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V. Ramundo, L. Lamartina, R. Falcone, L. Ciotti, Cristiano Lomonaco, M. Biffoni, L. Giacomelli, M. Maranghi, C. Durante, G. Grani (2018)
Is thyroid nodule location associated with malignancy risk?Ultrasonography, 38
R. Pastorello, Ediel Valério, A. Lobo, Antonio Maia, M. Saieg (2020)
Do thyroid nodules that arise in the isthmus have a higher risk of malignancy?Cancer cytopathology
update
R. Lloyd, R. Osamura, G. Klöppel, J. Rosai (2017)
WHO classification of tumours of endocrine organs
(2020)
Estimate/2020 – cancer incidence in Brazil
Young Lee, S. Na, Hoon-Taek Chung, S. Kim, Y. Eun (2016)
Clinicopathologic characteristics and pattern of central lymph node metastasis in papillary thyroid cancer located in the isthmusThe Laryngoscope, 126
H. Fagman, M. Nilsson (2010)
Morphogenesis of the thyroid glandMolecular and Cellular Endocrinology, 323
E. Cibas, Syed Ali (2009)
The Bethesda System for Reporting Thyroid CytopathologyAmerican journal of clinical pathology, 132 5
S. Hahn, B. Han, E. Ko, J. Shin, E. Ko (2014)
Ultrasound findings of papillary thyroid carcinoma originating in the isthmus: comparison with lobe-originating papillary thyroid carcinoma.AJR. American journal of roentgenology, 203 3
G. Fadda, E. Rossi (2011)
Liquid-Based Cytology in Fine-Needle Aspiration Biopsies of the Thyroid GlandActa Cytologica, 55
F. Bray, J. Ferlay, I. Soerjomataram, R. Siegel, Lindsey Torre, A. Jemal (2018)
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countriesCA: A Cancer Journal for Clinicians, 68
S. Jasim, T. Baranski, Shalene Teefey, W. Middleton (2020)
Investigating the effect of thyroid nodule location on the risk of thyroid cancer.Thyroid : official journal of the American Thyroid Association
C. Song, D. Lee, Y. Ji, J. Jeong, Jung Park, K. Tae (2016)
Frequency and pattern of central lymph node metastasis in papillary carcinoma of the thyroid isthmusHead & Neck, 38
I. Martín-Lacave, M. Borrero, J. Utrilla, J. Fernández-Santos, M. Miguel, J. Morillo, Josep Guerrero, R. García-Marín, E. Conde (2009)
C cells evolve at the same rhythm as follicular cells when thyroidal status changes in ratsJournal of Anatomy, 214
I. Vasileiadis, G. Boutzios, M. Karalaki, E. Misiakos, T. Karatzas (2017)
Papillary thyroid carcinoma of the isthmus: Total thyroidectomy or isthmusectomy?American journal of surgery, 216 1
M. Goldfarb, Steven Rodgers, J. Lew (2012)
Appropriate surgical procedure for dominant thyroid nodules of the isthmus 1 cm or larger.Archives of surgery, 147 9
T. Zhang, Xiuzhu Qi, Jian-ping Chen, R. Shi, Shi-shuai Wen, Yu‐Long Wang, Q. Ji, Q. Shen, Yong-xue Zhu, N. Qu (2019)
The association between tumor's location and cervical lymph nodes metastasis in papillary thyroid cancer.Gland surgery, 8 5
T. Karatzas, G. Charitoudis, D. Vasileiadis, S. Kapetanakis, I. Vasileiadis (2015)
Surgical treatment for dominant malignant nodules of the isthmus of the thyroid gland: A case control study.International journal of surgery, 18
J. Ford, S. Thakar, Bradley Thuro, B. Esmaeli (2017)
Prognostic Value of the Staging System for Eyelid Tumors in the 7th Edition of the American Joint Committee on Cancer Staging Manual.Ophthalmic plastic and reconstructive surgery, 33 5
Y. Chai, Su-jin Kim, J. Choi, D. Koo, K. Lee, Y. Youn (2014)
Papillary Thyroid Carcinoma Located in the Isthmus or Upper Third is Associated with Delphian Lymph Node MetastasisWorld Journal of Surgery, 38
Introduction: Thyroid isthmus is defined as the thin band connecting thyroid tissue between both lateral thyroid lobes. Recently, a possible association between thyroid nodules located in the isthmus and malignancy was proposed. The aim of this study was to compare the frequency of The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) categories between nodules from the isthmus and nodules from both thyroid lobes. Methods: All fine needle aspiration cytology procedures performed between January 2016 and December 2019 at the Pathology Institute of Araçatuba, São Paulo, Brazil, were analyzed. For each nodule, at least 2 conventional slides were produced (1 stained by Giemsa and the other by hematoxylin and eosin). All cases were reported according to the TBSRTC. Clinical information (gender, age, and localization) and ultrasound data (size of nodules) were collected from medical requisition forms. To assess the association between the frequency of TBSRTC categories and nodule location, univariate analysis was performed using the χ<sup>2</sup> test or Fisher’s exact test, as appropriate. A p value <0.05 was considered statistically significant. Nodules located in transition between the isthmus and a right or left lobe were included in the isthmus group. Results: Considering the p value between the TBSRTC categories and thyroid nodule location, statistic association was not observed: nondiagnostic or unsatisfactory (p = 0.1442), atypia of undetermined significance or follicular lesion of undetermined significance (p = 0.3296), follicular neoplasm or suspicious for a follicular neoplasm (p = 0.0817), suspicious for malignancy (p = 0.8464), and malignant (p = 0.1082). Conclusion: In the studied population, nodules located in the isthmus were not related to any Bethesda System category.
Acta Cytologica – Karger
Published: Jan 1, 2021
Keywords: Thyroid; Cytology; Methods; Fine needle aspiration cytology
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