Access the full text.
Sign up today, get DeepDyve free for 14 days.
L. Zuo, S. Ge, Yuanyuan Ge, Jingjing Li, B. Zhu, Zongbing Zhang, C. Jiang, Jing Li, Su-jun Wang, Mulin Liu, Shiqing Li, Rong Wu, Jianguo Hu (2019)
The adipokine metrnl ameliorates chronic colitis in Il-10-/- mice by attenuating mesenteric adipose tissue lesions during spontaneous colitis.Journal of Crohn's & colitis
Rajesh Rao, J. Long, James White, Katrin Svensson, Jesse Lou, Isha Lokurkar, Mark Jedrychowski, J. Ruas, C. Wrann, J. Lo, D. Camera, J. Lachey, S. Gygi, J. Seehra, J. Hawley, B. Spiegelman (2014)
Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat ThermogenesisCell, 157
Zhuofeng Lin, Haishan Tian, K. Lam, Shao-qiang Lin, R. Hoo, M. Konishi, N. Itoh, Yu Wang, S. Bornstein, A. Xu, Xiaokun Li (2013)
Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice.Cell metabolism, 17 5
(2006)
Definition and diagnosis of diabetes mellitus and intermediate hyperglycaemia
H. Chung, K. Choi (2017)
Adipokines and Myokines: A Pivotal Role in Metabolic and Cardiovascular Disorders.Current medicinal chemistry, 25 20
P. Boström, Jun Wu, Mark Jedrychowski, Anisha Korde, L. Ye, J. Lo, K. Rasbach, E. Boström, J. Choi, J. Long, S. Kajimura, M. Zingaretti, B. Vind, H. Tu, S. Cinti, K. Højlund, S. Gygi, B. Spiegelman (2012)
A PGC1α-dependent myokine that drives browning of white fat and thermogenesisNature, 481
J. Lee, Y. Kang, Ji Kim, S. Choung, K. Joung, Hyun Kim, B. Ku (2018)
Serum Meteorin-like protein levels decreased in patients newly diagnosed with type 2 diabetes.Diabetes research and clinical practice, 135
Andrew Johnson, J. Olefsky (2013)
The Origins and Drivers of Insulin ResistanceCell, 152
Si-Li Zheng, Zhi-yong Li, Zheng Zhang, Dong-sheng Wang, Jian Xu, C. Miao (2018)
Evaluation of Two Commercial Enzyme-Linked Immunosorbent Assay Kits for the Detection of Human Circulating Metrnl.Chemical & pharmaceutical bulletin, 66 4
Zhi-yong Li, Si-Li Zheng, Pei Wang, Tian-ying Xu, Yun-feng Guan, Yi-Jie Zhang, C. Miao (2014)
Subfatin is a Novel Adipokine and Unlike Meteorin in Adipose and Brain ExpressionCNS Neuroscience & Therapeutics, 20
M. Saghebjoo, Afsaneh Einaloo, M. Mogharnasi, Fereshteh Ahmadabadi (2018)
The response of meteorin-like hormone and interleukin-4 in overweight women during exercise in temperate, warm and cold waterHormone Molecular Biology and Clinical Investigation, 36
A. Levey, L. Stevens, C. Schmid, Y. Zhang, Alejandro Castro, H. Feldman, J. Kusek, P. Eggers, F. Lente, T. Greene, J. Coresh (2009)
A new equation to estimate glomerular filtration rate.Annals of internal medicine, 150 9
S. Gray, E. Nora, J. Grosse, M. Manieri, T. Stoeger, G. Medina-Gómez, K. Burling, S. Wattler, A. Russ, G. Yeo, V. Chatterjee, S. O’Rahilly, P. Voshol, S. Cinti, A. Vidal-Puig (2006)
Leptin deficiency unmasks the deleterious effects of impaired peroxisome proliferator-activated receptor gamma function (P465L PPARgamma) in mice.Diabetes, 55 10
H. Chung, S. Hwang, Ju-Hee Choi, H. Lee, N. Kim, H. Yoo, J. Seo, S. Kim, N. Kim, S. Baik, K. Choi (2018)
Implications of circulating Meteorin-like (Metrnl) level in human subjects with type 2 diabetes.Diabetes research and clinical practice, 136
R. Ahima, M. Lazar (2013)
The Health Risk of Obesity—Better Metrics ImperativeScience, 341
S. Gray, E. Nora, J. Grosse, M. Manieri, T. Stoeger, G. Medina-Gómez, K. Burling, S. Wattler, A. Russ, G. Yeo, V. Chatterjee, S. O’Rahilly, P. Voshol, S. Cinti, A. Vidal-Puig (2006)
Leptin Deficiency Unmasks the Deleterious Effects of Impaired Peroxisome Proliferator–Activated Receptor γ Function (P465L PPARγ) in MiceDiabetes, 55
D. Akram, A. Astrup, T. Atinmo, J. Boissin, G. Bray, K. Carroll, P. Chitson, C. Chunming, W. Dietz, James Hill, E. Jéquier, C. Komodiki, Y. Matsuzawa, W. Mollentze, K. Moosa, M. Noor, K. Reddy, J. Seidell, V. Tanphaichitr, R. Uauy, P. Zimmet (2000)
Obesity : Preventing and managing the global epidemic
D. Löffler, K. Landgraf, D. Rockstroh, J. Schwartze, H. Dunzendorfer, W. Kiess, A. Körner (2017)
METRNL decreases during adipogenesis and inhibits adipocyte differentiation leading to adipocyte hypertrophy in humansInternational Journal of Obesity, 41
T. Jung, Sung Lee, Hyoung‐Chun Kim, J. Bang, A. El-Aty, A. Hacımüftüoğlu, Y. Shin, J. Jeong (2018)
METRNL attenuates lipid-induced inflammation and insulin resistance via AMPK or PPARδ-dependent pathways in skeletal muscle of miceExperimental & Molecular Medicine, 50
A. Tso, A. Xu, P. Sham, N. Wat, Yu Wang, C. Fong, B. Cheung, E. Janus, K. Lam (2007)
Serum Adipocyte Fatty Acid–Binding Protein as a New Biomarker Predicting the Development of Type 2 DiabetesDiabetes Care, 30
B. Pedersen (2007)
IL-6 signalling in exercise and disease.Biochemical Society transactions, 35 Pt 5
Malcolm Eaton, C. Granata, J. Barry, A. Safdar, D. Bishop, J. Little (2017)
Impact of a single bout of high-intensity interval exercise and short-term interval training on interleukin-6, FNDC5, and METRNL mRNA expression in human skeletal muscleJournal of Sport and Health Science, 7
A. Pfützner, M. Weber, T. Forst (2008)
A biomarker concept for assessment of insulin resistance, beta-cell function and chronic systemic inflammation in type 2 diabetes mellitus.Clinical laboratory, 54 11-12
Zhi-yong Li, Jie Song, Si-Li Zheng, Mao-bing Fan, Yun-feng Guan, Y. Qu, Jian Xu, Pei Wang, C. Miao (2015)
Adipocyte Metrnl Antagonizes Insulin Resistance Through PPARγ SignalingDiabetes, 64
Irina Ushach, Gerardo Arrevillaga-Boni, Gina Heller, E. Pone, M. Hernández-Ruiz, Jovani Catalan-Dibene, P. Hevezi, A. Zlotnik (2018)
Meteorin-like/Meteorin-β Is a Novel Immunoregulatory Cytokine Associated with InflammationThe Journal of Immunology, 201
Si-Li Zheng, Zhi-yong Li, Jie Song, Jian-min Liu, C. Miao (2016)
Metrnl: a secreted protein with new emerging functionsActa Pharmacologica Sinica, 37
Shanshan Li, H. Shin, E. Ding, R. Dam (2009)
Adiponectin levels and risk of type 2 diabetes: a systematic review and meta-analysis.JAMA, 302 2
BackgroundMeteorin-like (Metrnl) is a novel adipomyokine that may improve glucose tolerance and affect insulin resistance. This study aimed to investigate the association between serum levels of Metrnl with blood glucose status and to its association with insulin resistance.Material/MethodsThe study included 160 subjects with normal glucose tolerance (NGT) (n=40), impaired fasting glucose (IFG) (n=40), impaired glucose tolerance (IGT) (n=40), and newly diagnosed type 2 diabetes mellitus (T2DM) (n=40). An enzyme-linked immunosorbent assay (ELISA) was used to measure the serum levels of Metrnl. Partial correlation analysis was used to analyze the relationship between serum levels of Metrnl and metabolic parameters. Multiple logistic regression analysis was performed to identify the association between serum levels of Metrnl with the risk of diabetes.ResultsSerum levels of Metrnl was highest in patients with T2DM and significantly increased in patients with prediabetes compared with individuals with NGT. After adjusting for age, gender, and body mass index (BMI), serum Metrnl level was significantly correlated with lipid profile, glucose profile, and insulin resistance. Multiple logistic regression analysis showed that Metrnl significantly increased the risk of T2DM (OR=1.727; P=0.008) before adjusting for the homeostatic model assessment of insulin resistance (HOMA-IR). When further adjusted for HOMA-IR, Metrnl was no longer associated with an increased OR for T2DM (OR=1.491; P=0.066), while the HOMA-IR significantly increased the risk of T2DM (OR=1.935; P=0.008).ConclusionsSerum levels of Metrnl were significantly increased in patients with T2DM and may increase the risk of T2DM independent of insulin resistance.
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research – Pubmed Central
Published: Mar 31, 2019
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.