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Telomere length analysis on cord blood cells by the flow-FISH method

Telomere length analysis on cord blood cells by the flow-FISH method Haematologia , Vol. 32, No. 3, pp. 265– 269 (2002) Ó VSP 2002. Also available online - www.vsppub.com Short communication Telomere length analysis on cord blood cells by the  ow-FISH method NÓRA REGÉCZY 1 ; 2 , SÁNDOR VALENT 3 , LUCA KORMOS 4 , MELINDA HAJDU 1 , LASZLO GOPCSA 1 and KATALIN PÁLÓCZI 1 ; 5 ; ¤ 1 National Medical Center, Institute of Haematology and Immunology, Budapest, Hungary 2 Research Group of Hungarian Academy of Sciences, Budapest, Hungary 3 Second Department of Obstetrics and Gynecology, Budapest, Hungary 4 School of Ph.D. Studies, Semmelweis University, Budapest, Hungary 5 Department of Immunology, Semmelweis University, Budapest, Hungary Abstract —Telomerase is the enzyme responsible for synthesizing telomeric repeats at the ends of chromosomes to maintain telomere length. Recent studies have suggested that telomere shortening may serve as a surrogate marker of the progression of malignant disorders and seems to be accelerated in allogeneic bone marrow transplant recipients. In this study, the results of the telomere length of nine cord blood mononuclear cell samples are presented. Telomere length was measured by the  ow-FISH method, using a peptide nucleic acid probe. The proportion of cord blood cell subsets (CD19/CD34/CD3) http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Haematologia Brill

Telomere length analysis on cord blood cells by the flow-FISH method

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Publisher
Brill
Copyright
© 2002 Koninklijke Brill NV, Leiden, The Netherlands
ISSN
0017-6559
eISSN
1568-5594
DOI
10.1163/15685590260461075
Publisher site
See Article on Publisher Site

Abstract

Haematologia , Vol. 32, No. 3, pp. 265– 269 (2002) Ó VSP 2002. Also available online - www.vsppub.com Short communication Telomere length analysis on cord blood cells by the  ow-FISH method NÓRA REGÉCZY 1 ; 2 , SÁNDOR VALENT 3 , LUCA KORMOS 4 , MELINDA HAJDU 1 , LASZLO GOPCSA 1 and KATALIN PÁLÓCZI 1 ; 5 ; ¤ 1 National Medical Center, Institute of Haematology and Immunology, Budapest, Hungary 2 Research Group of Hungarian Academy of Sciences, Budapest, Hungary 3 Second Department of Obstetrics and Gynecology, Budapest, Hungary 4 School of Ph.D. Studies, Semmelweis University, Budapest, Hungary 5 Department of Immunology, Semmelweis University, Budapest, Hungary Abstract —Telomerase is the enzyme responsible for synthesizing telomeric repeats at the ends of chromosomes to maintain telomere length. Recent studies have suggested that telomere shortening may serve as a surrogate marker of the progression of malignant disorders and seems to be accelerated in allogeneic bone marrow transplant recipients. In this study, the results of the telomere length of nine cord blood mononuclear cell samples are presented. Telomere length was measured by the  ow-FISH method, using a peptide nucleic acid probe. The proportion of cord blood cell subsets (CD19/CD34/CD3)

Journal

HaematologiaBrill

Published: Jan 1, 2002

Keywords: telomere length; flow-FISH.; Cord blood

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