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Haematologia , Vol. 32, No. 3, pp. 265– 269 (2002) Ó VSP 2002. Also available online - www.vsppub.com Short communication Telomere length analysis on cord blood cells by the ow-FISH method NÓRA REGÉCZY 1 ; 2 , SÁNDOR VALENT 3 , LUCA KORMOS 4 , MELINDA HAJDU 1 , LASZLO GOPCSA 1 and KATALIN PÁLÓCZI 1 ; 5 ; ¤ 1 National Medical Center, Institute of Haematology and Immunology, Budapest, Hungary 2 Research Group of Hungarian Academy of Sciences, Budapest, Hungary 3 Second Department of Obstetrics and Gynecology, Budapest, Hungary 4 School of Ph.D. Studies, Semmelweis University, Budapest, Hungary 5 Department of Immunology, Semmelweis University, Budapest, Hungary Abstract —Telomerase is the enzyme responsible for synthesizing telomeric repeats at the ends of chromosomes to maintain telomere length. Recent studies have suggested that telomere shortening may serve as a surrogate marker of the progression of malignant disorders and seems to be accelerated in allogeneic bone marrow transplant recipients. In this study, the results of the telomere length of nine cord blood mononuclear cell samples are presented. Telomere length was measured by the ow-FISH method, using a peptide nucleic acid probe. The proportion of cord blood cell subsets (CD19/CD34/CD3)
Haematologia – Brill
Published: Jan 1, 2002
Keywords: telomere length; flow-FISH.; Cord blood
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