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W. Ning, Yingying Dong, Jingxia Sun, Chaojun Li, M. Matthay, C. Feghali-Bostwick, A. Choi (2007)
Cigarette smoke stimulates matrix metalloproteinase-2 activity via EGR-1 in human lung fibroblasts.American journal of respiratory cell and molecular biology, 36 4
B. Barikbin, S. Givrad, M. Yousefi, F. Eskandari (2009)
Pimecrolimus 1% cream versus betamethasone 17‐valerate 0.1% cream in the treatment of facial discoid lupus erythematosus: a double‐blind, randomized pilot studyClinical and Experimental Dermatology, 34
Roenigk Hh, Martin Js, P. Eichorn, Gilliam Jn (1980)
Discoid lupus erythematosus. Diagnostic features and evaluation of topical corticosteroid therapy.Cutis, 25 3
P. Panopalis, J. Yazdany, J. Gillis, L. Julian, L. Trupin, A. Hersh, L. Criswell, P. Katz, E. Yelin (2008)
Health care costs and costs associated with changes in work productivity among persons with systemic lupus erythematosus.Arthritis and rheumatism, 59 12
J. Hui-Yuen, A. Reddy, Jennifer Taylor, Xiaoqing Li, A. Eichenfield, Liza Bermudez, A. Starr, L. Imundo, J. Buyon, R. Furie, D. Kamen, S. Manzi, M. Petri, R. Ramsey‐Goldman, R. Vollenhoven, D. Wallace, A. Askanase (2015)
Safety and Efficacy of Belimumab to Treat Systemic Lupus Erythematosus in Academic Clinical PracticesThe Journal of Rheumatology, 42
C. Drenkard, G. Bao, G. Dennis, H. Kan, P. Jhingran, C. Molta, S. Lim (2014)
Burden of Systemic Lupus Erythematosus on Employment and Work Productivity: Data From a Large Cohort in the Southeastern United StatesArthritis Care & Research, 66
A. Ugarte, S. Porta, R. Ríos, A. Martínez-zapico, N. Ortego-Centeno, N. Agesta, G. Ruiz‐Irastorza (2018)
Combined mepacrine–hydroxychloroquine treatment in patients with systemic lupus erythematosus and refractory cutaneous and articular activityLupus, 27
A. Kuhn, A. Kuhn, Johanna Sigges, Cyrus Biazar, V. Ruland, N. Patsinakidis, A. Landmann, S. Amler, G. Bonsmann (2014)
Influence of smoking on disease severity and antimalarial therapy in cutaneous lupus erythematosus: analysis of 1002 patients from the EUSCLE databaseBritish Journal of Dermatology, 171
F. Chasset, L. Arnaud, N. Costedoat-Chalumeau, N. Zahr, D. Bessis, C. Francès (2016)
The effect of increasing the dose of hydroxychloroquine (HCQ) in patients with refractory cutaneous lupus erythematosus (CLE): An open-label prospective pilot study.Journal of the American Academy of Dermatology, 74 4
Fnu Nutan, A. Ortega‐Loayza (2017)
Cutaneous Lupus: A Brief Review of Old and New Medical Therapeutic Options.The journal of investigative dermatology. Symposium proceedings, 18 2
JK Presto, EZ Hejazi, V. Werth (2017)
Biological therapies in the treatment of cutaneous lupus erythematosusLupus, 26
F. Chasset, J. Bouaziz, N. Costedoat-Chalumeau, C. Francès, L. Arnaud (2017)
Efficacy and comparison of antimalarials in cutaneous lupus erythematosus subtypes: a systematic review and meta‐analysisBritish Journal of Dermatology, 177
N. Costedoat-Chalumeau, Z. Amoura, J. Hulot, G. Aymard, G. Leroux, D. Marra, P. Lechat, J. Piette (2007)
Very low blood hydroxychloroquine concentration as an objective marker of poor adherence to treatment of systemic lupus erythematosusAnnals of the Rheumatic Diseases, 66
G. Ruiz‐Irastorza, M. Ramos-Casals, P. Brito‐Zerón, M. Khamashta (2008)
Clinical efficacy and side effects of antimalarials in systemic lupus erythematosus: a systematic reviewAnnals of the Rheumatic Diseases, 69
Shuai Xu, M. Kwa, A. Agarwal, A. Rademaker, R. Kundu (2016)
Sunscreen Product Performance and Other Determinants of Consumer Preferences.JAMA dermatology, 152 8
A. Jorge, C. Ung, L. Young, R. Melles, Hyon Choi (2018)
Hydroxychloroquine retinopathy — implications of research advances for rheumatology careNature Reviews Rheumatology, 14
Tzung Ty, Liu Ys, Chang Hw (2007)
Tacrolimus vs. clobetasol propionate in the treatment of facial cutaneous lupus erythematosus: a randomized, double-blind, bilateral comparison study.British Journal of Dermatology, 156
L. Gombau, Francisco García, Agustín Lahoz, M. Fabre, Pedro Roda-Navarro, P. Majano, J. Alonso-Lebrero, J. Pivel, J. Castell, M. Gómez-Lechón, Salvador González (2006)
Polypodium leucotomos extract: antioxidant activity and disposition.Toxicology in vitro : an international journal published in association with BIBRA, 20 4
M. Ogunsanya, S. Nduaguba, C. Brown (2018)
Incremental health care services and expenditures associated with depression among individuals with cutaneous lupus erythematosus (CLE)Lupus, 27
Felipe García, Pivel Jp, A. Guerrero, A. Brieva, M. Martinez‐Alcazar, M. Caamano-Somoza, Salvador González (2006)
Phenolic components and antioxidant activity of Fernblock, an aqueous extract of the aerial parts of the fern Polypodium leucotomos.Methods and findings in experimental and clinical pharmacology, 28 3
N. Costedoat-Chalumeau, J. Pouchot, G. Guettrot-Imbert, V. Guern, G. Leroux, D. Marra, N. Morel, J. Piette (2013)
Adherence to treatment in systemic lupus erythematosus patients.Best practice & research. Clinical rheumatology, 27 3
Evan Piette, Kristen Foering, A. Chang, J. Okawa, T. Have, R. Feng, V. Werth (2012)
Impact of smoking in cutaneous lupus erythematosus.Archives of dermatology, 148 3
A. Breithaupt, S. Jacob (2012)
Subacute cutaneous lupus erythematosus: a case report of Polypodium leucotomos as an adjuvant therapy.Cutis, 89 4
J. James, XR Kim-Howard, BF Bruner, M. Jonsson, MT McClain, M. Arbuckle, C. Walker, G. Dennis, J. Merrill, J. Harley (2007)
Hydroxychloroquine sulfate treatment is associated with later onset of systemic lupus erythematosusLupus, 16
D. Browning (2013)
Impact of the revised american academy of ophthalmology guidelines regarding hydroxychloroquine screening on actual practice.American journal of ophthalmology, 155 3
A. Kuhn, M. Bijl (2008)
Pathogenesis of cutaneous lupus erythematosusLupus, 17
Turchetti G, Yazdany J, Palla I, Yelin E, Mosca M (2012)
Systemic lupus erythematosus and the economic perspective: a systematic literature review and points to considerClin Exp Rheumatol, 30
C. Francès, A. Cosnes, P. Duhaut, N. Zahr, B. Soutou, S. Ingen-Housz-Oro, D. Bessis, J. Chevrant‐Breton, N. Cordel, D. Lipsker, N. Costedoat-Chalumeau (2012)
Low blood concentration of hydroxychloroquine in patients with refractory cutaneous lupus erythematosus: a French multicenter prospective study.Archives of dermatology, 148 4
American Academy of Dermatology
Sunscreen FAQs, www
M. Marmor, U. Kellner, T. Lai, R. Melles, W. Mieler (2016)
Recommendations on Screening for Chloroquine and Hydroxychloroquine Retinopathy (2016 Revision).Ophthalmology, 123 6
J. Callen, D. Roth, C. Mcgrath, S. Dromgoole (1991)
Safety and efficacy of a broad-spectrum sunscreen in patients with discoid or subacute cutaneous lupus erythematosus.Cutis, 47 2
A. Kuhn, K. Gensch, M. Haust, S. Schneider, G. Bonsmann, N. Gaebelein-Wissing, P. Lehmann, Annette Wons, P. Reitmeir, V. Ruland, T. Luger, T. Ruzicka (2011)
Efficacy of tacrolimus 0.1% ointment in cutaneous lupus erythematosus: a multicenter, randomized, double-blind, vehicle-controlled trial.Journal of the American Academy of Dermatology, 65 1
E. Gutmark, D. Lin, I. Bernstein, S. Wang, B. Chong (2015)
Sunscreen use in patients with cutaneous lupus erythematosusBritish Journal of Dermatology, 173
C. Cusack, C. Danby, J. Fallon, W. Ho, Barbara Murray, J. Brady, P. O’Kelly, N. Ambrose, G. Kearns, G. Murphy (2008)
Photoprotective behaviour and sunscreen use: impact on vitamin D levels in cutaneous lupus erythematosusPhotodermatology, 24
N. Yokogawa, H. Eto, A. Tanikawa, T. Ikeda, K. Yamamoto, T. Takahashi, H. Mizukami, T. Sato, N. Yokota, F. Furukawa (2017)
Effects of Hydroxychloroquine in Patients With Cutaneous Lupus Erythematosus: A Multicenter, Double‐Blind, Randomized, Parallel‐Group TrialArthritis & Rheumatology, 69
S. Manzi, J. Sánchez-Guerrero, J. Merrill, R. Furie, D. Gladman, S. Navarra, E. Ginzler, D. D'cruz, A. Doria, S. Cooper, Z. Zhong, D. Hough, W. Freimuth, M. Petri (2012)
Effects of belimumab, a B lymphocyte stimulator-specific inhibitor, on disease activity across multiple organ domains in patients with systemic lupus erythematosus: combined results from two phase III trialsAnnals of the Rheumatic Diseases, 71
S. Zahn, M. Graef, N. Patsinakidis, A. Landmann, C. Surber, J. Wenzel, A. Kuhn (2014)
Ultraviolet light protection by a sunscreen prevents interferon‐driven skin inflammation in cutaneous lupus erythematosusExperimental Dermatology, 23
N. Teske, Z. Cardon, M. Ogunsanya, X. Li, B. Adams-Huet, B. Chong (2017)
Predictors of low quality of life in patients with discoid lupusBritish Journal of Dermatology, 177
Raymond Lamore SPIII, Patel K, Hilas O (2012)
Belimumab (benlysta): a breakthrough therapy for systemic lupus erythematosusPharm Ther, 37
A. Kuhn, S. Beissert (2005)
Photosensitivity in lupus erythematosusAutoimmunity, 38
Gilliam JN, Sontheimer RD
Distinctive cutaneous subsets in the spectrum of lupus erythematosus
Johal R, Leo MS, Ma B, Sivamani RK (2014)
The economic burden of sunscreen usageDermatol Online J, 20
Joshua Chang, V. Werth (2016)
Therapeutic options for cutaneous lupus erythematosus: recent advances and future prospectsExpert Review of Clinical Immunology, 12
J. Wenzel, A. Landmann, Gero Vorwerk, A. Kuhn (2018)
High expression of B lymphocyte stimulator in lesional keratinocytes of patients with cutaneous lupus erythematosusExperimental Dermatology, 27
Rebecca Vasquez, D. Wang, Q. Tran, B. Adams-Huet, M. Chren, M. Costner, Jack Cohen, Victoria Werth, Benjamin Chong (2013)
A multicentre, cross‐sectional study on quality of life in patients with cutaneous lupus erythematosusBritish Journal of Dermatology, 168
Anshika Kaushik, A. Laumann, Steven Nwe, M. Kwasny, D. West, R. Kundu (2015)
Evaluation of benefit to educational material for photoprotection in those with cutaneous lupus erythematosus.Journal of drugs in dermatology : JDD, 14 4
C. Collins, M. Dall'Era, H. Kan, C. Macahilig, C. Molta, V. Koscielny, D. Chang (2016)
Response to belimumab among patients with systemic lupus erythematosus in clinical practice settings: 24-month results from the OBSErve study in the USALupus Science & Medicine, 3
H. Husein-ElAhmed, J. Callejas-Rubio, R. Ríos-Fernandez, N. Ortego-Centeno (2014)
Refractory subacute cutaneous lupus erythematous responding to a single course of belimumab: a new anti-BLyS human monoclonal antibody.Indian journal of dermatology, venereology and leprology, 80 5
J. Seagrave, E. Barr, T. March, K. Nikula (2004)
EFFECTS OF CIGARETTE SMOKE EXPOSURE AND CESSATION ON INFLAMMATORY CELLS AND MATRIX METALLOPROTEINASE ACTIVITY IN MICEExperimental Lung Research, 30
P. Vashisht, K. Borghoff, J. O'dell, M. Hearth-Holmes (2017)
Belimumab for the treatment of recalcitrant cutaneous lupusLupus, 26
A. Kuhn, E. Aberer, Z. Bata-Csörgő, M. Caproni, A. Dreher, C. Francès, R. Gläser, Hans‐Wilhelm Klötgen, A. Landmann, B. Marinovic, F. Nyberg, R. Olteanu, A. Ranki, J. Szepietowski, B. Volc-Platzer (2017)
S2k guideline for treatment of cutaneous lupus erythematosus – guided by the European Dermatology Forum (EDF) in cooperation with the European Academy of Dermatology and Venereology (EADV)Journal of the European Academy of Dermatology and Venereology, 31
A. Kuhn, K. Gensch, M. Haust, A. Meuth, F. Boyer, P. Dupuy, P. Lehmann, D. Metze, T. Ruzicka (2011)
Photoprotective effects of a broad-spectrum sunscreen in ultraviolet-induced cutaneous lupus erythematosus: a randomized, vehicle-controlled, double-blind study.Journal of the American Academy of Dermatology, 64 1
G. Avgerinou, D. Papafragkaki, A. Nasiopoulou, A. Arapaki, A. Katsambas, P. Stavropoulos (2012)
Effectiveness of topical calcineurin inhibitors as monotherapy or in combination with hydroxychloroquine in cutaneous lupus erythematosusJournal of the European Academy of Dermatology and Venereology, 26
R. Klein, S. Moghadam-Kia, L. Taylor, C. Coley, J. Okawa, Jonathan LoMonico, M. Chren, V. Werth (2011)
Quality of life in cutaneous lupus erythematosus.Journal of the American Academy of Dermatology, 64 5
Abstract Cutaneous lupus erythematosus (CLE)—a common presentation of lupus erythematosus—may exist independently or as a part of the systemic manifestations of systemic lupus erythematosus. The effects of living with and treating a chronic condition such as CLE can be debilitating to a patient's health and finances. The management of patients with CLE is made particularly challenging by poor compliance, limited therapeutic options, scarcity of evidence supporting their use, and significant differences in costs of medications. Effective management of CLE should center on prevention, individualized treatment regimens, and a mutual understanding of the challenges that patients with CLE face. This article seeks to provide an overview of the efficacy, safety, and cost of therapeutic options for CLE.
Lupus: An International Journal – SAGE
Published: May 1, 2019
Keywords: Cutaneous lupus erythematosus; systemic lupus erythematosus; lupus
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