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E THE OPEN MIND Richard K. Barnes, FANZCA See Articles, p 720 and 723 GLOSSARY ADHD = attention deficit hyperactivity disorder; FDA = Food and Drug Administration; GABA = γ-aminobutyric acid ; GAS = General Anaesthesia and Awake-regional Anaesthesia in A A Infancy; IARS = International Anesthesia Research Society; IQ = intelligence quotient; MASK = Mayo Anesthesia Safety in Kids; NHP = nonhuman primate; NMDA = N-methyl-d-aspartate; PANDA = Pediatric Anesthesia Neurodevelopment Assessment; TGA = Australian Therapeutic Goods Administration n 1981, a startling article was published in Anesthesia antagonist and γ-aminobutyric acid (GABA ) agonist A A & Analgesia: “Exposure to Halothane and Enflurane anesthetic agents causes both neuroapoptosis and signifi- IAffects Learning Function of Murine Progeny.” The cant memory impairment and behavioral changes. study found that adolescent mice that had been exposed Pediatric anesthetists now faced a troubling dilemma. in utero to halothane or enflurane anesthesia had mark- How could we reconcile the compelling animal evidence edly impaired maze learning compared with unexposed of harm, with over a century of apparently harmless anes- controls. Decades before the discovery of epigenetics, the thetic administration to children? Given the impossibility of article even showed that, in some cases, impairments were
Anesthesia & Analgesia – Wolters Kluwer Health
Published: Sep 5, 2020
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