ASD surveillance case status, even if the child intellectual disabilities between children aged 4 and 8 years. has a previous ASD diagnosis, which helps decrease potential Efforts to identify developmental concerns as early as possible overestimates. Fourth, the availability of early intervention and decrease the age at first evaluation for all children with ASD records in Wisconsin for 2014 but not for earlier years are warranted. As recommended by the American Academy prevented the interpretation of changes in prevalence as well the of Pediatrics, universal screening might identify children age at earliest developmental evaluation and ASD diagnosis for who need a comprehensive evaluation for ASD, even in the that site. Fifth, measurement of intellectual ability in preschool- absence of previous developmental concerns or co-occurring aged children is less reliable than measurement among school- intellectual disabilities, and improved tools for discerning the aged children (26,27), preventing more specific classification signs of ASD among the range of typical childhood behaviors of intellectual ability among children with ASD other than might aid efforts to identify children earlier. Public health the presence or absence of intellectual disability. Sixth, data on campaigns such as Learn the Signs. Act Early. (https://www. intellectual ability were not available for all children, and the cdc.gov/ncbddd/actearly/index.html) provide informational distribution of intellectual ability among the children with these materials for parents, providers, and community members data might not be generalizable to all children with ASD in the aimed at improving awareness of developmental milestones Early ADDM Network if the data on intellectual ability are not and increasing early identification of developmental delays so randomly missing. For example, children without a cognitive that children can receive appropriate services and treatments test score might not have been tested because their intellectual as early as possible. ability was clearly in the average to above-average range, thus No significant trends were found in the percentage of overestimating the proportion of children with ASD and children with a documented ASD diagnosis or in the age at co-occurring intellectual disabilities. Seventh, the surveillance earliest known diagnosis. Children with an early evaluation sites were selected through a competitive process and were not can begin to receive behavioral and developmental services selected to be representative of children aged 4 years either in and interventions even if a formal ASD diagnosis is not made the United States or in the entire state in which surveillance at that time. However, a formal diagnosis might be necessary occurred. Therefore, the estimated prevalence of ASD is limited to receive certain ASD services; therefore, the 35%–40% of to the surveillance areas. Finally, analyses of trends were limited children who met the ASD surveillance case definition but did to three sites with data and consistent data sources for all 3 not have a documented ASD diagnosis might not be eligible surveillance years, and within sites, data were sparse for certain for services that depend on an ASD diagnosis. 12 MMWR / April 12, 2019 / Vol. 68 / No. 2 US Department of Health and Human Services/Centers for Disease Control and Prevention Surveillance Summaries race/ethnicity groups. In addition, patterns of ASD prevalence sites. However, variations in prevalence did not always align and characteristics varied by site; therefore, in some cases, data with access to data sources, and differences in evaluation and could not be combined, limiting the statistical power. diagnostic services among different areas might account for some differences in findings across surveillance sites. This suggests that opportunities for improvements in services might exist based on Estimating ASD Prevalence Using successful programs implemented in specific areas. Continuing Surveillance Data improvements in providing developmental evaluations to children Surveillance data from the Early ADDM Network provides as soon as developmental concerns are identified might result 1) population-based ascertainment of ASD using multiple in earlier ASD diagnoses and earlier receipt of services, which community data sources, including education and early might improve developmental outcomes. No treatment for ASD intervention records for some sites; 2) inclusion of children is available, although interventions might maximize each child’s with documentation of behaviors consistent with ASD but ability to function and participate in the community (18–21,41). without a documented ASD diagnosis; 3) data on intellectual Conflicts of Interest disability based on standardized tests of intellectual ability; and 4) collection of information on the age at first comprehensive Deborah Bilder reports personal fees from Audentes Therapeutics evaluation and ASD diagnosis, when present, that provide and personal fees from BioMarin Pharmaceuticals outside the submitted work. John Constantino receives royalties from Western information on early identification of children with ASD. The Psychological Services for the commercial distribution of the Social record review method allows population-based estimates of ASD Responsiveness Scale. prevalence to be generated cost-effectively. 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Blumberg SJ, Zablotsky B, Avila RM, Colpe LJ, Pringle BA, Kogan MD. mental disorders. 4th ed, Text Revision. Washington, DC: American Diagnosis lost: differences between children who had and who currently Psychiatric Association; 2000. have an autism spectrum disorder diagnosis. Autism 2016;20:783–95. 26. Lord C, Schopler E. The role of age at assessment, developmental level, https://doi.org/10.1177/1362361315607724 and test in the stability of intelligence scores in young autistic children. 45. Avchen RN, Wiggins LD, Devine O, et al. Evaluation of a records- J Autism Dev Disord 1989;19:483–99. https://doi.org/10.1007/ review surveillance system used to determine the prevalence of autism BF02212853 spectrum disorders. J Autism Dev Disord 2011;41:227–36. https://doi. org/10.1007/s10803-010-1050-7 14 MMWR / April 12, 2019 / Vol. 68 / No. 2 US Department of Health and Human Services/Centers for Disease Control and Prevention Surveillance Summaries Appendix Detailed Method for Estimating Surveillance Area Population Size of Partial Counties For 2010, the number of children aged 4 years by sex and race/ethnicity was obtained for each census tract in the county from the 2010 decennial census counts. Next, each census tract was matched to the school district or districts to which it was fully or partially allocated, using the MABLE/Geocorr12: Geographic Correspondence Engine provided by the Missouri Census Data Center (http://mcdc.missouri.edu). A list of excluded or partially excluded census tracts was compiled, and the number of children aged 4 years living in these census tracts was subtracted from the overall and sex- and race-specific total numbers of children in the county. For census tracts that were partially allocated to a school district, weighting was based on the 2010 census population of the county. Finally, population counts of children aged 4 years in each specific census race/ethnicity category (white, black, American Indian/Alaska Native, Asian/Pacific Islander, other race/ethnicity, multiracial, and Hispanic) were adjusted to the distribution of the National Center on Health Statistics (NCHS) bridged-race category counts for the county, thereby incorporating children categorized in the census counts as multiracial or other race into the bridged-race categories reported by NCHS (white, black, Hispanic, American Indian/Alaska Native, and Asian/Pacific Islander). The same methods were used to estimate the prevalence of ASD among children aged 8 years living in the Early ADDM Network surveillance area. For the nondecennial census years 2012 and 2014, denominators for sites that covered less than a full county were estimated by using school enrollment counts for the appropriate grades in the covered area and applying the distribution of these counts to the county-level bridged-race postcensal population estimates from NCHS (http://www.cdc.gov/nchs). US Department of Health and Human Services/Centers for Disease Control and Prevention MMWR / April 12, 2019 / Vol. 68 / No. 2 15 Surveillance Summaries TABLE 1. Prevalence* of autism spectrum disorder among children TABLE 2. Prevalence* of autism spectrum disorder among children aged 4 years — Autism and Developmental Disabilities Monitoring aged 4 years, by sex — Early Autism and Developmental Disabilities Network, seven sites, United States, 2010, 2012, and 2014 Monitoring Network, seven sites, United States, 2010, 2012, and 2014 Sex Year, record source, No. with Total and site ASD population Prevalence (95% CI) Male Female Year, Prevalence ratio, record source, Prevalence Prevalence male to female Health care and education † and site (95% CI) (95% CI) (95% CI) Arizona 123 9,265 13.3 (11.0–15.8) §,¶ New Jersey 352 17,860 19.7 (17.7–21.9) ¶, Health care and education Utah ** 132 10,944 12.1 (10.1–14.3) Arizona 18.9 (15.2–23.3) 7.3 (5.0–10.3) 2.6 (1.7–3.9) Total 607 38,069 15.9 (14.7–17.3) New Jersey 31.7 (28.1–35.5) 7.2 (5.5–9.2) 4.4 (3.3–5.8) Health care only †† Utah 17.9 (14.6–21.7) 5.9 (4.0–8.3) 3.1 (2.0–4.6) Missouri 103 12,095 8.5 (7.0–10.3) §§ Health care only Wisconsin 73 8,303 8.8 (6.9–11.1) Missouri 12.2 (9.6–15.3) 4.6 (3.0–6.7) 2.7 (1.7–4.1) Total 176 20,398 8.6 (7.4–10.0) Wisconsin 12.5 (9.4–16.4) 4.8 (2.9–7.4) 2.6 (1.6–4.4) Combined total 783 58,467 13.4 (12.5–14.4) Health care and education Health care and education Arizona 21.3 (17.5–25.8) 4.6 (2.8–7.0) 4.7 (2.9–7.5) Arizona 128 9,621 13.3 (11.1–15.8) New Jersey 33.6 (30.0–37.5) 9.9 (8.0–12.2) 3.4 (2.7–4.3) New Jersey 403 18,223 22.1 (20.0–24.4) Utah 20.7 (17.2–24.8) 5.7 (3.9–8.1) 3.6 (2.5–5.4) Utah 152 11,398 13.3 (11.3–15.6) Health care only Total 683 39,242 17.4 (16.1–18.8) Missouri 12.9 (10.2–16.2) 3.2 (1.9–5.0) 4.0 (2.4–6.7) Health care only Wisconsin 23.7 (19.4–28.8) 6.4 (4.2–9.4) 3.7 (2.4–5.7) Missouri 96 11,878 8.1 (6.5–9.9) Wisconsin 128 8,336 15.4 (12.8–18.3) Health care and education Total 224 20,214 11.1 (9.7–12.6) Arizona 21.3 (17.4–25.8) 5.2 (3.3–7.7) 4.1 (2.7–6.4) Combined total 907 59,456 15.3 (14.3–16.3) Colorado 22.3 (18.1–27.3) 4.3 (2.5–6.8) 5.2 (3.1–8.6) 2014 § New Jersey 44.0 (39.9–48.5) 12.1 (10.0–14.7) 3.6 (2.9–4.5) Health care and education North 24.7 (21.3–28.5) 5.8 (4.2–7.8) 4.2 (3.0–5.9) Arizona 130 9,624 13.5 (11.3–16.0) Carolina ¶¶ Colorado 113 8,438 13.4 (11.0–16.1) Health care only New Jersey 514 18,112 28.4 (26.0–30.9) Missouri 14.2 (11.3–17.5) 4.8 (3.2–7.0) 3.0 (1.9–4.6) ¶, North Carolina *** 231 14,893 15.5 (13.6–17.6) § Wisconsin 20.8 (16.7–25.6) 4.8 (2.9–7.6) 4.3 (2.6–7.1) Total 988 51,067 19.3 (18.2–20.6) Abbreviations: CI = confidence interval; PR = prevalence ratio. Health care only * Prevalence per 1,000 children age 4 years living in the surveillance areas Missouri 112 11,613 9.6 (7.9–11.6) according to the 2010 decennial bridged-race population estimates (US Census Wisconsin 108 8,207 13.2 (10.8–15.9) Bureau. Census summary file 1: Tables PCT12H–PCT12O. Washington, DC: Total 220 19,820 11.1 (9.7–12.7) US Census Bureau; 2010), the vintage 2014 postcensal bridged-race population Combined total 1,208 70,887 17.0 (16.1–18.0) estimates for 2012 (http://www.cdc.gov/nchs), and the vintage 2016 postcensal bridged-race population estimates for 2014 (http://www.cdc.gov/nchs). Abbreviations: ASD = autism spectrum disorder; CI = confidence interval. Results for PRs considered statistically significant when the CI excludes the * Prevalence per 1,000 children aged 4 years living in the surveillance areas null value (PR = 1.0). according to the 2010 decennial bridged-race population estimates Site also reviewed records from early intervention sources. (US Census Bureau. Census summary file 1: Tables PCT12H–PCT12O. Washington, DC: US Census Bureau; 2010), the vintage 2014 postcensal bridged-race population estimates for 2012 (http://www.cdc.gov/nchs), and the vintage 2016 postcensal bridged-race population estimates for 2014 (http://www.cdc.gov/nchs). Part of one county in metropolitan Phoenix for 2010, 2012, and 2014. Essex and Union counties for 2010, 2012, and 2014. Site also reviewed records from early intervention sources. ** Tooele County, part of Salt Lake County, for 2010 and 2012 only. †† One county in metropolitan St. Louis for 2010, 2012, and 2014. §§ Dane and Rock counties for 2010, 2012, and 2014. ¶¶ One county in metropolitan Denver for 2014 only. *** Alamance, Chatham, Guilford, Orange, and Forsyth counties for 2014 only. 16 MMWR / April 12, 2019 / Vol. 68 / No. 2 US Department of Health and Human Services/Centers for Disease Control and Prevention Surveillance Summaries TABLE 3. Prevalence* of autism spectrum disorder among children aged 4 years, by race/ethnicity — Early Autism and Developmental Disabilities Monitoring Network, seven sites, United States, 2010, 2012, and 2014 Prevalence (95% CI) Prevalence ratio (95% CI) Year, record source, and site White, non-Hispanic Black, non-Hispanic Hispanic White to black White to Hispanic Health care and education Arizona 15.7 (12.4–19.7) — 9.1 (6.2–12.9) — 1.7 (1.1–2.6) New Jersey 18.9 (15.5–22.7) 16.7 (13.6–20.4) 22.5 (18.6–27.0) 1.1 (0.9–1.5) 0.8 (0.6–1.1) Utah 14.0 (11.3–17.2) — 9.8 (6.7–13.8) — 1.4 (1.0–2.1) Health care only Missouri 9.3 (7.2–11.9) 3.8 (2.1–6.4) 14.4 (6.2–28.4) 2.5 (1.4–4.4) 0.6 (0.3–1.4) Wisconsin 8.2 (6.0–10.9) — — — — Health care and education Arizona 14.5 (11.4–18.1) 20.7 (8.3–42.7) 9.9 (6.8–13.8) 0.7 (0.3–1.5) 1.5 (1.0–2.2) New Jersey 24.2 (20.3–28.5) 19.3 (15.9–23.1) 22.3 (18.6–26.6) 1.3 (1.0–1.6) 1.1 (0.8–1.4) Utah 14.3 (11.5–17.5) — 11.3 (8.1–15.4) — 1.3 (0.9–1.8) Health care only Missouri 8.3 (6.3–10.8) 7.6 (5.1–11.0) — 1.1 (0.7–1.7) — Wisconsin 13.9 (11.0–17.2) 7.6 (3.0–15.6) 15.6 (9.1–24.9) 1.8 (0.8–4.0) 0.9 (0.5–1.5) Health care and education Arizona 15.2 (12.0–18.8) 14.9 (4.8–34.8) 11.1 (7.8–15.4) 1.0 (0.4–2.5) 1.4 (0.9–2.0) Colorado 11.7 (8.3–16.2) 18.0 (10.5–28.9) 12.3 (9.1–16.2) 0.7 (0.4–1.2) 1.0 (0.6–1.5) New Jersey 29.3 (24.8–34.2) 24.7 (20.9–29.0) 28.2 (24.1–32.8) 1.2 (0.9–1.5) 1.0 (0.8–1.3) North Carolina 14.6 (11.8–17.8) 16.8 (13.2–21.0) 10.9 (7.5–15.3) 0.9 (0.6–1.2) 1.3 (0.9–2.0) Health care only Missouri 7.7 (5.8–10.1) 10.4 (7.3–14.3) — 0.7 (0.5–1.1) — Wisconsin 13.1 (10.3–16.3) 9.7 (4.2–19.1) 11.5 (5.9–20.0) 1.3 (0.6–2.8) 1.1 (0.6–2.1) Abbreviations: CI = confidence interval; PR = prevalence ratio. * Prevalence per 1,000 children aged 4 years living in the surveillance areas according to the 2010 decennial bridged-race population estimates (US Census Bureau. Census summary file 1: Tables PCT12H–PCT12O. Washington, DC: US Census Bureau; 2010), the vintage 2014 postcensal bridged-race population estimates for 2012 (http://www.cdc.gov/nchs), and the vintage 2016 postcensal bridged-race population estimates for 2014 (http://www.cdc.gov/nchs). Results for PRs considered statistically significant when the CI excludes the null value (PR = 1.0). Site also reviewed records from early intervention sources. Estimates suppressed due to small cell sizes (N<5). TABLE 4. Number and percentage of children with co-occurring intellectual disability* among children aged 4 years with autism spectrum disorder, by site, sex, and year — Early Autism and Developmental Disabilities Monitoring Network, four sites, United States, 2010, 2012, and 2014 2010 2012 2014 2010–2014 Children Children Children Children Children Children with cognitive with co-occurring with cognitive with co-occurring with cognitive with co-occurring test scores intellectual disability test scores intellectual disability test scores intellectual disability No. No. No. Site and (% of children (% of children (% of children sex with ASD) No. (%) with ASD) No. (%) with ASD) No. (%) p value Site Arizona 105 (85.4) 43 (41.0) 80 (62.5) 33 (41.3) 90 (69.2) 45 (50.0) 0.21 New Jersey 291 (82.7) 143 (49.1) 337 (83.6) 149 (44.2) 418 (81.3) 189 (45.2) 0.34 North — — — — 142 (61.5) 64 (45.1) — Carolina Utah 97 (73.5) 40 (41.2) — — — — — Sex** Male 312 (82.3) 152 (48.7) 334 (79.1) 146 (43.7) 409 (79.9) 191 (46.7) 0.65 Female 84 (87.5) 34 (40.5) 83 (76.1) 36 (43.4) 99 (75.0) 43 (43.4) 0.69 Total** 396 (83.4) 186 (47.0) 417 (78.5) 182 (43.6) 508 (78.9) 234 (46.1) 0.84 Abbreviation: ASD = autism spectrum disorder. * Defined as a score of ≤70 on the most recent standardized cognitive ability test. Including sites for which at least 60% of children with ASD had cognitive ability test score data for at least 1 surveillance year. Cochran-Armitage trend test for percentage with intellectual disability; p<0.05 indicates statistical significance. No or insufficient data for site and surveillance year. ** Data restricted to sites with information for all 3 years (Arizona and New Jersey). US Department of Health and Human Services/Centers for Disease Control and Prevention MMWR / April 12, 2019 / Vol. 68 / No. 2 17 Surveillance Summaries TABLE 5. Median age at earliest known comprehensive evaluation and percentage of children evaluated by age 36 months among children aged 4 years with autism spectrum disorder — Early Autism and Developmental Disabilities Monitoring Network, seven sites, United States, 2010, 2012, and 2014 2010 2012 2014 No. (%) with No. (%) with No. (%) with Site and Median age Total no. evaluation Median age Total no. evaluation Median age Total no. evaluation record source (months) with ASD by 36 months (months) with ASD by 36 months (months) with ASD by 36 months p value* Health care and education Arizona 34.0 95 58 (61.1) 32.0 110 74 (67.3) 32.5 110 76 (69.1) 0.23 † † † † † † § Colorado — — — — — — 34.0 93 75 (80.6) — New Jersey 26.0 307 235 (76.5) 29.0 344 271 (78.8) 34.0 403 269 (66.7) 0.002 † † † † † † § North Carolina — — — — — — 23.0 198 164 (82.8) — † † † § Utah 32.0 107 75 (70.1) 32.0 115 72 (62.6) — — — — Health care only Missouri 30.0 88 61 (69.3) 37.0 80 39 (48.8) 29.0 90 67 (74.4) 0.46 Wisconsin 27.5 58 40 (69.0) 29.0 109 80 (73.4) 24.0 90 80 (88.9) — Abbreviation: ASD = autism spectrum disorder. * Cochran-Armitage trend test for proportion with evaluation by age 36 months; p<0.05 indicates statistical significance. No data for site and surveillance year. Trend not estimated for sites with <3 years of data. Trend not estimated because records were included from early intervention sources for 2014 but not earlier years. TABLE 6. Number and percentage of children aged 4 years with a previous autism spectrum disorder diagnosis and median age at earliest known diagnosis — Early Autism and Developmental Disabilities Monitoring Network, seven sites, United States, 2010, 2012, and 2014 2010 2012 2014 2010–2014 Median age Median age Median age (months) (months) (months) No. (%) of earliest No. (%) of earliest No. (%) of earliest with any known with any known with any known Site and Total no. ASD ASD Total no. ASD ASD Total no. ASD ASD record source with ASD diagnosis diagnosis with ASD diagnosis diagnosis with ASD diagnosis diagnosis p value* Health care and education Arizona 123 53 (43.1) 35.0 128 55 (43.0) 36.0 130 56 (43.1) 36.0 1.0 † † † † † † § Colorado — — — — — — 113 72 (63.7) 31.0 — New Jersey 352 207 (58.8) 32.5 403 236 (58.6) 35.0 514 292 (56.8) 33.5 0.54 † † † † † † § North Carolina — — — — — — 231 107 (46.3) 28.0 — † † † § Utah 132 106 (80.3) 35.0 152 122 (80.3) 35.0 — — — — Health care only Missouri 103 84 (81.6) 34.0 96 83 (86.5) 39.0 112 96 (85.7) 36.0 0.41 Wisconsin 73 61 (83.6) 34.0 128 93 (72.7) 39.0 108 77 (71.3) 33.0 — Abbreviation: ASD = autism spectrum disorder. * Cochran-Armitage trend test for percentage with any ASD diagnosis; p<0.05 indicates statistical significance. No data for site for surveillance year. Trend not estimated for sites with <3 years of data. Trend not estimated because records were included from early intervention sources for 2014 but not earlier years. 18 MMWR / April 12, 2019 / Vol. 68 / No. 2 US Department of Health and Human Services/Centers for Disease Control and Prevention Surveillance Summaries TABLE 7. Number and prevalence* of children aged 4 years meeting DSM-IV-TR or DSM-5 autism spectrum disorder case definition — Autism and Developmental Disabilities Monitoring Network, seven sites, United States, 2014 DSM-IV-TR DSM-5 Prevalence ratio (95% CI), Site and record source No. Prevalence (95% CI) No. Prevalence (95% CI) DSM-IV-TR to DSM-5 Health care and education Arizona 130 13.5 (11.3–16.0) 102 10.6 (8.6–12.9) 1.3 (1.0–1.7) Colorado 113 13.4 (11.0–16.1) 93 11.0 (8.9–13.5) 1.2 (0.9–1.6) New Jersey 514 28.4 (26.0–30.9) 406 22.4 (20.3–24.7) 1.3 (1.1–1.4) North Carolina 231 15.5 (13.6–17.6) 204 13.7 (11.9–15.7) 1.1 (0.9–1.4) Health care only Missouri 112 9.6 (7.9–11.6) 105 9.0 (7.4–10.9) 1.1 (0.8–1.4) Wisconsin 108 13.2 (10.8–15.9) 93 11.3 (9.1–13.9) 1.2 (0.9–1.5) Total 1,208 17.0 (16.1–18.0) 1,003 14.1 (13.3–15.1) 1.2 (1.1–1.3) Abbreviations: CI = confidence interval; DSM-IV-TR = Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision; DSM-5 = Diagnostic and Statistical Manual of Mental Disorder, Fifth Edition. * Prevalence per 1,000 children aged 4 years living in the surveillance areas according to the vintage 2016 postcensal bridged-race population estimates for 2014 (http://www.cdc.gov/nchs). Results for PRs considered statistically significant when the CI excludes the null value (PR = 1.0). Site also reviewed records from early intervention sources. US Department of Health and Human Services/Centers for Disease Control and Prevention MMWR / April 12, 2019 / Vol. 68 / No. 2 19 The Morbidity and Mortality Weekly Report (MMWR) Series is prepared by the Centers for Disease Control and Prevention (CDC) and is available free of charge in electronic format. To receive an electronic copy each week, visit MMWR at https://www.cdc.gov/mmwr/index.html. Readers who have difficulty accessing this PDF file may access the HTML file at https://www.cdc.gov/mmwr/volumes/68/ss/ss6802a1.htm?s_ cid=ss6802a1_w. Address all inquiries about the MMWR Series, including material to be considered for publication, to Executive Editor, MMWR Series, Mailstop E-90, CDC, 1600 Clifton Rd., N.E., Atlanta, GA 30329-4027 or to mmwrq@cdc.gov. 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Published: Apr 12, 2019

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