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MORPHOLOGICAL, MOLECULAR AND FUNCTIONAL CHARACTERISTICS OF TWO SUBPOPULATIONS OF SOMATOTROPES IN THE AGED MALE RAT by PABLO M. DOBADO-BERRIOS, ANTONIO RUIZ-NAVARRO, MARIA M. MALAGON, CORINNE DIEULOIS, JOSE C. GARRIDO and FRANCISCO GRACIA-NAVARRO (Department of Cell Biology, University of Córdoba, Spain) ABSTRACT Cellular heterogeneity has been described for several pituitary cell types. In the present study we have demonstrated that, in the pituitary of the ageing male rat, two subpopula- tions of growth hormone (GH)-producing cells occur that differ in morphological, molecular and functional aspects. These results may provide a cellular basis to the understanding of changes in GH through ageing. KEY WORDS: cell heterogeneity, growth hormone, agcing. Many investigators have suggested that populations of classic pituitary cell types may consist of subtypes showing different morphology and/ or functionality (TAKAHASHI, 1992). The aim of this study was to investigate the existence of subpopulations of somatotrope cells in the pituitary gland of the male rat, and to determine their morphological, molecular and functional characteristics. Since the age-related decline in GH secretion seems to be a basic mechanism in mammalian ageing (SONNTAG & MEITES, 1988) we have examined a possible involvement of somatotrope cell heterogeneity in GH secretion studying animals of
Netherlands Journal of Zoology (in 2003 continued as Animal Biology) – Brill
Published: Jan 1, 1994
Keywords: agcing; growth hormone; cell heterogeneity
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