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Introduction The clinical and forensic laboratory is responsible for providing results which are as precise and accurate as possible (1 --2). It is generally accepted that two methods, an oxido-reductimetric and a gas Chromatographie method for the determination of blood ethanol concentration, are statuary in forensic practice (3--4). Gas chromatography is generally recommended for identification and quantitation of volatile polar organic compounds such as ethanol in body fluids (5--6). Different Chromatographie strategies for blood ethanol determination can be adopted for clinical and forensic purposes (7). Sampling techniques include headspace analysis (8 -- 10), liquid-liquid extractions and direct injection of body fluids. If both blood and urine samples are to be analysed, the direct injection of diluted plasma samples, which minimizes sample handling and allows rapid feedback of data, is preferred (11 -- 12). Syringe blockage can be minimized by using removable needles or by washing the syringe. The injection port must be regularly cleaned of residues from biological samples. Eiir. J. Clin. Chem. Clin. Biochem. / Vol. 31,1993 / No. 11 Quality assurance has become an essential element of clinical and forensic science. All aspects of performance should be monitored to ensure that the highest possible standards are
Clinical Chemistry and Laboratory Medicine – de Gruyter
Published: Jan 1, 1993
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