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CA Dreamin’: Carbonic Anhydrase Inhibitors, Macrophages, and Pulmonary Hypertension

CA Dreamin’: Carbonic Anhydrase Inhibitors, Macrophages, and Pulmonary Hypertension EDITORIALS CA Dreamin’: Carbonic Anhydrase Inhibitors, Macrophages, and Pulmonary Hypertension Although it is a rare condition, a diagnosis of pulmonary arterial When added to the drinking water either early or late in the course hypertension (PAH) confers a risk of significant morbidity and of the SuHx model, CAI reduced measures of pulmonary mortality. Characterized by vascular cell hyperproliferation, hypertension. Similar results were observed when metabolic formation of occlusive lesions, and extension of smooth muscle to acidosis was induced by ammonium chloride. The authors also the typically nonmuscular regions of the arterial tree, the vascular showed that expression of proinflammatory mediators (i.e., Tnfa remodeling that occurs during PAH is well described, but it is poorly and Il-6) were upregulated in both the lungs and macrophages of understood from a mechanistic standpoint. Consequently, available SuHx rats and in tissues from patients with PAH. Interestingly, treatments for PAH rely on manipulating pathways involved in macrophages from SuHx animals exhibited both increased vasoconstriction, and no current therapies are aimed primarily at proinflammatory markers and increased markers of alternative slowing or reversing the vascular remodeling. Thus, a major focus in activation. PAH research has been to elucidate pathways involved in the One of the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Respiratory Cell and Molecular Biology Pubmed Central

CA Dreamin’: Carbonic Anhydrase Inhibitors, Macrophages, and Pulmonary Hypertension

American Journal of Respiratory Cell and Molecular Biology , Volume 61 (4) – Oct 1, 2019
2 pages

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Publisher
Pubmed Central
Copyright
Copyright © 2019 by the American Thoracic Society
ISSN
1044-1549
eISSN
1535-4989
DOI
10.1165/rcmb.2019-0122ED
Publisher site
See Article on Publisher Site

Abstract

EDITORIALS CA Dreamin’: Carbonic Anhydrase Inhibitors, Macrophages, and Pulmonary Hypertension Although it is a rare condition, a diagnosis of pulmonary arterial When added to the drinking water either early or late in the course hypertension (PAH) confers a risk of significant morbidity and of the SuHx model, CAI reduced measures of pulmonary mortality. Characterized by vascular cell hyperproliferation, hypertension. Similar results were observed when metabolic formation of occlusive lesions, and extension of smooth muscle to acidosis was induced by ammonium chloride. The authors also the typically nonmuscular regions of the arterial tree, the vascular showed that expression of proinflammatory mediators (i.e., Tnfa remodeling that occurs during PAH is well described, but it is poorly and Il-6) were upregulated in both the lungs and macrophages of understood from a mechanistic standpoint. Consequently, available SuHx rats and in tissues from patients with PAH. Interestingly, treatments for PAH rely on manipulating pathways involved in macrophages from SuHx animals exhibited both increased vasoconstriction, and no current therapies are aimed primarily at proinflammatory markers and increased markers of alternative slowing or reversing the vascular remodeling. Thus, a major focus in activation. PAH research has been to elucidate pathways involved in the One of the

Journal

American Journal of Respiratory Cell and Molecular BiologyPubmed Central

Published: Oct 1, 2019

References