Access the full text.
Sign up today, get DeepDyve free for 14 days.
References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.
EDITORIALS CA Dreamin’: Carbonic Anhydrase Inhibitors, Macrophages, and Pulmonary Hypertension Although it is a rare condition, a diagnosis of pulmonary arterial When added to the drinking water either early or late in the course hypertension (PAH) confers a risk of significant morbidity and of the SuHx model, CAI reduced measures of pulmonary mortality. Characterized by vascular cell hyperproliferation, hypertension. Similar results were observed when metabolic formation of occlusive lesions, and extension of smooth muscle to acidosis was induced by ammonium chloride. The authors also the typically nonmuscular regions of the arterial tree, the vascular showed that expression of proinflammatory mediators (i.e., Tnfa remodeling that occurs during PAH is well described, but it is poorly and Il-6) were upregulated in both the lungs and macrophages of understood from a mechanistic standpoint. Consequently, available SuHx rats and in tissues from patients with PAH. Interestingly, treatments for PAH rely on manipulating pathways involved in macrophages from SuHx animals exhibited both increased vasoconstriction, and no current therapies are aimed primarily at proinflammatory markers and increased markers of alternative slowing or reversing the vascular remodeling. Thus, a major focus in activation. PAH research has been to elucidate pathways involved in the One of the
American Journal of Respiratory Cell and Molecular Biology – Pubmed Central
Published: Oct 1, 2019
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.