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The IgG avidity value for the prediction of congenital cytomegalovirus infection in a prospective cohort study

The IgG avidity value for the prediction of congenital cytomegalovirus infection in a prospective... Abstract Background: Cytomegalovirus (CMV) causes congenital infection with high mortality and morbidity rates in affected neonates. Objectives: To evaluate the maternal IgG avidity value for the prediction of congenital CMV infection. Study design: The serum IgG avidity in all mothers was measured, and the urine of their neonates was assessed for CMV DNA in a prospective cohort study. Results: Of 759 women with a positive test for CMV IgG, 14 had congenital CMV infection. CMV IgG avidity indices in the congenital infection group (median 35.1%) were significantly lower than those in the non-congenital infection group (70.4%). A cutoff value of <40% IgG avidity index with 96.1% specificity and 64.3% sensitivity for congenital infection was determined by receiver operating characteristic curve analyses. The highest sensitivity (88.9%), 96.2% specificity, 27.6% positive predictive value, 99.8% negative predictive value, and 96.1% accuracy were found when IgG avidity was measured in <28 weeks of gestation. Conclusion: The IgG avidity measurement with a cutoff value of <40% IgG avidity index might be helpful in predicting congenital CMV infection, especially in <28 weeks of gestation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Perinatal Medicine de Gruyter

The IgG avidity value for the prediction of congenital cytomegalovirus infection in a prospective cohort study

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Publisher
de Gruyter
Copyright
Copyright © 2014 by the
ISSN
0300-5577
eISSN
1619-3997
DOI
10.1515/jpm-2013-0333
pmid
24663226
Publisher site
See Article on Publisher Site

Abstract

Abstract Background: Cytomegalovirus (CMV) causes congenital infection with high mortality and morbidity rates in affected neonates. Objectives: To evaluate the maternal IgG avidity value for the prediction of congenital CMV infection. Study design: The serum IgG avidity in all mothers was measured, and the urine of their neonates was assessed for CMV DNA in a prospective cohort study. Results: Of 759 women with a positive test for CMV IgG, 14 had congenital CMV infection. CMV IgG avidity indices in the congenital infection group (median 35.1%) were significantly lower than those in the non-congenital infection group (70.4%). A cutoff value of <40% IgG avidity index with 96.1% specificity and 64.3% sensitivity for congenital infection was determined by receiver operating characteristic curve analyses. The highest sensitivity (88.9%), 96.2% specificity, 27.6% positive predictive value, 99.8% negative predictive value, and 96.1% accuracy were found when IgG avidity was measured in <28 weeks of gestation. Conclusion: The IgG avidity measurement with a cutoff value of <40% IgG avidity index might be helpful in predicting congenital CMV infection, especially in <28 weeks of gestation.

Journal

Journal of Perinatal Medicine – de Gruyter

Published: Nov 1, 2014

References

  • Screening for congenital cytomegalovirus infection using newborn urine samples collected on filter paper : feasibility and outcomes from a multicentre study Open
    Koyano
  • Differentiation of primary cytomegalovirus infection from reactivation using the urea denaturation test for measuring antibody avidity
    Blackburn
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    Lazzarotto
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    Bodeus
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    Lazzarotto
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    Tagawa
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    Lazzarotto
  • Value of cytomegalovirus avidity index for the diagnosis of primary CMV infection in pregnant women
    Grangeot
  • Screening for congenital cytomegalovirus infection using newborn urine samples collected on filter paper : feasibility and outcomes from a multicentre study Open
    Koyano
  • ME RE EG Congenital cytomegalovirus infection : the relative importance of primary and recurrent maternal infection
    Stagno
  • Herpesvirus infections of pregnancy Part cytomegalovirus virus infections
    Stagno
  • The value of CMV IgG avidity and immunoblot for timing the onset of primary CMV infection in pregnancy
    Enders
  • Low IgG avidity and ultrasound fetal abnormality predict congenital cytomegalovirus infection
    Sonoyama
  • ME RE EG Congenital cytomegalovirus infection : the relative importance of primary and recurrent maternal infection
    Stagno
  • The value of CMV IgG avidity and immunoblot for timing the onset of primary CMV infection in pregnancy
    Enders
  • Value of cytomegalovirus avidity index for the diagnosis of primary CMV infection in pregnant women
    Grangeot
  • Maternal IgG avidity and IgM detected by blot as diagnostic tools to identify pregnant women at risk of transmitting cytomegalovirus
    Lazzarotto
  • Low IgG avidity and ultrasound fetal abnormality predict congenital cytomegalovirus infection
    Sonoyama
  • Maternal IgG avidity and IgM detected by blot as diagnostic tools to identify pregnant women at risk of transmitting cytomegalovirus
    Lazzarotto
  • Avidity of IgG antibodies distinguishes primary from non - primary cytomegalovirus infection in pregnant women
    Bodeus
  • Avidity of immunoglobulin G directed against human cytomegalovirus during primary and secondary infections in immunocompetent and immunocompromised subjects
    Lazzarotto
  • Differentiation of primary cytomegalovirus infection from reactivation using the urea denaturation test for measuring antibody avidity
    Blackburn