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The Third International Symposium on Microsomes and Drug Oxidations

The Third International Symposium on Microsomes and Drug Oxidations Hoppe-Seyler's Z. Physiol. Chem. Bd. 357, S. 1019 - 1067, August 1976 July 21 - 24, 1976 in Berlin (Klinikum Steglitz) Organized by A.H. Conney (Nutley, N.J.), R.W. Estabrook (Dallas, Tex.), A.G. Hildebrandt (Berlin), V. Ullrich (Homburg/Saar) on behalf of the Gesellschaft für Biologische Chemie Sponsored by Stiftung Volkswagenwerk, Paul Martini-Stiftung and Freie Universität Berlin Abstracts J. Ahokas, R. Pääkkönen, K. Rönnholm, V. Raunio and 0. Pelkonen Oxidative Metabolism of Carcinogens by Trout Liver Resulting in Protein Binding and Mutagenicity Trout liver has high benzo(o)pyrene hydroxylase activity and it is well known that trout are prone to develop hepatoma as a result of exposure to some environmental or food contaminants. In the light of modern views on chemical carcinogenesis these two facts may be very closely related to each other. In this study protein binding resulting from metabolic activation by trout liver microsomes was investigated. The substrate used was [3H]benzo(o)pyrene and under the conditions used 23% of the metabolites produced were water soluble, 66% ethyl acetate soluble and 11 % were covalently bound to protein. The active intermediate binding to protein is very likely an epoxide, consequently an accumulation of epoxides in the incubation medium should result in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png hoppe-seyler's zeitschrift für physiologische chemie de Gruyter

The Third International Symposium on Microsomes and Drug Oxidations

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Publisher
de Gruyter
Copyright
Copyright © 1976 by the
ISSN
0018-4888
eISSN
1437-4315
DOI
10.1515/bchm2.1976.357.2.1019
Publisher site
See Article on Publisher Site

Abstract

Hoppe-Seyler's Z. Physiol. Chem. Bd. 357, S. 1019 - 1067, August 1976 July 21 - 24, 1976 in Berlin (Klinikum Steglitz) Organized by A.H. Conney (Nutley, N.J.), R.W. Estabrook (Dallas, Tex.), A.G. Hildebrandt (Berlin), V. Ullrich (Homburg/Saar) on behalf of the Gesellschaft für Biologische Chemie Sponsored by Stiftung Volkswagenwerk, Paul Martini-Stiftung and Freie Universität Berlin Abstracts J. Ahokas, R. Pääkkönen, K. Rönnholm, V. Raunio and 0. Pelkonen Oxidative Metabolism of Carcinogens by Trout Liver Resulting in Protein Binding and Mutagenicity Trout liver has high benzo(o)pyrene hydroxylase activity and it is well known that trout are prone to develop hepatoma as a result of exposure to some environmental or food contaminants. In the light of modern views on chemical carcinogenesis these two facts may be very closely related to each other. In this study protein binding resulting from metabolic activation by trout liver microsomes was investigated. The substrate used was [3H]benzo(o)pyrene and under the conditions used 23% of the metabolites produced were water soluble, 66% ethyl acetate soluble and 11 % were covalently bound to protein. The active intermediate binding to protein is very likely an epoxide, consequently an accumulation of epoxides in the incubation medium should result in

Journal

hoppe-seyler's zeitschrift für physiologische chemiede Gruyter

Published: Jan 1, 1976

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