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Glutamine and Glutamate in Ascitic Fluid of Dogs

Glutamine and Glutamate in Ascitic Fluid of Dogs Hirschberger et al.: Glutamine and glutamate in ascitic fluid of dogs Eur. J. Clin. Chem. Clin. Biochem. Vol.31, 1993, pp. 103-106 © 1993 Walter de Gruyter & Co. Berlin · New York By J. Hirschberger1, M. Goldberg2 and Ursula G. Sauer1 L Medizinische Tierklinik Institut f r Tierphysiologie University of Munich, Federal Republic of Germany (Received March 26/October 18, 1992) Summary: The amino acid pattern in the ascites of 79 dogs was examined. The concentration of glutamine in neoplastic ascites is significantly lower than in cardial effusions. In contrast, glutamate is significantly higher in neoplastic ascites than in cardial ascites. Using an arbitrary discrimination value of 0.28 for the glutamate/glutamine ratio, purulent or cardial ascites are easily differentiated, with a sensitivity of 100% and a specificity of 94%. The differentiation is very distinct, with no overlap between the group of patients with liver cirrhosis on the one hand and the groups of patients with purulent peritonitis, heart failure, or malignant ascites on the other hand. There was no diagnostically usable correlation between the concentrations of the other 20 amino acids and the underlying causes of ascites formation. Introduction The examination of body effusions contributes to the aetiological diagnosis http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Chemistry and Laboratory Medicine de Gruyter

Glutamine and Glutamate in Ascitic Fluid of Dogs

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References (13)

Publisher
de Gruyter
Copyright
Copyright © 2009 Walter de Gruyter
ISSN
1434-6621
eISSN
1437-4331
DOI
10.1515/cclm.1993.31.2.103
Publisher site
See Article on Publisher Site

Abstract

Hirschberger et al.: Glutamine and glutamate in ascitic fluid of dogs Eur. J. Clin. Chem. Clin. Biochem. Vol.31, 1993, pp. 103-106 © 1993 Walter de Gruyter & Co. Berlin · New York By J. Hirschberger1, M. Goldberg2 and Ursula G. Sauer1 L Medizinische Tierklinik Institut f r Tierphysiologie University of Munich, Federal Republic of Germany (Received March 26/October 18, 1992) Summary: The amino acid pattern in the ascites of 79 dogs was examined. The concentration of glutamine in neoplastic ascites is significantly lower than in cardial effusions. In contrast, glutamate is significantly higher in neoplastic ascites than in cardial ascites. Using an arbitrary discrimination value of 0.28 for the glutamate/glutamine ratio, purulent or cardial ascites are easily differentiated, with a sensitivity of 100% and a specificity of 94%. The differentiation is very distinct, with no overlap between the group of patients with liver cirrhosis on the one hand and the groups of patients with purulent peritonitis, heart failure, or malignant ascites on the other hand. There was no diagnostically usable correlation between the concentrations of the other 20 amino acids and the underlying causes of ascites formation. Introduction The examination of body effusions contributes to the aetiological diagnosis

Journal

Clinical Chemistry and Laboratory Medicinede Gruyter

Published: Jan 1, 1993

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