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Introduction Curriculum vitae RAGNHILD HJERTBERG, M.D., was graduated from Uppsala University in 1979 and qualified as a specialist in Obstetrics and Gynecology in 1988. Since 1982 she has worked at the Department of Obstetrics and Gynecology, Karolinska Hospital and Karolinska Institute, Stockholm, Sweden, and is a member of the staff since 1991. Hypertension in pregnancy affects about 5% of all pregnant women [6] in a Swedish population. In this group there is a high maternal and fetal morbidity. The policy regarding how, when, and with what antihypertensive drug these patients should be treated, has been a matter of debate [2, 21]. In Sweden, the most common drug to treat hypertension in pregnancy has been hydralazine until the 80s. In the last decade, betablockers and the combined alpha- and betablocker labetalol have come into increasing use [13]. Hydralazine is a mild vasodilator with a wide range of interindividual dose response [18]. It has a negative effect on uteroplacental circulation, especially when the patient does not respond with a prompt blood pressure reduction [19]. Labetalol is a non-selective betablocker and a post-synaptic alpha-1 blocking agent. It decreases systemic vascular resistance with little or no change in cardiac output. It has
Journal of Perinatal Medicine – de Gruyter
Published: Jan 1, 1993
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