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The Nature of a Nematode Growth Factor. Iii Growth and Maturation of Caenorhabditis Briggsae On Protein-Haemin Co-Precipitates

The Nature of a Nematode Growth Factor. Iii Growth and Maturation of Caenorhabditis Briggsae On... THE NATURE OF A NEMATODE GROWTH FACTOR. III GROWTH AND MATURATION OF CAENORHABDITIS BRIGGSAE ON PROTEIN- HAEMIN CO-PRECIPITATES BY J. R. VANFLETEREN Laboratoria voor Morfologie en Systematiek, Museum voor Dierkunde, Rijksuniversiteit Gent, Ledeganckstraat 35, B-9000 Gent (Belgium) The growth promoting activity of protein-haemin co-precipitates from ferritin, apoferritin, transferrin, bovine serum albumin, conalbumin and egg white on maturation and reproduction of C. briggsae has been evaluated. Ferritin, apoferritin and transferrin were found to be biologically highly active in the presence of haemin. Bovine serum albumin, conalbumin and egg white were slightly active. Maturation and reproduction of C. briggsae on the coagulates from bovine serum albumin and egg white were nearly independent of the dose administered, probably because the limited availability of haemin from these coagulates permits but slow growth, even in the presence of abundant proteinaceous material. Bovine serum albumin, egg white and conalbumin failed to support continuous growth of C. briggsae. It is supposed that the limited availability of haemin from these coagulates inhibits normal maturation and reproduction of the F1 progeny. These experiments clearly demonstrate the requirement for particulate haem. The requirement for specific protein is not supported. Proteins, especially globulins, show a marked tendency to adsorb http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nematologica Brill

The Nature of a Nematode Growth Factor. Iii Growth and Maturation of Caenorhabditis Briggsae On Protein-Haemin Co-Precipitates

Vanfleteren, J.R.
Nematologica , Volume 22 (1): 10 – Jan 1, 1976
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Publisher
Brill
Copyright
Copyright © Koninklijke Brill NV, Leiden, The Netherlands
ISSN
0028-2596
eISSN
1875-2926
DOI
10.1163/187529276X00111
Publisher site
See Article on Publisher Site

Abstract

THE NATURE OF A NEMATODE GROWTH FACTOR. III GROWTH AND MATURATION OF CAENORHABDITIS BRIGGSAE ON PROTEIN- HAEMIN CO-PRECIPITATES BY J. R. VANFLETEREN Laboratoria voor Morfologie en Systematiek, Museum voor Dierkunde, Rijksuniversiteit Gent, Ledeganckstraat 35, B-9000 Gent (Belgium) The growth promoting activity of protein-haemin co-precipitates from ferritin, apoferritin, transferrin, bovine serum albumin, conalbumin and egg white on maturation and reproduction of C. briggsae has been evaluated. Ferritin, apoferritin and transferrin were found to be biologically highly active in the presence of haemin. Bovine serum albumin, conalbumin and egg white were slightly active. Maturation and reproduction of C. briggsae on the coagulates from bovine serum albumin and egg white were nearly independent of the dose administered, probably because the limited availability of haemin from these coagulates permits but slow growth, even in the presence of abundant proteinaceous material. Bovine serum albumin, egg white and conalbumin failed to support continuous growth of C. briggsae. It is supposed that the limited availability of haemin from these coagulates inhibits normal maturation and reproduction of the F1 progeny. These experiments clearly demonstrate the requirement for particulate haem. The requirement for specific protein is not supported. Proteins, especially globulins, show a marked tendency to adsorb

Journal

Nematologica – Brill

Published: Jan 1, 1976

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