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α-thalassaemia (Hb-Bart's) in Rajasthan (India)

α-thalassaemia (Hb-Bart's) in Rajasthan (India) Haematologia , Vol. 30, No. 3, pp. 209 – 213 (2000) Ó VSP 2000. Short communication α -thalassaemia (Hb-Bart’s) in Rajasthan (India) S. L. CHOUBISA, D. K. CHOUBISA and S. KHARE P.G. Department of Zoology, S.B.P. Government College, M.L. Sukhadia University, Dungarpur-314 001, India Abstract —A total of 1647 cord blood samples (618 of scheduled tribes, 487 of scheduled castes and 542 of general castes) of newborns from the Banswara, Bhilwara, Chittorgarh, Dungarpur, Sirohi and Udaipur districts of the Aravali hilly region of Rajasthan were investigated electrophoretically for evidence of Hb-Bart’s ( α -thalassaemia). Hb-Bart’s was encountered in 31 (1.88%) neonates constituting 1.8 to 12.6% of their total haemoglobin. Of these, 24 (1.46%) were of α -thalassaemia 1 and 7 (0.42%) of α -thalassaemia 2. The incidence of α -thalassaemia genes varied from 3.07% in the scheduled tribes, 1.43% in the scheduled castes to 0.77% in the general castes populations giving an overall incidence of 1.88%. Except Hb-Bart’s allele, no other mutant haemoglobins were observed. Key words : Cord blood; Hb-Bart’s; α -thalassaemia; Rajasthan. INTRODUCTION It is well known that in α -thalassaemia there is defective synthesis of the α -chains of haemoglobin (Hb) and consequently production of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Haematologia Brill

α-thalassaemia (Hb-Bart's) in Rajasthan (India)

Choubisa, S. L.; Khare, S.; Choubisa, D. K.
Haematologia , Volume 30 (3): 209 – Jan 1, 2000
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Publisher
Brill
Copyright
© 2000 Koninklijke Brill NV, Leiden, The Netherlands
ISSN
0017-6559
eISSN
1568-5594
DOI
10.1163/156855900300109215
Publisher site
See Article on Publisher Site

Abstract

Haematologia , Vol. 30, No. 3, pp. 209 – 213 (2000) Ó VSP 2000. Short communication α -thalassaemia (Hb-Bart’s) in Rajasthan (India) S. L. CHOUBISA, D. K. CHOUBISA and S. KHARE P.G. Department of Zoology, S.B.P. Government College, M.L. Sukhadia University, Dungarpur-314 001, India Abstract —A total of 1647 cord blood samples (618 of scheduled tribes, 487 of scheduled castes and 542 of general castes) of newborns from the Banswara, Bhilwara, Chittorgarh, Dungarpur, Sirohi and Udaipur districts of the Aravali hilly region of Rajasthan were investigated electrophoretically for evidence of Hb-Bart’s ( α -thalassaemia). Hb-Bart’s was encountered in 31 (1.88%) neonates constituting 1.8 to 12.6% of their total haemoglobin. Of these, 24 (1.46%) were of α -thalassaemia 1 and 7 (0.42%) of α -thalassaemia 2. The incidence of α -thalassaemia genes varied from 3.07% in the scheduled tribes, 1.43% in the scheduled castes to 0.77% in the general castes populations giving an overall incidence of 1.88%. Except Hb-Bart’s allele, no other mutant haemoglobins were observed. Key words : Cord blood; Hb-Bart’s; α -thalassaemia; Rajasthan. INTRODUCTION It is well known that in α -thalassaemia there is defective synthesis of the α -chains of haemoglobin (Hb) and consequently production of

Journal

Haematologia – Brill

Published: Jan 1, 2000

Keywords: Cord blood; Rajasthan; Hb-Bart's; alpha-thalassaemia

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