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Klinisch-chemische Untersuchung von Körperhöhlenergüsseri. Tierärztl
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Hirschberger et al.: Glutamine and glutamate in ascitic fluid of dogs Eur. J. Clin. Chem. Clin. Biochem. Vol.31, 1993, pp. 103-106 © 1993 Walter de Gruyter & Co. Berlin · New York By J. Hirschberger1, M. Goldberg2 and Ursula G. Sauer1 L Medizinische Tierklinik Institut f r Tierphysiologie University of Munich, Federal Republic of Germany (Received March 26/October 18, 1992) Summary: The amino acid pattern in the ascites of 79 dogs was examined. The concentration of glutamine in neoplastic ascites is significantly lower than in cardial effusions. In contrast, glutamate is significantly higher in neoplastic ascites than in cardial ascites. Using an arbitrary discrimination value of 0.28 for the glutamate/glutamine ratio, purulent or cardial ascites are easily differentiated, with a sensitivity of 100% and a specificity of 94%. The differentiation is very distinct, with no overlap between the group of patients with liver cirrhosis on the one hand and the groups of patients with purulent peritonitis, heart failure, or malignant ascites on the other hand. There was no diagnostically usable correlation between the concentrations of the other 20 amino acids and the underlying causes of ascites formation. Introduction The examination of body effusions contributes to the aetiological diagnosis
Clinical Chemistry and Laboratory Medicine – de Gruyter
Published: Jan 1, 1993
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