Access the full text.
Sign up today, get DeepDyve free for 14 days.
N. Mochizuki, K. Matsumoto, Keiko Ohno, T. Shimamura, H. Furukawa, S. Todo, S. Kishino (2006)
Effects of hepatic CYP3A4 activity on disposition of micafungin in liver transplant recipients with markedly small-for-size grafts.Transplantation proceedings, 38 10
A. Ghaemmaghami, V. Aboyans, A. Morvarid (2015)
[Drug interactions].Journal of the Dental School, National University of Iran, 9 1
D. Nebert, D. Russell (2002)
Clinical importance of the cytochromes P450The Lancet, 360
(2010)
Development and validation of the quantitative determination of endogenous cortisol and 6-β – hydroxycortisol in urine in order to determine the activity of the CYP 3A4 isoenzyme
V. Shumyantseva, A. Makhova, T. Bulko, A. Kuzikov, E. Shich, V. Kukes, A. Archakov (2015)
Electrocatalytic cycle of P450 cytochromes: the protective and stimulating roles of antioxidantsRSC Advances, 5
Gaofeng Wu, Jiancheng Yang, Hao Lv, W. Jing, Jiaqi Zhou, Ying Feng, Shumei Lin, Qunhui Yang, Jianmin Hu (2018)
Taurine prevents ethanol-induced apoptosis mediated by mitochondrial or death receptor pathways in liver cellsAmino Acids, 50
W. Chiou, Hyunyoung Jeong, Ta-Chen Wu, Chien Ma (2001)
Use of the erythromycin breath test for in vivo assessments of cytochrome P4503A activity and dosage individualizationClinical Pharmacology & Therapeutics, 70
U. Lutz, Nataly Bittner, M. Ufer, W. Lutz (2010)
Quantification of cortisol and 6 beta-hydroxycortisol in human urine by LC-MS/MS, and gender-specific evaluation of the metabolic ratio as biomarker of CYP3A activity.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 878 1
M. Galteau, F. Shamsa (2003)
Urinary 6β-hydroxycortisol: a validated test for evaluating drug induction or drug inhibition mediated through CYP3A in humans and in animalsEuropean Journal of Clinical Pharmacology, 59
S. Sadeghi, S. Ferrero, Giovanna Nardo, G. Gilardi (2012)
Drug-drug interactions and cooperative effects detected in electrochemically driven human cytochrome P450 3A4.Bioelectrochemistry, 86
A. Hisaka, Y. Ohno, Takehito Yamamoto, H. Suzuki (2010)
Prediction of pharmacokinetic drug-drug interaction caused by changes in cytochrome P450 activity using in vivo information.Pharmacology & therapeutics, 125 2
V. Shumyantseva, A. Makhova, E. Shikh, T. Bulko, A. Kuzikov, R. Masamrekh, T. Shkel, S. Usanov, A. Gilep, A. Archakov (2018)
Bioelectrochemical Systems as Technologies for Studying Drug Interactions Related to Cytochrome P450BioNanoScience, 9
T. Brody (2018)
Drug–Drug Interactions: Part One (Small Molecule Drugs)
Zhang Hong, Fang Yu, Liu Ying, Liang Aibin (2010)
A highly sensitive SPE- liquid/liquid extraction – RPLC analytical method for the determination of 6β-hydroxycortisol and cortisol in cancer patients' urineJournal of Medical Colleges of Pla, 25
Ronny Frank, Marcus Klenner, Ronny Azendorf, Manuel Bartz, Heinz‐Georg Jahnke, A. Robitzki (2017)
Novel 96-well quantitative bioelectrocatalytic analysis platform reveals highly efficient direct electrode regeneration of cytochrome P450 BM3 on indium tin oxide.Biosensors & bioelectronics, 93
Y. Barrett, B. Akinsanya, Shu-Ying Chang, O. Vesterqvist (2005)
Automated on-line SPE LC-MS/MS method to quantitate 6beta-hydroxycortisol and cortisol in human urine: use of the 6beta-hydroxycortisol to cortisol ratio as an indicator of CYP3A4 activity.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 821 2
H. Matsuda, K. Kinoshita, A. Sumida, Koichi Takahashi, S. Fukuen, T. Fukuda, Kyoko Takahashi, I. Yamamoto, J. Azuma (2002)
Taurine modulates induction of cytochrome P450 3A4 mRNA by rifampicin in the HepG2 cell line.Biochimica et biophysica acta, 1593 1
J. Das, J. Ghosh, Prasenjit Manna, P. Sil (2008)
Taurine provides antioxidant defense against NaF-induced cytotoxicity in murine hepatocytes.Pathophysiology : the official journal of the International Society for Pathophysiology, 15 3
A. Rocha, E. Coelho, Soraia Moussa, V. Lanchote (2008)
Investigation of the in vivo activity of CYP3A in Brazilian volunteers: comparison of midazolam and omeprazole as drug markersEuropean Journal of Clinical Pharmacology, 64
Zaiqi Wang, J. Gorski, M. Hamman, Shiew-Mei Huang, L. Lesko, S. Hall (2001)
The effects of St John's wort (Hypericum perforatum) on human cytochrome P450 activityClinical Pharmacology & Therapeutics, 70
E. Sugiyama, Atsuko Kikuchi, M. Inada, Hitoshi Sato (2011)
The use of 13C-erythromycin as an in vivo probe to evaluate CYP3A-mediated drug interactions in rats.Journal of pharmaceutical sciences, 100 9
M. Letelier, José Jara-Sandoval, A. Molina-Berríos, M. Faúndez, P. Aracena-Parks, Felipe Aguilera (2010)
Melatonin protects the cytochrome P450 system through a novel antioxidant mechanism.Chemico-biological interactions, 185 3
V. Shumyantseva, T. Bulko, G. Kuznetsova, N. Samenkova, Alexander Archakov (2009)
Electrochemistry of cytochromes P450: Analysis of current-voltage characteristics of electrodes with immobilized cytochromes P450 for the screening of substrates and inhibitorsBiochemistry (Moscow), 74
(2013)
Regulation of the activity of drug metabolism enzymes – cytochromes P450 3A4 and 2C9 by biologically active compounds
F. Guengerich (2010)
Cytochrome P450 Enzymes, 4
T. Tateishi, M. Watanabe, H. Nakura, M. Asoh, H. Shirai, Y. Mizorogi, S. Kobayashi, K. Thummel, G. Wilkinson (2001)
CYP3A activity in European American and Japanese men using midazolam as an in vivo probeClinical Pharmacology & Therapeutics, 69
F. Guengerich, M. Waterman, M. Egli (2016)
Recent Structural Insights into Cytochrome P450 Function.Trends in pharmacological sciences, 37 8
J. Das, J. Ghosh, Prasenjit Manna, P. Sil (2010)
Taurine protects acetaminophen-induced oxidative damage in mice kidney through APAP urinary excretion and CYP2E1 inactivation.Toxicology, 269 1
A. Veith, B. Moorthy (2018)
ROLE OF CYTOCHROME P450S IN THE GENERATION AND METABOLISM OF REACTIVE OXYGEN SPECIES.Current opinion in toxicology, 7
A. Makhova, V. Shumyantseva, E. Shich, T. Bulko, V. Kukes, O. Sizova, G. Ramenskaya, S. Usanov, A. Archakov (2011)
Electroanalysis of Cytochrome P450 3A4 Catalytic Properties with Nanostructured Electrodes: The Influence of Vitamin B Group on Diclofenac MetabolismBioNanoScience, 1
Lei Zhang, K. Reynolds, P. Zhao, Shiew-Mei Huang (2010)
Drug interactions evaluation: an integrated part of risk assessment of therapeutics.Toxicology and applied pharmacology, 243 2
Zhoupeng Zhang, Wei Tang (2018)
Drug metabolism in drug discovery and developmentActa Pharmaceutica Sinica. B, 8
Hussain Alquraini, R. Auchus (2017)
Strategies that athletes use to avoid detection of androgenic-anabolic steroid doping and sanctionsMolecular and Cellular Endocrinology, 464
Ted Ashburn, K. Thor (2004)
Drug repositioning: identifying and developing new uses for existing drugsNature Reviews Drug Discovery, 3
Matthew Albertolle, F. Guengerich (2018)
The relationships between cytochromes P450 and H2O2: Production, reaction, and inhibition.Journal of inorganic biochemistry, 186
V. Shumyantseva, A. Makhova, T. Bulko, R. Bernhardt, A. Kuzikov, E. Shich, V. Kukes, A. Archakov (2015)
Taurine modulates catalytic activity of cytochrome P450 3A4Biochemistry (Moscow), 80
Sonia Zambrano, A. Blanca, M. Ruiz-Armenta, J. Miguel-Carrasco, M. Arévalo, M. Vazquez, A. Mate, C. Vázquez (2013)
L-Carnitine protects against arterial hypertension-related cardiac fibrosis through modulation of PPAR-γ expression.Biochemical pharmacology, 85 7
AbstractBackgroundCytochrome P450s (CYPs, EC 1.14.14.1) are the main enzymes of drug metabolism. The functional significance of CYPs also includes the metabolism of foreign chemicals and endogenic biologically active compounds. The CYP3A4 isoform contributes to the metabolism of about half of all marketed medicinal preparations. The aim of this study was to investigate the effects of two biologically active compounds: 2-aminoethane-sulfonic acid (taurine) and 3-hydroxy-4-trimethylaminobutyrate (L-carnitine) on urinary 6β-hydroxycortisol/cortisol (6β-OHC/cortisol) metabolic ratio as a biomarker of the CYP3A4 activity of healthy volunteers. Taurine is used for the treatment of chronic heart failure and liver disease. Cardiologists, nephrologists, neurologists, gerontologists in addition to the main etiopathogenetic therapies, use L-carnitine. The quantification of the 6β-OHC/cortisol metabolic ratio as a biomarker of CYP3A4 activity in human urine was used for the assessment of CYP3A4 catalytic activity as a non-invasive test.MethodsThe study included 18 healthy male volunteers (aged from 18 to 35 years old). The volunteers took taurine in a dose of 500 mg twice a day or L-carnitine in a dose of 2.5 mL 3 times a day for 14 consecutive days. The test drug was given 20 min before meals. The collection of urine samples was performed before and after 3, 7, 10, and 14 days after taurine intake. The metabolic ratio of 6β-OHC/cortisol in morning spot urine samples was studied by the liquid chromatography/mass spectroscopy (LC/MS) method.ResultsThe ratio of 6-6β-OHC/cortisol was used as a biomarker to study the taurine and L-carnitine influence on CYP3A4 metabolism of cortisol. The ratio of urinary 6β-OCH/cortisol in the morning urine samples of volunteers before the beginning of taurine therapy (baseline ratio) was 2.71 ± 0.2. Seven days after the administration of taurine in a dose of 500 mg twice a day, the 6β-OCH/cortisol ratio was 3.3 ± 0.2, which indicated the increased catalytic activity of CYP3A4 towards cortisol. As for the L-carnitine supplementation, analysis of the 6β-OCH/cortisol ratio in the urine for 14 days did not show any significant changes in this baseline ratio, indicating the lack of L-carnitine influence on the catalytic activity of CYP3A4 to cortisol.ConclusionsThe results obtained demonstrated the influence of taurine on 6β-OCH/cortisol metabolic ratio as a biomarker of CYP3A4 catalytic activity to cortisol. L-carnitine did not affect the activity of CYP3A4. The lack of a clinically meaningful effect of L-carnitine was established.
Drug Metabolism and Drug Interactions – de Gruyter
Published: Sep 25, 2019
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.