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Human induced pluripotent stem cell–derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicityNature Medicine, 22
Mirja Schulze, M. Lemoine, Alexander Fischer, K. Scherschel, R. David, K. Riecken, A. Hansen, T. Eschenhagen, Bärbel Ulmer (2019)
Dissecting hiPSC-CM pacemaker function in a cardiac organoid model.Biomaterials, 206
Jia Liu, L. Volkers, W. Jangsangthong, C. Bart, M. Engels, Guangqian Zhou, M. Schalij, D. Ypey, D. Pijnappels, A. Vries (2018)
Generation and primary characterization of iAM-1, a versatile new line of conditionally immortalized atrial myocytes with preserved cardiomyogenic differentiation capacityCardiovascular Research, 114
S. Lundy, Wei-zhong Zhu, Michael Regnier, M. Laflamme (2013)
Structural and functional maturation of cardiomyocytes derived from human pluripotent stem cells.Stem cells and development, 22 14
T. Monticello, Thomas Jones, D. Dambach, D. Potter, M. Bolt, Maggie Liu, D. Keller, T. Hart, V. Kadambi (2017)
Current nonclinical testing paradigm enables safe entry to First‐In‐Human clinical trials: The IQ consortium nonclinical to clinical translational databaseToxicology and Applied Pharmacology, 334
(2018)
A human cardiomyocyte-based platform for the profiling of positive inotropes with potential to treat heart failure [abstract P3492
Nathalie Nguyen, William Nguyen, Brynna Nguyenton, P. Ratchada, G. Page, Paul Miller, A. Ghetti, N. Abi-Gerges (2017)
Adult Human Primary Cardiomyocyte-Based Model for the Simultaneous Prediction of Drug-Induced Inotropic and Pro-arrhythmia RiskFrontiers in Physiology, 8
T. Colatsky, B. Fermini, G. Gintant, Jennifer Pierson, P. Sager, Y. Sekino, D. Strauss, N. Stockbridge (2016)
The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative - Update on progress.Journal of pharmacological and toxicological methods, 81
Haoyu Zeng, Bharath Balasubramanian, A. Lagrutta, F. Sannajust (2018)
Response of human induced pluripotent stem cell-derived cardiomyocytes to several pharmacological agents when intrinsic syncytial pacing is overcome by acute external stimulation.Journal of pharmacological and toxicological methods, 91
N. Isoherranen, R. Madabushi, Shiew-Mei Huang (2019)
Emerging Role of Organ‐on‐a‐Chip Technologies in Quantitative Clinical Pharmacology EvaluationClinical and Translational Science, 12
Haodi Wu, Huaxiao Yang, J. Rhee, Joe Zhang, C. Lam, Karim Sallam, Alex Chang, Ning Ma, Jaecheol Lee, Hao Zhang, H. Blau, D. Bers, Joseph Wu (2019)
Modelling diastolic dysfunction in induced pluripotent stem cell-derived cardiomyocytes from hypertrophic cardiomyopathy patients.European heart journal
T. Magdy, A. Schuldt, Joseph Wu, D. Bernstein, P. Burridge (2018)
Human Induced Pluripotent Stem Cell (hiPSC)-Derived Cells to Assess Drug Cardiotoxicity: Opportunities and Problems.Annual review of pharmacology and toxicology, 58
Arun Sharma, P. Burridge, Wesley McKeithan, Ricardo Serrano, Praveen Shukla, N. Sayed, Jared Churko, T. Kitani, Haodi Wu, Alexandra Holmström, Elena Matsa, Y. Zhang, Anusha Kumar, A. Fan, J. Álamo, Sean Wu, J. Moslehi, M. Mercola, Joseph Wu (2017)
High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cellsScience Translational Medicine, 9
Jagoree Roy, C. Wigington, N. Damle, I. Ulengin-Talkish, S. Cho, Norman Davey, Y. Ivarsson, Cassandra Wong, A. Gingras, M. Cyert (2017)
2017 ASCB Annual Meeting AbstractsMolecular Biology of the Cell, 28
Yimu Zhao, Naimeh Rafatian, E. Wang, N. Feric, B. Lai, Ericka Knee-Walden, P. Backx, M. Radisic (2020)
Engineering microenvironment for human cardiac tissue assembly in heart-on-a-chip platform.Matrix biology : journal of the International Society for Matrix Biology
D. Lieu, Ji-Dong Fu, N. Chiamvimonvat, K. Tung, G. McNerney, T. Huser, G. Keller, C. Kong, Ronald Li (2013)
Mechanism-Based Facilitated Maturation of Human Pluripotent Stem Cell–Derived CardiomyocytesCirculation: Arrhythmia and Electrophysiology, 6
M. Waring, J. Arrowsmith, A. Leach, P. Leeson, Sam Mandrell, R. Owen, G. Pairaudeau, W. Pennie, S. Pickett, Jibo Wang, Owen Wallace, A. Weir (2015)
An analysis of the attrition of drug candidates from four major pharmaceutical companiesNature Reviews Drug Discovery, 14
T. Kitani, S. Ong, C. Lam, J. Rhee, Joe Zhang, Angelos Oikonomopoulos, Ning Ma, Lei Tian, Jaecheol Lee, M. Telli, R. Witteles, Arun Sharma, N. Sayed, Joseph Wu (2019)
Human-Induced Pluripotent Stem Cell Model of Trastuzumab-Induced Cardiac Dysfunction in Patients With Breast Cancer.Circulation
N. Iost, László Virág, M. Opincariu, Janos Szecsi, András Varró, J. Papp (1998)
Delayed rectifier potassium current in undiseased human ventricular myocytes.Cardiovascular research, 40 3
Phrma 2016 biopharmaceutical research industry profile
T. Feaster, A. Cadar, Lili Wang, C. Williams, Y. Chun, Jonathan Hempel, Nathaniel Bloodworth, W. Merryman, C. Lim, Joseph Wu, B. Knollmann, C. Hong (2015)
Matrigel Mattress: A Method for the Generation of Single Contracting Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes.Circulation Research
Yimu Zhao, Naimeh Rafatian, N. Feric, B. Cox, Roozbeh Aschar-Sobbi, E. Wang, P. Aggarwal, Boyang Zhang, Genevieve Conant, Kacey Ronaldson-Bouchard, A. Pahnke, S. Protze, Jeehoon Lee, Locke Huyer, Danica Jekic, Anastasia Wickeler, H. Naguib, G. Keller, G. Vunjak‐Novakovic, U. Broeckel, P. Backx, M. Radisic (2019)
A Platform for Generation of Chamber-Specific Cardiac Tissues and Disease ModelingCell, 176
M. Sanna, Jiayu Liao, E. Jo, C. Alfonso, M. Ahn, M. Peterson, B. Webb, S. Lefebvre, J. Chun, N. Gray, H. Rosen (2004)
Sphingosine 1-Phosphate (S1P) Receptor Subtypes S1P1 and S1P3, Respectively, Regulate Lymphocyte Recirculation and Heart Rate*Journal of Biological Chemistry, 279
L. Ewart, Mike Aylott, M. Deurinck, M. Engwall, D. Gallacher, H. Geys, P. Jarvis, H. Ju, D. Leishman, Louise Leong, N. McMahon, A. Mead, P. Milliken, W. Suter, A. Teisman, K. Ammel, H. Vargas, R. Wallis, J. Valentin (2014)
The concordance between nonclinical and phase I clinical cardiovascular assessment from a cross-company data sharing initiative.Toxicological sciences : an official journal of the Society of Toxicology, 142 2
C. Denning, V. Borgdorff, James Crutchley, K. Firth, Vinoj George, S. Kalra, A. Kondrashov, Minh Hoang, Diogo Mosqueira, A. Patel, L. Prodanov, D. Rajamohan, W. Skarnes, James Smith, L. Young (2016)
Cardiomyocytes from human pluripotent stem cells: From laboratory curiosity to industrial biomedical platform☆Biochimica et Biophysica Acta, 1863
Alexander Blanchette, Fabian Grimm, Chimedullam Dalaijamts, Nan-Hung Hsieh, Kyle Ferguson, Yu-Syuan Luo, I. Rusyn, W. Chiu (2018)
Thorough QT/QTc in a Dish: An In Vitro Human Model That Accurately Predicts Clinical Concentration‐QTc RelationshipsClinical Pharmacology & Therapeutics, 105
Daniel Millard, Q. Dang, Hong Shi, Xiaou Zhang, C. Strock, U. Kraushaar, Haoyu Zeng, P. Levesque, Hua-rong Lu, J. Guillon, Joseph Wu, Yingxin Li, G. Luerman, B. Anson, Liang Guo, Mike Clements, Y. Abassi, James Ross, Jennifer Pierson, G. Gintant (2018)
Cross-Site Reliability of Human Induced Pluripotent stem cell-derived Cardiomyocyte Based Safety Assays Using Microelectrode Arrays: Results from a Blinded CiPA Pilot StudyToxicological Sciences, 164
C. Rao, T. Prodromakis, L. Kolker, U. Chaudhry, T. Trantidou, A. Sridhar, Claire Weekes, P. Camelliti, S. Harding, A. Darzi, M. Yacoub, T. Athanasiou, C. Terracciano (2013)
The effect of microgrooved culture substrates on calcium cycling of cardiac myocytes derived from human induced pluripotent stem cellsBiomaterials, 34
Guang-ran Guo, Liang Chen, Man Rao, Kai Chen, Jiang-ping Song, Sheng-Shou Hu (2018)
A modified method for isolation of human cardiomyocytes to model cardiac diseasesJournal of Translational Medicine, 16
Wendy Keung, K. Boheler, Ronald Li (2014)
Developmental cues for the maturation of metabolic, electrophysiological and calcium handling properties of human pluripotent stem cell-derived cardiomyocytesStem Cell Research & Therapy, 5
J. Cohen, Joshua Babiarz, Rory Abrams, Liang Guo, Seiji Kameoka, E. Chiao, J. Taunton, K. Kolaja (2011)
Use of human stem cell derived cardiomyocytes to examine sunitinib mediated cardiotoxicity and electrophysiological alterations.Toxicology and applied pharmacology, 257 1
J. Handler (2017)
Book Review: A Comprehensive Guide to Toxicology in Nonclinical Drug DevelopmentInternational Journal of Toxicology, 36
P. Gergely, B. Nuesslein‐Hildesheim, D. Guerini, V. Brinkmann, M. Traebert, C. Bruns, Shifeng Pan, N. Gray, K. Hinterding, N. Cooke, A. Groenewegen, A. Vitaliti, Tobias Sing, O. Luttringer, J. Yang, A. Gardin, N. Wang, W. Crumb, M. Saltzman, Mara Rosenberg, E. Wallström (2012)
The selective sphingosine 1-phosphate receptor modulator BAF312 redirects lymphocyte distribution and has species-specific effects on heart rateBritish Journal of Pharmacology, 167
L. Vernetti, A. Gough, N. Baetz, S. Blutt, J. Broughman, Jacquelyn Brown, Jennifer Foulke-Abel, Nesrin Hasan, Julie In, E. Kelly, O. Kovbasnjuk, Jonathan Repper, N. Senutovitch, Janet Stabb, C. Yeung, Nick Zachos, M. Donowitz, M. Estes, J. Himmelfarb, G. Truskey, J. Wikswo, D. Taylor (2017)
Corrigendum: Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal MuscleScientific Reports, 7
L. Mulieri, G. Hasenfuss, B. Leavitt, P. Allen, N. Alpert (1992)
Altered Myocardial Force‐Frequency Relation in Human Heart FailureCirculation, 85
Lisa Marroquin, J. Hynes, J. Dykens, J. Jamieson, Y. Will (2007)
Circumventing the Crabtree effect: replacing media glucose with galactose increases susceptibility of HepG2 cells to mitochondrial toxicants.Toxicological sciences : an official journal of the Society of Toxicology, 97 2
Amy Cochrane, Hugo Albers, R. Passier, C. Mummery, A. Berg, V. Orlova, A. Meer (2019)
Advanced in vitro models of vascular biology: Human induced pluripotent stem cells and organ-on-chip technology.Advanced drug delivery reviews
J. Moberly, D. Ford, H. Zahir, Shuquan Chen, T. Vollmer (2012)
Pharmacological effects of CS-0777, a selective sphingosine 1-phosphate receptor-1 modulator: Results from a 12-week, open-label pilot study in multiple sclerosis patientsJournal of Neuroimmunology, 246
EMA recommends avoidance of certain hepatitis C medicines and amiodarone together
D. Beuckelmann, M. Näbauer, E. Erdmann (1992)
Intracellular Calcium Handling in Isolated Ventricular Myocytes From Patients With Terminal Heart FailureCirculation, 85
Ksenia Blinova, Q. Dang, Daniel Millard, Godfrey Smith, Jennifer Pierson, Liang Guo, Mathew Brock, Hua-rong Lu, U. Kraushaar, Haoyu Zeng, Hong Shi, Xiaoyu Zhang, K. Sawada, Tomoharu Osada, Y. Kanda, Y. Sekino, Li Pang, T. Feaster, R. Kettenhofen, N. Stockbridge, D. Strauss, G. Gintant (2018)
International Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential AssessmentCell reports, 24
S. Renet, M. Chaumais, T. Antonini, Alexandre Zhao, L. Thomas, A. Savouré, D. Samuel, J. Duclos‐Vallée, V. Algalarrondo (2015)
Extreme bradycardia after first doses of sofosbuvir and daclatasvir in patients receiving amiodarone: 2 cases including a rechallenge.Gastroenterology, 149 6
L. Sala, B. Meer, L. Tertoolen, J. Bakkers, M. Bellin, Richard Davis, C. Denning, Michel Dieben, T. Eschenhagen, Elisa Giacomelli, C. Grandela, A. Hansen, E. Holman, M. Jongbloed, S. Kamel, C. Koopman, Quentin Lachaud, I. Mannhardt, M. Mol, Diogo Mosqueira, V. Orlova, R. Passier, Marcelo Ribeiro, Umber Saleem, Godfrey Smith, F. Burton, C. Mummery (2017)
MUSCLEMOTIONCirculation Research, 122
(2019)
Cardiomyocytes from SP EC IA L A RT IC LE Pang et al FDA Workshop: Improving Cardiotoxicity
T. Dhar, Hai-yun Xiao, Jenny Xie, L. Lehman-Mckeeman, Dauh-Rurng Wu, M. Dabros, Xiaoxia Yang, T. Taylor, Xia Zhou, Elizabeth Heimrich, Rochelle Thomas, K. McIntyre, B. Warrack, Hong Shi, P. Levesque, Jiajie Zhu, J. Hennan, P. Balimane, Zheng Yang, A. Marino, G. Cornelius, C. D’arienzo, A. Mathur, D. Shen, M. Cvijic, L. Salter-Cid, J. Barrish, P. Carter, A. Dyckman (2016)
Identification and Preclinical Pharmacology of BMS-986104: A Differentiated S1P1 Receptor Modulator in Clinical Trials.ACS medicinal chemistry letters, 7 3
G. Page, P. Ratchada, Y. Miron, Guido Steiner, A. Ghetti, Paul Miller, Jack Reynolds, Ken Wang, A. Greiter‐Wilke, L. Polonchuk, M. Traebert, G. Gintant, N. Abi-Gerges (2016)
Human ex-vivo action potential model for pro-arrhythmia risk assessment.Journal of pharmacological and toxicological methods, 81
D. Marcoux, Hai-yun Xiao, T. Dhar, Jenny Xie, L. Lehman-Mckeeman, Dauh-Rurng Wu, M. Dabros, Xiaoxia Yang, T. Taylor, Xia Zhou, Elizabeth Heimrich, Rochelle Thomas, K. McIntyre, Hong Shi, P. Levesque, Huadong Sun, Zheng Yang, A. Marino, G. Cornelius, C. D’arienzo, Anuradha Gupta, Bala Pragalathan, R. Rampulla, A. Mathur, D. Shen, M. Cvijic, L. Salter-Cid, L. Lombardo, P. Carter, A. Dyckman (2017)
Identification of potent tricyclic prodrug S1P1 receptor modulators.MedChemComm, 8 4
Ravi Vaidyanathan, Yogananda Markandeya, T. Kamp, J. Makielski, C. January, L. Eckhardt (2016)
IK1-enhanced human-induced pluripotent stem cell-derived cardiomyocytes: an improved cardiomyocyte model to investigate inherited arrhythmia syndromes.American journal of physiology. Heart and circulatory physiology, 310 11
Yusheng Qu, G. Page, N. Abi-Gerges, Paul Miller, A. Ghetti, H. Vargas (2018)
Action Potential Recording and Pro-arrhythmia Risk Analysis in Human Ventricular TrabeculaeFrontiers in Physiology, 8
High-throughput analysis of contractile function in adult canine cardiomyocytes via kinetic image cytometry
Bryan Koci, G. Luerman, A. Duenbostell, R. Kettenhofen, H. Bohlen, L. Coyle, Brian Knight, W. Ku, W. Volberg, J. Woska, M. Brown (2017)
An impedance‐based approach using human iPSC‐derived cardiomyocytes significantly improves in vitro prediction of in vivo cardiotox liabilitiesToxicology and Applied Pharmacology, 329
Hiroyuki Ando, T. Yoshinaga, Wataru Yamamoto, K. Asakura, Takaaki Uda, Tomohiko Taniguchi, Atsuko Ojima, Raku Shinkyo, K. Kikuchi, Tomoharu Osada, S. Hayashi, Chieko Kasai, N. Miyamoto, Hiroyuki Tashibu, D. Yamazaki, A. Sugiyama, Y. Kanda, K. Sawada, Y. Sekino (2017)
A new paradigm for drug-induced torsadogenic risk assessment using human iPS cell-derived cardiomyocytes.Journal of pharmacological and toxicological methods, 84
R. Coppini, C. Ferrantini, Alessandro Aiazzi, L. Mazzoni, L. Sartiani, A. Mugelli, C. Poggesi, E. Cerbai (2014)
Isolation and functional characterization of human ventricular cardiomyocytes from fresh surgical samples.Journal of visualized experiments : JoVE, 86
C. Terrenoire, Kai Wang, Kelvin Tung, W. Chung, R. Pass, Jonathan Lu, J. Jean, Amel Omari, K. Sampson, D. Kotton, G. Keller, R. Kass (2013)
Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex geneticsThe Journal of General Physiology, 141
Priyanka Garg, Angelos Oikonomopoulos, Haodong Chen, Yingxin Li, C. Lam, Karim Sallam, M. Perez, R. Lux, M. Sanguinetti, Joseph Wu (2018)
Genome Editing of Induced Pluripotent Stem Cells to Decipher Cardiac Channelopathy Variant.Journal of the American College of Cardiology, 72 1
A. Faqi (2016)
A Comprehensive Guide to Toxicology in Nonclinical Drug Development Ed. 2
A. Lagrutta, Haoyu Zeng, J. Imredy, Bharath Balasubramanian, Spencer Dech, E. Lis, Jixin Wang, Jin Zhai, J. DeGeorge, F. Sannajust (2016)
Interaction between amiodarone and hepatitis-C virus nucleotide inhibitors in human induced pluripotent stem cell-derived cardiomyocytes and HEK-293 Cav1.2 over-expressing cells.Toxicology and applied pharmacology, 308
Roy Vaz, T. Klabunde (2008)
Antitargets : prediction and prevention of drug side effects
A. Hansen, A. Eder, M. Bönstrup, M. Flato, M. Mewe, Sebastian Schaaf, B. Aksehirlioglu, A. Schwoerer, June Uebeler, T. Eschenhagen (2010)
Development of a Drug Screening Platform Based on Engineered Heart TissueCirculation Research, 107
F. Stillitano, J. Hansen, C. Kong, I. Karakikes, C. Funck-Brentano, L. Geng, S. Scott, S. Reynier, Ma Wu, Yannick Valogne, C. Desseaux, J. Salem, D. Jeziorowska, N. Zahr, Ronald Li, R. Iyengar, R. Hajjar, J. Hulot (2017)
Modeling susceptibility to drug-induced long QT with a panel of subject-specific induced pluripotent stem cellseLife, 6
Sarah Lamore, Ernst Ahlberg, S. Boyer, M. Lamb, M. Hortigon-Vinagre, V. Rodriguez, Godfrey Smith, J. Sagemark, L. Carlsson, Stephanie Bates, A. Choy, Jonna Stålring, Clay Scott, M. Peters (2017)
Deconvoluting Kinase Inhibitor Induced CardiotoxicityToxicological Sciences, 158
Revised recommendations for cardiovascular monitoring and use of multiple sclerosis drug Gilenya (fingolimod)
J. Huo, A. Kamalakar, Xi Yang, B. Word, N. Stockbridge, B. Lyn-Cook, Li Pang (2016)
Evaluation of Batch Variations in Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes from 2 Major SuppliersToxicological Sciences, 156
Liang Guo, Rory Abrams, Joshua Babiarz, Jennifer Cohen, Seiji Kameoka, Martin Sanders, E. Chiao, K. Kolaja (2011)
Estimating the risk of drug-induced proarrhythmia using human induced pluripotent stem cell-derived cardiomyocytes.Toxicological sciences : an official journal of the Society of Toxicology, 123 1
Payal Rana, B. Anson, S. Engle, Y. Will (2012)
Characterization of human-induced pluripotent stem cell-derived cardiomyocytes: bioenergetics and utilization in safety screening.Toxicological sciences : an official journal of the Society of Toxicology, 130 1
L. Polonchuk, M. Chabria, L. Badi, J. Hoflack, G. Figtree, M. Davies, C. Gentile (2017)
Cardiac spheroids as promising in vitro models to study the human heart microenvironmentScientific Reports, 7
Renjun Zhu, A. Blazeski, E. Poon, K. Costa, L. Tung, K. Boheler (2014)
Physical developmental cues for the maturation of human pluripotent stem cell-derived cardiomyocytesStem Cell Research & Therapy, 5
J. Bustamante, T. Watanabe, D. Murphy, T. Mcdonald (1982)
Isolation of single atrial and ventricular cells from the human heart.Canadian Medical Association journal, 126 7
Oliver Britton, N. Abi-Gerges, G. Page, A. Ghetti, Paul Miller, B. Rodríguez (2017)
Quantitative Comparison of Effects of Dofetilide, Sotalol, Quinidine, and Verapamil between Human Ex vivo Trabeculae and In silico Ventricular Models Incorporating Inter-Individual Action Potential VariabilityFrontiers in Physiology, 8
F. Ponti (2008)
Pharmacological and Regulatory Aspects of QT Prolongation
(2019)
Assessment of cardiac contractile force modulator using functionally mature human ipsc-derived cardiomyocytes [abstract 1669
O. Sirenko, E. Cromwell, C. Crittenden, Jessica Wignall, F. Wright, I. Rusyn (2013)
Assessment of beating parameters in human induced pluripotent stem cells enables quantitative in vitro screening for cardiotoxicity.Toxicology and applied pharmacology, 273 3
Gilead -Solvadi warning letter
Xi Yang, T. Papoian (2018)
Moving beyond the comprehensive in vitro proarrhythmia assay: Use of human‐induced pluripotent stem cell‐derived cardiomyocytes to assess contractile effects associated with drug‐induced structural cardiotoxicityJournal of Applied Toxicology, 38
N. Abi-Gerges, A. Pointon, Georgia Pullen, M. Morton, Karen Oldman, D. Armstrong, J. Valentin, C. Pollard (2013)
Preservation of cardiomyocytes from the adult heart.Journal of molecular and cellular cardiology, 64
Qinghui Ou, Zoë Jacobson, R. Abouleisa, Xian-Liang Tang, S. Hindi, Ashok Kumar, Kathryn Ivey, G. Giridharan, Ayman Al-Baz, K. Brittian, Benjamin Rood, Ying-Hsi Lin, S. Watson, F. Perbellini, T. McKinsey, B. Hill, Steven Jones, C. Terracciano, R. Bolli, T. Mohamed (2019)
A Physiological Biomimetic Culture System for Pig and Human Heart Slices.Circulation research
P. Sager, Jonathan Seltzer, J. Turner, Jeffrey Anderson, W. Hiatt, P. Kowey, J. Prochaska, N. Stockbridge, W. White (2014)
Rechanneling the cardiac proarrhythmia safety paradigm: a meeting report from the Cardiac Safety Research Consortium.American heart journal, 167 3
Susanne Rehnelt, D. Malan, K. Juhász, Benjamin Wolters, Leo Doerr, M. Beckler, R. Kettenhofen, H. Bohlen, T. Bruegmann, P. Sasse (2017)
Frequency-Dependent Multi-Well Cardiotoxicity Screening Enabled by Optogenetic StimulationInternational Journal of Molecular Sciences, 18
C. Regan, P. Morissette, H. Regan, J. Travis, P. Gerenser, Jianzhong Wen, K. Fitzgerald, Shaun Gruver, J. Degeorge, F. Sannajust (2016)
Assessment of the clinical cardiac drug‐drug interaction associated with the combination of hepatitis C virus nucleotide inhibitors and amiodarone in guinea pigs and rhesus monkeysHepatology, 64
Peter Dogterom, G. Zbinden, Gerd Reznik (1992)
Cardiotoxicity of vasodilators and positive inotropic/vasodilating drugs in dogs: an overview.Critical reviews in toxicology, 22 3-4
D. Back, D. Burger (2015)
Interaction between amiodarone and sofosbuvir-based treatment for hepatitis C virus infection: potential mechanisms and lessons to be learned.Gastroenterology, 149 6
Given that cardiovascular safety concerns remain the leading cause of drug attrition at the preclinical drug development stage, the National Center for Toxicological Research of the US Food and Drug Administration hosted a workshop to discuss current gaps and challenges in translating preclinical cardiovascular safety data to humans. This white paper summarizes the topics presented by speakers from academia, industry, and government intended to address the theme of improving cardiotoxicity assessment in drug development. The main conclusion is that to reduce cardiovascular safety liabilities of new therapeutic agents, there is an urgent need to integrate human-relevant platforms/approaches into drug development. Potential regulatory applications of human-derived cardiomyocytes and future directions in employing human-relevant platforms to fill the gaps and overcome barriers and challenges in preclinical cardiovascular safety assessment were discussed. This paper is intended to serve as an initial step in a public-private collaborative development program for human-relevant cardiotoxicity tools, particularly for cardiotoxicities characterized by contractile dysfunction or structural injury.
Circulation Research – Wolters Kluwer Health
Published: Oct 11, 2019
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