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The importance of angiogenic markers in the differential diagnosis of HELLP syndrome vs. non-HELLP thrombocytopenia

The importance of angiogenic markers in the differential diagnosis of HELLP syndrome vs.... Clin Chem Lab Med 2016; 54(7): e187­e189 Letter to the Editor Covadonga Quirós, Francisco Suárez, Belén Prieto, Verónica Rodriguez, Óscar Vaquerizo and Francisco V. Álvarez Menéndez* DOI 10.1515/cclm-2015-0890 Received September 12, 2015; accepted October 15, 2015; previously published online November 18, 2015 Keywords: HELLP syndrome; PlGF; preeclampsia; sFlt-1; thrombocytopenia. To the Editor, The diagnosis of HELLP syndrome requires the presence of hemolysis (elevated unconjugated bilirubin, low serum haptoglobin or elevated lactate dehydrogenase concentrations) in association with significant increased liver enzymes and a platelet count below 100,000/mm3 , after ruling out other causes of hemolysis and thrombocytopenia [1, 2]. Deciding whether HELLP syndrome is a severe form of preeclampsia (PE) or not, is controversial [3]. The majority of patients with HELLP syndrome develop PE; however, approximately 10%­20% of them do not show any signs of hypertension and/or proteinuria. Moreover, laboratory findings in HELLP syndrome usually do not correlate with the severity of hypertension or proteinuria. PE typically develops gradually while the onset of HELLP syndrome is frequently rapid [1, 2, 4]. There are women who attend the emergency department for a preeclampsia evaluation with low platelet count secondary to either gestational thrombocytopenia or immune thrombocytopenic purpura (ITP) or manifest http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Chemistry and Laboratory Medicine (CCLM) de Gruyter

The importance of angiogenic markers in the differential diagnosis of HELLP syndrome vs. non-HELLP thrombocytopenia

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References (13)

Publisher
de Gruyter
Copyright
Copyright © 2016 by the
ISSN
1434-6621
eISSN
1437-4331
DOI
10.1515/cclm-2015-0890
pmid
26581071
Publisher site
See Article on Publisher Site

Abstract

Clin Chem Lab Med 2016; 54(7): e187­e189 Letter to the Editor Covadonga Quirós, Francisco Suárez, Belén Prieto, Verónica Rodriguez, Óscar Vaquerizo and Francisco V. Álvarez Menéndez* DOI 10.1515/cclm-2015-0890 Received September 12, 2015; accepted October 15, 2015; previously published online November 18, 2015 Keywords: HELLP syndrome; PlGF; preeclampsia; sFlt-1; thrombocytopenia. To the Editor, The diagnosis of HELLP syndrome requires the presence of hemolysis (elevated unconjugated bilirubin, low serum haptoglobin or elevated lactate dehydrogenase concentrations) in association with significant increased liver enzymes and a platelet count below 100,000/mm3 , after ruling out other causes of hemolysis and thrombocytopenia [1, 2]. Deciding whether HELLP syndrome is a severe form of preeclampsia (PE) or not, is controversial [3]. The majority of patients with HELLP syndrome develop PE; however, approximately 10%­20% of them do not show any signs of hypertension and/or proteinuria. Moreover, laboratory findings in HELLP syndrome usually do not correlate with the severity of hypertension or proteinuria. PE typically develops gradually while the onset of HELLP syndrome is frequently rapid [1, 2, 4]. There are women who attend the emergency department for a preeclampsia evaluation with low platelet count secondary to either gestational thrombocytopenia or immune thrombocytopenic purpura (ITP) or manifest

Journal

Clinical Chemistry and Laboratory Medicine (CCLM)de Gruyter

Published: Jul 1, 2016

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